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Mouse Monoclonal CREB5 antibody. Suitable for ICC/IF, Flow Cyt, WB, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CREB5.

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Images

Flow Cytometry - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098), expandable thumbnail
  • Flow Cytometry - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098), expandable thumbnail
  • Western blot - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098), expandable thumbnail
  • Protein Array - Anti-CREB5 antibody [PCRP-CREB5-1G8] (AB277098), expandable thumbnail

Publications

Key facts

Isotype
IgG2b
Host species
Mouse
Storage buffer

Preservative: 0.05% Sodium azide
Constituents: 99.9% PBS, 0.05% BSA

Form
Liquid
Clonality
Monoclonal

Immunogen

  • Recombinant Full Length Protein corresponding to Human CREB5. Database link Q02930

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
ICC/IFFlow CytWBProtein Array
Human
Tested
Tested
Tested
Expected
Mouse
Predicted
Predicted
Predicted
Predicted
Rat
Predicted
Predicted
Predicted
Predicted
Recombinant full length protein - Human
Not recommended
Not recommended
Not recommended
Tested

Tested
Tested

Species
Human
Dilution info
1-2 µg/mL
Notes

-

Predicted
Predicted

Species
Mouse, Rat
Dilution info
-
Notes

-

Not recommended
Not recommended

Species
Recombinant full length protein - Human
Dilution info
-
Notes

-

Tested
Tested

Species
Human
Dilution info
1-2 µg for 106 Cells
Notes

-

Predicted
Predicted

Species
Mouse, Rat
Dilution info
-
Notes

-

Not recommended
Not recommended

Species
Recombinant full length protein - Human
Dilution info
-
Notes

-

Tested
Tested

Species
Human
Dilution info
1-2 µg/mL
Notes

-

Predicted
Predicted

Species
Mouse, Rat
Dilution info
-
Notes

-

Not recommended
Not recommended

Species
Recombinant full length protein - Human
Dilution info
-
Notes

-

Tested
Tested

Species
Recombinant full length protein - Human
Dilution info
-
Notes

-

Expected
Expected

Species
Human
Dilution info
Use at an assay dependent concentration.
Notes

-

Predicted
Predicted

Species
Mouse, Rat
Dilution info
-
Notes

-

Target data

Function

Binds to the cAMP response element and activates transcription.

Alternative names

CREBPA, CREB5, Cyclic AMP-responsive element-binding protein 5, CREB-5, cAMP-responsive element-binding protein 5, cAMP-response element-binding protein A, CRE-BPa

Recommended products

Mouse Monoclonal CREB5 antibody. Suitable for ICC/IF, Flow Cyt, WB, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CREB5.

Key facts

Isotype
IgG2b
Form
Liquid
Clonality
Monoclonal
Immunogen
  • Recombinant Full Length Protein corresponding to Human CREB5. Database link Q02930
Clone number
PCRP-CREB5-1G8
Purification technique
Affinity purification Protein A/G
Light chain type
kappa
Concentration
Loading...
Purification notes

Purified from bioreactor concentrate

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

CREB5 also known as cAMP responsive element binding protein 5 is a transcription factor important for regulating gene expression. This protein has a mass of approximately 57 kDa and belongs to the CREB family of proteins. It is found expressed in various tissues including the brain lung and kidney. CREB5 binds to the cAMP response element (CRE) sequence found in the promoters of certain genes to modulate their transcription.

Biological function summary

CREB5 plays a role in the response to cellular stress and adaptation. It participates in mediating cellular responses through transcriptional activation influenced by signals such as hormones growth factors and neurotransmitters. CREB5 forms complexes with other transcription factors and coactivators enhancing or repressing the transcription of target genes depending on the context. It influences processes such as differentiation proliferation and survival of cells.

Pathways

CREB5 is involved in the cAMP signaling pathways and MAPK/ERK pathways. These pathways regulate various cellular functions including metabolism cell cycle progression and synaptic plasticity. CREB5 interacts with proteins like CREB1 and CREB3 which together contribute to the dysregulation of these pathways when mutations or malfunctions occur.

Associated diseases and disorders

CREB5 has been associated with neurodegenerative disorders like Alzheimer's disease and certain types of cancer such as lung cancer. Variants in the expression or function of CREB5 can markedly affect the disease process often interacting with proteins like ATF4 in Alzheimer's which is implicated in stress responses and with NF-kB in cancer involved in immune response and cell survival mechanisms. Understanding CREB5's role provides insights into therapeutic targets for these conditions.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

5 product images

  • Flow Cytometry - Anti-CREB5 antibody [PCRP-CREB5-1G8] (ab277098), expandable thumbnail

    Flow Cytometry - Anti-CREB5 antibody [PCRP-CREB5-1G8] (ab277098)

    Flow cytometry analysis of PFA-fixed HeLa (human epithelial cell line from cervix adenocarcinoma) cells labeling CREB5 using ab277098 at 2 μg / 106 cells followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).

  • Immunocytochemistry/ Immunofluorescence - Anti-CREB5 antibody [PCRP-CREB5-1G8] (ab277098), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-CREB5 antibody [PCRP-CREB5-1G8] (ab277098)

    Immunofluorescence analysis of PFA-fixed K562 (human chronic myelogenous leukemia cell line from bone marrow) cells labeling CREB5 with ab277098 at 2 μg/ml, followed by goat anti-mouse IgG-CF488 (green); phalloidin counterstain (red).

  • Flow Cytometry - Anti-CREB5 antibody [PCRP-CREB5-1G8] (ab277098), expandable thumbnail

    Flow Cytometry - Anti-CREB5 antibody [PCRP-CREB5-1G8] (ab277098)

    Flow cytometry analysis of PFA-fixed K562 (human chronic myelogenous leukemia cell line from bone marrow) cells labeling CREB5 using ab277098 at 2 μg / 106 cells followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).

  • Western blot - Anti-CREB5 antibody [PCRP-CREB5-1G8] (ab277098), expandable thumbnail

    Western blot - Anti-CREB5 antibody [PCRP-CREB5-1G8] (ab277098)

    All lanes: Western blot - Anti-CREB5 antibody [PCRP-CREB5-1G8] (ab277098) at 2 µg/mL

    All lanes: HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate

    Predicted band size: 56 kDa

  • Protein Array - Anti-CREB5 antibody [PCRP-CREB5-1G8] (ab277098), expandable thumbnail

    Protein Array - Anti-CREB5 antibody [PCRP-CREB5-1G8] (ab277098)

    Analysis of Protein Array containing more than 19,000 full-length human proteins using ab277098.

    Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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