Rabbit Polyclonal cPLA2 beta antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human PLA2G4B.
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Publications
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- Frontiers in aging neuroscience 15:11942032023BACE1 and SCD1 are associated with neurodegeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFerley A Bedoya-Guzmán,Mar Pacheco-Herrero,Ivan Daniel Salomon-Cruz,Angela Maria Barrera-Sandoval,Johanna Andrea Gutierrez Vargas,Javier Gustavo Villamil-Ortiz,Carlos Andres Villegas Lanau,Julián David Arias-Londoño,Estela Area-Gomez,Gloria Patricia Cardona GomezPubMed 37744400
- International journal of molecular sciences 23:2022Ciliary Neurotrophic Factor (CNTF) Inhibits In Vitro Cementoblast Mineralization and Induces Autophagy, in Part by STAT3/ERK Commitment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiawen Yong,Sabine Gröger,Julia von Bremen,Sabine RufPubMed 36012576
- Clinical oral investigations 25:1933-19442020Leptin reduces in vitro cementoblast mineralization and survival as well as induces PGE2 release by ERK1/2 commitment.Applications:Unspecified applicationReactive species:Unspecified reactive speciesG Ruiz-Heiland,J W Yong,J von Bremen,S RufPubMed 32820432
- Journal of lipid research 59:730-7382018Diabetes adversely affects phospholipid profiles in human carotid artery endarterectomy plaques.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMohamed A Zayed,Fong-Fu Hsu,Bruce W Patterson,Yan Yan,Uzma Naim,Malik Darwesh,Gayan De Silva,Chao Yang,Clay F SemenkovichPubMed 29478028
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human PLA2G4B. The exact immunogen used to generate this antibody is proprietary information. Database link P0C869
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/1000.00000 - 1/5000.00000 | Notes - |
Species Human | Dilution info 1/1000.00000 - 1/5000.00000 | Notes - |
Target data
Function
Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling. Isoform 3. Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines. Isoform 5. Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids.
Alternative names
Cytosolic phospholipase A2 beta, cPLA2-beta, Lysophospholipase A1 group IVB, Phospholipase A2 group IVB, PLA2G4B
Recommended products
Rabbit Polyclonal cPLA2 beta antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human PLA2G4B.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human PLA2G4B. The exact immunogen used to generate this antibody is proprietary information. Database link P0C869
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Cytosolic phospholipase A2 beta (cPLA2 beta) acts as an enzyme that catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid. Arachidonic acid serves as a precursor for the synthesis of prostaglandins and leukotrienes which are important for inflammatory responses. cPLA2 beta has a molecular weight of approximately 100 kDa. It expresses in various tissues including the brain heart and skeletal muscle showing its importance in different biological functions. Researchers often refer to cPLA2 beta as PLA2G4B as another familiar name.
- Biological function summary
The function of cPLA2 beta involves producing lipid mediators playing key roles in inflammation and cell signaling. cPLA2 beta associates with Ca2+-dependent phospholipase A2 proteins forming part of a complex necessary for effective enzymatic activity and substrate targeting. cPLA2 beta influences the production of inflammatory mediators by releasing arachidonic acid from cell membranes. This molecule can then enter different signaling pathways affecting tissue responses to inflammatory stimuli.
- Pathways
CPLA2 beta interacts within the arachidonic acid cascade contributing to the cyclooxygenase (COX) and lipoxygenase (LOX) pathways. Through these pathways the enzyme aids in the production of prostaglandins and leukotrienes substances that mediate inflammation and immune responses. The COX pathway connects cPLA2 beta closely to COX enzymes while the LOX pathway links it to lipoxygenase enzymes. These interactions underline its role in orchestrating complex responses in the human body during inflammatory processes.
- Associated diseases and disorders
CPLA2 beta associates with inflammatory diseases like rheumatoid arthritis and cardiovascular diseases. Elevated activity of cPLA2 beta can exacerbate inflammation leading to tissue damage in rheumatoid arthritis. Moreover its link to lipid signaling pathways connects it to atherosclerosis development contributing to cardiovascular diseases. Through these conditions cPLA2 beta interacts with key proteins such as COX-2 in arthritis and inflammatory cytokines in cardiovascular disorders making it a significant target for therapeutic intervention.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-cPLA2 beta antibody (ab198898)
6% SDS-PAGE.
All lanes: Western blot - Anti-cPLA2 beta antibody (ab198898) at 1/1400 dilution
Lane 1: Mouse stomach tissue lysate at 40 µg
Lane 2: 293T cell lysate at 40 µg
Lane 3: Jurkat cell lysate at 40 µg
Predicted band size: 88 kDa
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