Anti-CPEB1 antibody [EPR11775(2)]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) functions mechanically as a regulator of mRNA translation. Often referred to simply as CPEB1 this protein has a mass of approximately 62 kDa. CPEB1 is expressed in various tissues including the brain and ovary indicating its role in diverse physiological processes. It binds to the cytoplasmic polyadenylation element typically found at the 3' untranslated region of mRNAs controlling the length of the poly(A) tail and therefore influencing mRNA stability and translation.

Biological function summary

CPEB1 regulates cell cycle progression synaptic plasticity and gametogenesis. This protein sometimes part of larger ribonucleoprotein complexes acts by coordinating the temporal and spatial translation of target mRNAs. In neurons CPEB1 plays a significant role in the regulation of local protein synthesis impacting synaptic function and plasticity. In reproductive biology it influences oocyte maturation by modulating the translation of mRNAs important for meiotic progression.

Pathways

CPEB1 plays critical roles within pathways associated with long-term potentiation and the cell cycle. In the long-term potentiation pathway CPEB1 works alongside proteins such as eIF2α to enhance synaptic strength and memory formation. In cell cycle regulation CPEB1 affects the translational activation of cyclins thereby controlling the progression through the cell cycle phases. These pathways highlight its involvement in maintaining cellular homeostasis and response to external stimuli.

Associated diseases and disorders

CPEB1 has been implicated in neurological disorders such as Alzheimer's disease and Fragile X syndrome. In Alzheimer's disease dysregulation of CPEB1 can lead to impaired synaptic function exacerbating cognitive decline. Similarly CPEB1's interaction with FMRP links it to Fragile X syndrome where it influences synaptic plasticity and neuronal development. These associations highlight the importance of CPEB1 in brain health and cognitive functionality.