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AB185574

Anti-CPTP antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal CPTP antibody. N-terminal. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CPTP aa 1-50.

View Alternative Names

GLTPD1, CPTP, Ceramide-1-phosphate transfer protein, Glycolipid transfer protein domain-containing protein 1, GLTP domain-containing protein 1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-CPTP antibody - N-terminal (AB185574)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CPTP antibody - N-terminal (AB185574)

A431 cells stained for CPTP (green) using ab185574 at 2 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPTP antibody - N-terminal (AB185574)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPTP antibody - N-terminal (AB185574)

Immunohistochemistry of paraffin-embedded Human small intestine tissue labeling CPTP using ab185574 at 1/20.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human CPTP aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q5TA50

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CPTP also known as ceramide-1-phosphate transfer protein is a specialized protein that facilitates the transfer of ceramide-1-phosphate (C1P) between membranes. CPTP has a molecular mass of approximately 25 kDa. You can find it widely expressed in tissues such as liver lung and kidney indicating its significant functional roles across different organ systems. Its structural characteristics make it a critical facilitator in the local distribution of lipids contributing to cellular lipid homeostasis.
Biological function summary

The transfer of C1P by CPTP plays an important role in various signaling pathways and cellular processes. While it's not a component of a larger complex CPTP functions independently to mediate the intermembrane transport of its lipid substrate. This activity influences processes such as cell proliferation inflammation and apoptosis. Through its interaction with C1P CPTP significantly impacts cellular responses to stress and external stimuli serving as a vital regulator of cell fate.

Pathways

CPTP and its associated lipid transport function integrate into essential biological routes such as the sphingolipid signaling pathway and the peroxisome proliferator-activated receptor (PPAR) signaling pathway. In these pathways C1P collaborates with proteins like sphingosine kinases and cPLA2 to affect cellular responses. The transport activity of CPTP ensures the precise localization of C1P providing a fine-tuning mechanism necessary for maintaining pathway integrity and function.

Dysregulation of CPTP activity has been linked to conditions such as inflammatory diseases and metabolic disorders. Inflammatory processes might get disrupted with altered CPTP function due to its regulation of lipid mediators of inflammation. Additionally abnormal lipid signaling through proteins related to CPTP like cPLA2 may contribute to the pathogenesis of metabolic syndrome. Further understanding of CPTP's disease associations offers the potential for novel therapeutic targets to mitigate these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16 : 0 or monounsaturated C18 : 1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24 : 0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (PubMed : 28011644). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed : 29164996).
See full target information CPTP
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature 646:493-500 PubMed40836086

2025

Structural basis for the dynamic regulation of mTORC1 by amino acids.

Applications

Unspecified application

Species

Unspecified reactive species

Max L Valenstein,Maximilian Wranik,Pranav V Lalgudi,Karen Y Linde-Garelli,Yuri Choi,Raghu R Chivukula,David M Sabatini,Kacper B Rogala
View all publications
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