Rabbit Polyclonal CP2c antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TFCP2 aa 1-200.
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
WB | |
---|---|
Human | Tested |
Chicken | Predicted |
Cow | Predicted |
Xenopus laevis | Predicted |
Xenopus tropicalis | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Chicken, Cow, Xenopus laevis, Xenopus tropicalis | Dilution info - | Notes - |
Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.
LSF, SEF, TFCP2, Alpha-globin transcription factor CP2, SAA3 enhancer factor, Transcription factor LSF
Rabbit Polyclonal CP2c antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TFCP2 aa 1-200.
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
CP2c also known as LSF or TFCP2 functions as a transcription factor involved in the regulation of gene expression. CP2c has a mass of approximately 37 kDa. It is expressed in various tissues with higher levels observed in the liver brain and lymphoid tissues. This protein is critical in influencing the expression of genes through direct binding to specific DNA sequences thereby altering transcriptional activities.
CP2c serves as an important component in transcriptional regulation networks. It often functions as a part of multi-protein complexes interacting with co-activators or co-repressors to modulate target gene expression. CP2c plays significant roles in cell cycle control growth and differentiation by regulating genes involved in these biological processes.
CP2c integrates into key regulatory networks impacting several important pathways such as cell cycle and nucleotide metabolism. In the context of the cell cycle CP2c interacts with proteins such as p53 and Rb which are essential in controlling cell division and DNA repair processes. These interactions help maintain normal cellular function and prevent unchecked cell proliferation.
CP2c links to conditions like cancer and viral infections. Its regulation of genes involved in cell proliferation is important in oncogenesis where dysregulated CP2c activity may contribute to tumor progression. In viral infections CP2c modulates the host cellular environment affecting how viruses replicate within host cells. Aberrant interactions with proteins like p53 reinforce the connection between CP2c and the development of cancer emphasizing the importance of this protein as a target for therapeutic intervention.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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All lanes: Western blot - Anti-CP2c antibody (ab155238) at 1/2000 dilution
All lanes: Raji cell lysate at 30 µg
Developed using the ECL technique.
Predicted band size: 57 kDa
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