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AB68547

Anti-CPNE7 antibody [CPNE7-01]

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(2 Publications)

Mouse Monoclonal CPNE7 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CPNE7.

View Alternative Names

Copine-7, Copine VII, CPNE7

1 Images
Western blot - Anti-CPNE7 antibody [CPNE7-01] (AB68547)
  • WB

Supplier Data

Western blot - Anti-CPNE7 antibody [CPNE7-01] (AB68547)

All lanes:

Western blot - Anti-CPNE7 antibody [CPNE7-01] (ab68547) at 1 µg/mL

Lane 1:

HeLa cell lysate- nuclear fraction

Lane 2:

HeLa cell lysate- cytoplasmic fraction

Predicted band size: 70 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

CPNE7-01

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human CPNE7. The exact immunogen used to generate this antibody is proprietary information.

Q9UBL6

Specificity

ab68547 recognizes C terminus of human CPNE7.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.098% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CPNE7 also known as copine-7 is a protein with a molecular weight of approximately 64 kDa. It belongs to the copine family which includes calcium-dependent membrane-binding proteins. CPNE7 contains C2 domains which allow it to interact with phospholipids in a calcium-dependent manner. This protein is highly expressed in neuronal tissues like the brain but you can also find it in other tissues at lower levels. Its expression suggests a role in cellular processes that require precise regulation by calcium.
Biological function summary

CPNE7 modulates cellular mechanisms involved in signal transduction and membrane trafficking. It does not currently belong to a specific multi-protein complex but it interacts dynamically with other membrane-associated proteins due to its phospholipid-binding ability. CPNE7 plays a role in regulating neuronal growth and differentiation which are essential processes for maintaining proper brain function. Additionally its involvement in cell adhesion suggests a part in tissue repair and cellular communication.

Pathways

Calcium signaling and the phosphatidylinositol signaling pathway are two important ones involving CPNE7. This protein interacts with other calcium-binding proteins in the pathways to mediate signal transduction processes. CPNE7 regulates interactions among phospholipids and affects cellular responses to external stimuli. It modulates activity of proteins like protein kinase C which is important for many cellular functions including growth differentiation and apoptosis.

Studies link CPNE7 to neurodegenerative diseases such as Alzheimer's disease where calcium dysregulation plays an important role. Alterations in CPNE7 function can contribute to the disease progression by affecting neuronal viability and synaptic integrity. Researchers also link CPNE7 to cancer as it participates in pathways that regulate cell proliferation and migration. Proteins such as protein kinase C could be affected by CPNE7 dysregulation in these diseases highlighting its significance in disease mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
See full target information CPNE7
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 28:e18261 PubMed38526029

2024

Depletion of CPNE7 sensitizes colorectal cancer to 5-fluorouracil by downregulating ATG9B expression.

Applications

Unspecified application

Species

Unspecified reactive species

Weile Xu,Yujie Tang,Yang Yang,Changjing Wang,Chen Liu,Jianqing Zhang,Lianmei Zhao,Guiying Wang

Nature communications 13:4268 PubMed35879332

2022

Integrin α3β1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis.

Applications

Unspecified application

Species

Unspecified reactive species

Eunnyung Bae,Ping Huang,Gaёlle Müller-Greven,Dolores Hambardzumyan,Andrew Edward Sloan,Amy S Nowacki,Nicholas Marko,Cathleen R Carlin,Candece L Gladson
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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