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AB198898

Anti-cPLA2 beta antibody

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(4 Publications)

Rabbit Polyclonal cPLA2 beta antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human PLA2G4B.

View Alternative Names

Cytosolic phospholipase A2 beta, cPLA2-beta, Lysophospholipase A1 group IVB, Phospholipase A2 group IVB, PLA2G4B

1 Images
Western blot - Anti-cPLA2 beta antibody (AB198898)
  • WB

Supplier Data

Western blot - Anti-cPLA2 beta antibody (AB198898)

6% SDS-PAGE.

All lanes:

Western blot - Anti-cPLA2 beta antibody (ab198898) at 1/1400 dilution

Lane 1:

Mouse stomach tissue lysate at 40 µg

Lane 2:

293T cell lysate at 40 µg

Lane 3:

Jurkat cell lysate at 40 µg

Predicted band size: 88 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human PLA2G4B. The exact immunogen used to generate this antibody is proprietary information.

P0C869

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cytosolic phospholipase A2 beta (cPLA2 beta) acts as an enzyme that catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid. Arachidonic acid serves as a precursor for the synthesis of prostaglandins and leukotrienes which are important for inflammatory responses. cPLA2 beta has a molecular weight of approximately 100 kDa. It expresses in various tissues including the brain heart and skeletal muscle showing its importance in different biological functions. Researchers often refer to cPLA2 beta as PLA2G4B as another familiar name.
Biological function summary

The function of cPLA2 beta involves producing lipid mediators playing key roles in inflammation and cell signaling. cPLA2 beta associates with Ca2+-dependent phospholipase A2 proteins forming part of a complex necessary for effective enzymatic activity and substrate targeting. cPLA2 beta influences the production of inflammatory mediators by releasing arachidonic acid from cell membranes. This molecule can then enter different signaling pathways affecting tissue responses to inflammatory stimuli.

Pathways

CPLA2 beta interacts within the arachidonic acid cascade contributing to the cyclooxygenase (COX) and lipoxygenase (LOX) pathways. Through these pathways the enzyme aids in the production of prostaglandins and leukotrienes substances that mediate inflammation and immune responses. The COX pathway connects cPLA2 beta closely to COX enzymes while the LOX pathway links it to lipoxygenase enzymes. These interactions underline its role in orchestrating complex responses in the human body during inflammatory processes.

CPLA2 beta associates with inflammatory diseases like rheumatoid arthritis and cardiovascular diseases. Elevated activity of cPLA2 beta can exacerbate inflammation leading to tissue damage in rheumatoid arthritis. Moreover its link to lipid signaling pathways connects it to atherosclerosis development contributing to cardiovascular diseases. Through these conditions cPLA2 beta interacts with key proteins such as COX-2 in arthritis and inflammatory cytokines in cardiovascular disorders making it a significant target for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling.. Isoform 3. Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines.. Isoform 5. Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids.
See full target information PLA2G4B
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in aging neuroscience 15:1194203 PubMed37744400

2023

BACE1 and SCD1 are associated with neurodegeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Ferley A Bedoya-Guzmán,Mar Pacheco-Herrero,Ivan Daniel Salomon-Cruz,Angela Maria Barrera-Sandoval,Johanna Andrea Gutierrez Vargas,Javier Gustavo Villamil-Ortiz,Carlos Andres Villegas Lanau,Julián David Arias-Londoño,Estela Area-Gomez,Gloria Patricia Cardona Gomez

International journal of molecular sciences 23: PubMed36012576

2022

Ciliary Neurotrophic Factor (CNTF) Inhibits In Vitro Cementoblast Mineralization and Induces Autophagy, in Part by STAT3/ERK Commitment.

Applications

Unspecified application

Species

Unspecified reactive species

Jiawen Yong,Sabine Gröger,Julia von Bremen,Sabine Ruf

Clinical oral investigations 25:1933-1944 PubMed32820432

2020

Leptin reduces in vitro cementoblast mineralization and survival as well as induces PGE2 release by ERK1/2 commitment.

Applications

Unspecified application

Species

Unspecified reactive species

G Ruiz-Heiland,J W Yong,J von Bremen,S Ruf

Journal of lipid research 59:730-738 PubMed29478028

2018

Diabetes adversely affects phospholipid profiles in human carotid artery endarterectomy plaques.

Applications

Unspecified application

Species

Unspecified reactive species

Mohamed A Zayed,Fong-Fu Hsu,Bruce W Patterson,Yan Yan,Uzma Naim,Malik Darwesh,Gayan De Silva,Chao Yang,Clay F Semenkovich
View all publications
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