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AB176595

Anti-CRAMP1L antibody

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Rabbit Polyclonal CRAMP1L antibody. Suitable for IP and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human CRAMP1 aa 300-350.

View Alternative Names

C16orf34, CRAMP1L, HN1L, KIAA1426, CRAMP1, Protein cramped-like, Cramped chromatin regulator homolog 1, Hematological and neurological expressed 1-like protein

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Immunoprecipitation - Anti-CRAMP1L antibody (AB176595)
  • IP

Supplier Data

Immunoprecipitation - Anti-CRAMP1L antibody (AB176595)

Detection of CRAMP1L by Western Blot of Immunoprecipitate.
Anti-CRAMP1L antibody at 0.4μg/ml labeling CRAMP1L in Jurkat whole cell lysate immunoprecipitated using ab176595 at 6μg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection : Chemiluminescence with exposure time of 3 minutes.

All lanes:

Immunoprecipitation - Anti-CRAMP1L antibody (ab176595)

Predicted band size: 135 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP

applications

Immunogen

Synthetic Peptide within Human CRAMP1 aa 300-350. The exact immunogen used to generate this antibody is proprietary information.

Q96RY5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab176595 was affinity purified using an epitope specific to CRAMP1L immobilized on solid support.
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CRAMP1L also known as Cathelicidin-related antimicrobial peptide 1-like is a protein involved in immune response. It has a molecular mass of approximately 18 kDa. Researchers have identified its expression mainly in epithelial cells including those in mucosal tissues like the skin and gastrointestinal tract. CRAMP1L plays a direct role in antimicrobial defense contributing to the barrier function of epithelia by disrupting bacterial membranes.
Biological function summary

CRAMP1L acts as an antimicrobial peptide directly attacking pathogens through membrane disruption. It does not function as a part of a larger complex but contributes independently to the innate immune response. It is especially important in the first line of defense against bacterial infections playing a role in neutralizing pathogens before they can cause harm. Its activity complements the broader immune system by providing immediate response capabilities.

Pathways

CRAMP1L participates in the immune response and inflammation pathways. These pathways involve interactions with toll-like receptors and influence signaling cascades such as NF-kB a central regulator of immune response genes. CRAMP1L's action and regulation relate to other antimicrobial peptides and inflammatory cytokines modulating the body's defense mechanisms. There is interaction with related proteins like LL-37 which also forms part of the innate immune roster.

CRAMP1L has significant implications for inflammatory bowel disease and psoriasis. Inflammatory bowel disease links to its role in maintaining intestinal mucosal barrier integrity where CRAMP1L's expression may be altered. Psoriasis a condition characterized by chronic skin inflammation involves abnormal levels of CRAMP1L expression. Connections to proteins like beta-defensins which also have antimicrobial activity emphasize CRAMP1L's relevance in these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information CRAMP1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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