AB183030

Anti-CRABP2 antibody [EPR14255]

RabMAb
Recombinant
What is this?

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(1 Publication)

Rabbit Recombinant Monoclonal CRABP2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication.

View Alternative Names

Cellular retinoic acid-binding protein 2, Cellular retinoic acid-binding protein II, CRABP-II, CRABP2

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-CRABP2 antibody [EPR14255] (AB183030)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CRABP2 antibody [EPR14255] (AB183030)

Immunofluorescent analysis of HT29 cells (paraformaldehyde-fixed 4%) labeling CRABP2 with ab183030 at 1/100 dilution followed by Goat anti rabbit IgG (Alexa Fluor® 488) secondary at 1/200 dilution and counter-stained with DAPI (blue).

Supplier Data

Western blot - Anti-CRABP2 antibody [EPR14255] (AB183030)

All lanes:

Western blot - Anti-CRABP2 antibody [EPR14255] (ab183030) at 1/2000 dilution

All lanes:

HT29 cell lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Predicted band size: 16 kDa

false

Supplier Data

Western blot - Anti-CRABP2 antibody [EPR14255] (AB183030)

All lanes:

Western blot - Anti-CRABP2 antibody [EPR14255] (ab183030) at 1/10000 dilution

All lanes:

MCF7 cell lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Predicted band size: 16 kDa

false

Carrier free

Anti-CRABP2 antibody [EPR14255] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR14255

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100", "ICCIF-species-notes": "<p></p>" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cellular Retinoic Acid-Binding Protein 2 (CRABP2) mechanically facilitates cellular retinoic acid (RA) signaling by transporting RA to the nucleus. The protein is also known as CRABP II and is approximately 15 kDa in mass. You can find its expression in various tissues including skin adipose tissue and brain where it exhibits specific roles in RA signaling and cellular differentiation processes.

Biological function summary

CRABP2 participates in modulating the availability of RA which influences gene expression by binding to nuclear receptors. Although CRABP2 functions independently rather than as part of a larger protein complex it holds a significant role in gene transcription regulation. This active role in regulating RA levels impacts cellular differentiation and proliferation processes essential for tissue development and homeostasis.

Pathways

CRABP2 is an important participant in the retinoic acid signaling pathway. This pathway impacts important biological processes such as embryonic development and cell growth. CRABP2 closely interacts with the retinoic acid receptor (RAR) guiding RA to RARs and contributing to the regulation of gene expression. Moreover it is linked to the transforming growth factor-beta (TGF-beta) pathway playing a role in managing cellular apoptosis and differentiation.

Researchers associate CRABP2 with several cancers notably skin cancer due to its influence on cell proliferation. Altered expression or function of CRABP2 can also affect neurodegenerative diseases impacting pathways involving neuronal survival. CRABP2's interactions with proteins like RAR and in cancer contexts with overexpressed RA receptors highlight its relevance in modulating RA-dependent processes that can lead to pathological states.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.

See full target information CRABP2

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:4298 PubMed39905216

2025

CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Jianqiang Wu,Lixia Chen,Peijun Wen

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CRABP2 antibody [EPR14255]

Immunocytochemistry/ Immunofluorescence - Anti-CRABP2 antibody [EPR14255] (AB183030)

Western blot - Anti-CRABP2 antibody [EPR14255] (AB183030)

Western blot - Anti-CRABP2 antibody [EPR14255] (AB183030)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise