AB168928

Anti-CREB5 antibody

Name: Anti-CREB5 antibody (ab168928) | Abcam
Brand: Abcam Limited
SKU: AB168928
Price: 535 USD
Availability: InStock

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(10 Publications)

Mouse Polyclonal CREB5 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CREB5.

View Alternative Names

CREBPA, CREB5, Cyclic AMP-responsive element-binding protein 5, CREB-5, cAMP-responsive element-binding protein 5, cAMP-response element-binding protein A, CRE-BPa

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-CREB5 antibody (AB168928)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CREB5 antibody (AB168928)

Immunofluorescent analysis of HeLa cells labeling CREB5 with ab168928 at 10 µg/ml.

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CREB5.

Q02930

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CREB5 also known as cAMP responsive element binding protein 5 is a transcription factor important for regulating gene expression. This protein has a mass of approximately 57 kDa and belongs to the CREB family of proteins. It is found expressed in various tissues including the brain lung and kidney. CREB5 binds to the cAMP response element (CRE) sequence found in the promoters of certain genes to modulate their transcription.

Biological function summary

CREB5 plays a role in the response to cellular stress and adaptation. It participates in mediating cellular responses through transcriptional activation influenced by signals such as hormones growth factors and neurotransmitters. CREB5 forms complexes with other transcription factors and coactivators enhancing or repressing the transcription of target genes depending on the context. It influences processes such as differentiation proliferation and survival of cells.

Pathways

CREB5 is involved in the cAMP signaling pathways and MAPK/ERK pathways. These pathways regulate various cellular functions including metabolism cell cycle progression and synaptic plasticity. CREB5 interacts with proteins like CREB1 and CREB3 which together contribute to the dysregulation of these pathways when mutations or malfunctions occur.

CREB5 has been associated with neurodegenerative disorders like Alzheimer's disease and certain types of cancer such as lung cancer. Variants in the expression or function of CREB5 can markedly affect the disease process often interacting with proteins like ATF4 in Alzheimer's which is implicated in stress responses and with NF-kB in cancer involved in immune response and cell survival mechanisms. Understanding CREB5's role provides insights into therapeutic targets for these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Binds to the cAMP response element and activates transcription.

See full target information CREB5

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

PloS one 20:e0334414 PubMed41066419

2025

The role of lncRNA SNHG15 in UV-induced DNA damage repair.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Zhang,Jiahui Lin,Zixuan Fan,Sai Zhang,Meiqi Yang,Tingting Zhu,Qing Lu,Yuming Wang

Cancers 16: PubMed39409946

2024

Inorganic Polyphosphate Promotes Colorectal Cancer Growth via TRPM8 Receptor Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Valentina Arrè,Francesco Balestra,Rosanna Scialpi,Francesco Dituri,Rossella Donghia,Sergio Coletta,Dolores Stabile,Antonia Bianco,Leonardo Vincenti,Salvatore Fedele,Chen Shen,Giuseppe Pettinato,Maria Principia Scavo,Gianluigi Giannelli,Roberto Negro

Nature communications 15:4757 PubMed38834564

2024

Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Lan Ma,Chun-Yan Kong,Zhen Guo,Ming-Yu Wang,Pan Wang,Fang-Yuan Liu,Dan Yang,Zheng Yang,Qi-Zhu Tang

Cell death discovery 10:103 PubMed38418476

2024

CREB5 promotes the proliferation and self-renewal ability of glioma stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hyun-Jin Kim,Hye-Min Jeon,Don Carlo Batara,Seongsoo Lee,Suk Jun Lee,Jinlong Yin,Sang-Ik Park,Minha Park,Jong Bae Seo,Jinik Hwang,Young Joon Oh,Sung-Suk Suh,Sung-Hak Kim

BMC gastroenterology 23:353 PubMed37821801

2023

RFC2 promotes aerobic glycolysis and progression of colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Fuchen Lou,Mingbao Zhang

Communications biology 6:1026 PubMed37816820

2023

The ATF2/miR-3913-5p/CREB5 axis is involved in the cell proliferation and metastasis of colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Weiyu Dai,Linjie Hong,Wushuang Xiao,Luyu Zhang,Weihong Sha,Zhen Yu,Xuehua Liu,Side Liu,Yizhi Xiao,Ping Yang,Ying Peng,Jieming Zhang,Jianjiao Lin,Xiaosheng Wu,Weimei Tang,Zhizhao Lin,Li Xiang,Jiaying Li,Miaomiao Pei,Jide Wang

Cell cycle (Georgetown, Tex.) 21:2651-2663 PubMed36003063

2022

microRNA-206 prevents hepatocellular carcinoma growth and metastasis via down-regulating CREB5 and inhibiting the PI3K/AKT signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Chi,Zheng Gong,He Xin,Ziwen Wang,Zhaoyu Liu

Journal of experimental & clinical cancer research : CR 39:168 PubMed32843066

2020

CREB5 promotes invasiveness and metastasis in colorectal cancer by directly activating MET.

Applications

Unspecified application

Species

Unspecified reactive species

Shuyang Wang,Junfeng Qiu,Lei Liu,Cailin Su,Lu Qi,Chengmei Huang,Xiaoning Chen,Yaxin Zhang,Yaping Ye,Yanqing Ding,Li Liang,Wenting Liao

Cancer cell international 20:103 PubMed32256212

2020

Circular RNA circVAPA knockdown suppresses colorectal cancer cell growth process by regulating miR-125a/CREB5 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyu Zhang,Yingying Xu,Kenji Yamaguchi,Jinping Hu,Lianbo Zhang,Jianfeng Wang,Jifeng Tian,Wanying Chen

Cancer biology & therapy 20:524-536 PubMed30395767

2018

LncRNA SNHG5 affects cell proliferation, metastasis and migration of colorectal cancer through regulating miR-132-3p/CREB5.

Applications

Unspecified application

Species

Unspecified reactive species

Mingbao Zhang,Yue Li,Hongbo Wang,Weihua Yu,Sen Lin,Jianqiang Guo

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-CREB5 antibody

Immunocytochemistry/ Immunofluorescence - Anti-CREB5 antibody (AB168928)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (10)

Product promise