Rabbit Polyclonal CPNE3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CPNE3 aa 200 to C-terminus.
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Publications
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- Cancer management and research 10:3057-30672018Silencing the expression of copine-III enhances the sensitivity of hepatocellular carcinoma cells to the molecular targeted agent sorafenib.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhuo Chen et. al.PubMed 30214300
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human CPNE3 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O75131
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Cow | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Cow | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Cow | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).
Alternative names
CPN3, KIAA0636, CPNE3, Copine-3, Copine III
Recommended products
Rabbit Polyclonal CPNE3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CPNE3 aa 200 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human CPNE3 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O75131
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CPNE3 also known as Copine-3 is a calcium-dependent membrane-binding protein. This protein has a molecular mass of approximately 58 kDa and belongs to the copine family. It consists of two common elements the C2 domain and the A domain known as Von Willebrand factor type A (VWA). CPNE3 expresses in tissues like brain heart and skeletal muscle. These domains enable CPNE3 to associate with cellular membranes in response to calcium signaling implying a role in intracellular signal transduction.
- Biological function summary
CPNE3 influences cellular processes such as membrane trafficking signal transduction and cytoskeletal organization. It is not currently known to be a part of any complex but it is thought to mediate interaction between various cellular components through its modular domains. Its role in signal transduction links it to processes like cell movement apoptosis and differentiation. CPNE3 potentially triggers cellular responses by interacting with other proteins and lipids within the cell environment.
- Pathways
CPNE3 actively participates in signaling related to calcium influx and integrin pathways. It is associated with the calcium signaling pathway that is significant for various cellular activities like muscle contraction and neurotransmitter release. Additionally CPNE3’s interaction within the integrin signaling pathway implicates its role in extracellular matrix adhesion and cellular assembly. Through these pathways CPNE3 interacts with proteins such as integrins and calmodulin influencing cell adhesion and motility.
- Associated diseases and disorders
CPNE3 relates closely to cancer and cardiovascular diseases. Its increased expression in some cancers suggests a connection to tumor progression and metastasis particularly in ovarian cancer and glioblastoma. CPNE3 is connected to proteins such as EGFR and Akt in the context of cancer which are key players in cell proliferation and survival pathways. In cardiovascular diseases its capability to influence muscle function relates to proteins involved in calcium homeostasis impacting conditions like hypertrophy.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-CPNE3 antibody (ab97919)
7.5% SDS PAGE
All lanes: Western blot - Anti-CPNE3 antibody (ab97919) at 1/500 dilution
Lane 1: HeLaS3 whole cell lysate at 30 µg
Lane 2: HepG2 whole cell lysate at 30 µg
Predicted band size: 60 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPNE3 antibody (ab97919)
Immunohistochemical analysis of paraffin-embedded ovarian carcinoma, using ab97919 at 1/100 dilution.
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