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AB251685

Anti-CPA3 antibody

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(1 Publication)

Rabbit Polyclonal CPA3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Mast cell carboxypeptidase A aa 1-200.

View Alternative Names

Mast cell carboxypeptidase A, MC-CPA, Carboxypeptidase A3, CPA3

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPA3 antibody (AB251685)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPA3 antibody (AB251685)

Paraffin-embedded human small intestine tissue stained for CPA3 using ab251685 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPA3 antibody (AB251685)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPA3 antibody (AB251685)

Paraffin-embedded human skin tissue stained for CPA3 using ab251685 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPA3 antibody (AB251685)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPA3 antibody (AB251685)

Paraffin-embedded human cervix, uterine tissue stained for CPA3 using ab251685 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPA3 antibody (AB251685)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPA3 antibody (AB251685)

Paraffin-embedded human skeletal muscle tissue stained for CPA3 using ab251685 at 1/500 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Mast cell carboxypeptidase A aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

P15088

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000.00000 - 1/2500.00000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Carboxypeptidase A3 (CPA3) also known as mast cell carboxypeptidase A is an enzyme with a molecular mass of approximately 50 kDa. It belongs to the metallo-carboxypeptidase family and acts as a proenzyme. CPA3 is primarily expressed in mast cells which predominantly reside in connective tissues such as skin respiratory tract and gastrointestinal tract. This protein contributes to the degradation of certain peptides by cleaving carboxy-terminal amino acids particularly aromatic and branched-chain amino acids.
Biological function summary

CPA3 plays an important role in the defense mechanisms of the body. It is involved in the process of mast cell degranulation releasing various mediators that participate in immune responses. CPA3 functions in combination with other enzymes including tryptase and chymase creating a complex interplay for regulating inflammation. It influences vascular permeability and recruitment of other immune cells to sites of infection or injury. Additionally CPA3 can modulate activities of other proteins by processing their precursors or inactivating them.

Pathways

CPA3 integrates into immune response pathways. It contributes significantly to the inflammatory response cascade where it acts alongside proteins like tryptase and chymase to manage the activity of inflammatory peptides. Moreover CPA3 participates in the renin-angiotensin system which affects blood pressure regulation and fluid balance interacting indirectly with angiotensin-converting enzyme (ACE) and others in this critical pathway.

CPA3 relates prominently to allergic conditions such as asthma and anaphylaxis. The enzyme's participation in the degradation of peptide substrates influences the intensity and duration of allergic responses. CPA3 activity also correlates with remodeling of airway tissues in chronic respiratory conditions. Its connection with mast cell tryptase highlights its role in the pathology of systemic mastocytosis as increased expression of CPA3 occurs in this disorder affecting clinical manifestations in patients.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Mast cell carboxypeptidase A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 9:764109 PubMed34938733

2021

Identification of the Recombinant Surface-Related Antigen as a Possible Immune Evasion Factor Against Human Splenic Fibroblasts by Targeting ITGB1.

Applications

Unspecified application

Species

Unspecified reactive species

Haitian Fu,Jiachen Lu,Xinxin Zhang,Bo Wang,Yifan Sun,Yao Lei,Feihu Shen,Kokouvi Kassegne,Eun-Taek Han,Yang Cheng
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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