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AB272896

Anti-CPT1B antibody

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Rabbit Polyclonal CPT1B antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human CPT1B.

View Alternative Names

KIAA1670, CPT1B, CPT1-M, Carnitine palmitoyltransferase 1B, Carnitine palmitoyltransferase I-like protein, CPT I, CPTI-M

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-CPT1B antibody (AB272896)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CPT1B antibody (AB272896)

Methanol-fixed HeLa cells stained for CPT1B (green) using ab272896 at 1/500 dilution in ICC/IF. Alpha-tubulin filaments were labeled (Red) at 1/2000.

Western blot - Anti-CPT1B antibody (AB272896)
  • WB

Unknown

Western blot - Anti-CPT1B antibody (AB272896)

All lanes:

Western blot - Anti-CPT1B antibody (ab272896) at 1/1000 dilution

All lanes:

HeLa cell lysate at 30 µg

Predicted band size: 87 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human CPT1B. The exact immunogen used to generate this antibody is proprietary information.

Q92523

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Complementary Products

Primary Antibodies

AB128568

Anti-CPT1A antibody [8F6AE9]

BOND RX™ Validated|KO Validated

Western blot - Anti-CPT1A antibody [8F6AE9] (AB128568)

  • 5
  • 5
Primary Antibodies

AB181114

Anti-CPT2 antibody [EPR13626] - C-terminal

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-CPT2 antibody [EPR13626] - C-terminal (AB181114)

  • 2
  • 1
Proteins & Peptides

AB114959

Recombinant Human CPT1B protein

SDS-PAGE - Recombinant Human CPT1B protein (AB114959)

  • 0
  • 0
Primary Antibodies

AB22759

Anti-Fatty Acid Synthase antibody

KO Validated

Western blot - Anti-Fatty Acid Synthase antibody (AB22759)

  • 5
  • 14
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Carnitine palmitoyltransferase 1B (CPT1B) also known as CPT1-M is an enzyme important for fatty acid metabolism. This protein has a molecular weight of about 88 kDa. It is expressed mainly in skeletal muscle tissue and heart. CPT1B is involved in the transport of long-chain fatty acids into the mitochondria which is necessary for beta-oxidation an important metabolic process where fatty acids are broken down to generate energy.
Biological function summary

CPT1B serves an important role in energy metabolism by enabling the conversion of fatty acids into energy within muscle cells. This protein functions as part of the carnitine shuttle complex in conjunction with carnitine-acylcarnitine translocase (CACT) and carnitine palmitoyltransferase 2 (CPT2). This system collectively facilitates the translocation of fatty acids into the mitochondria for subsequent breakdown and energy production.

Pathways

CPT1B plays a role in fatty acid oxidation and energy metabolism pathways. It helps regulate the balance of energy production by modulating the entry of fatty acids into mitochondria. In these pathways CPT1B interacts with CPT2 and CACT ensuring efficient fatty acid transport and oxidation. Through these interactions it helps maintain energy homeostasis especially in tissues with high metabolic demands like muscle and heart.

CPT1B has associations with metabolic conditions such as obesity and insulin resistance. When CPT1B function is impaired it can lead to inefficient fatty acid metabolism contributing to lipid accumulation and metabolic dysfunction. Also connections exist between CPT1B activity and symptoms of metabolic syndrome where alterations in CPT1B expression may impact energy utilization and fat storage in muscle tissue.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion.
See full target information CPT1B
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Product promise

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For full details, please see our Terms & Conditions

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