AB233282

Anti-CREG1/CREG antibody

Name: Anti-CREG1/CREG antibody (ab233282) | Abcam
Brand: Abcam Limited
SKU: AB233282
Price: 510 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal CREG1/CREG antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Creg1 aa 50 to C-terminus.

View Alternative Names

Creg, Creg1, Protein CREG1, Cellular repressor of E1A-stimulated genes 1

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CREG1/CREG antibody (AB233282)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CREG1/CREG antibody (AB233282)

Formalin-fixed, paraffin-embedded mouse kidney tissue stained for CREG1/CREG using ab233282 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CREG1/CREG antibody (AB233282)

Formalin-fixed, paraffin-embedded mouse stomach tissue stained for CREG1/CREG using ab233282 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-CREG1/CREG antibody (AB233282)

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Western blot - Anti-CREG1/CREG antibody (ab233282) at 2 µg/mL

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Mouse lung tissue lysate

Predicted band size: 24 kDa

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Supplier Data

Western blot - Anti-CREG1/CREG antibody (AB233282)

All lanes:

Western blot - Anti-CREG1/CREG antibody (ab233282) at 1 µg

All lanes:

Mouse ear tissue lysate

Predicted band size: 24 kDa

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Supplier Data

Western blot - Anti-CREG1/CREG antibody (AB233282)

All lanes:

Western blot - Anti-CREG1/CREG antibody (ab233282) at 2 µg/mL

All lanes:

Recombinant mouse CREG1/CREG protein

Predicted band size: 24 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Mouse Creg1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O88668

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CREG1 also known as CREG is a glycoprotein that interacts with transcription machinery to regulate cellular growth and morphology. The protein has a molecular mass around 25 kDa. It is expressed in various tissues with the highest expression noted in reproductive organs and the heart. CREG1 acts as a transcriptional regulator by binding to DNA elements and specific proteins such as the retinoblastoma protein (pRb). This binding contributes to its role in modulating gene expression related to cell division and differentiation.

Biological function summary

CREG1 influences cell proliferation and differentiation processes. It forms part of a complex network involving transcription factors and other proteins that govern these cellular functions. Through its interaction with pRb CREG1 can repress certain gene activities while activating others allowing it to maintain a balance between cellular growth and maturation. This balance is essential for normal development and tissue maintenance.

Pathways

CREG1 has a significant role in TGF-beta and E2F-dependent signaling. These pathways are key in cell cycle regulation apoptosis and stem cell biology. Through the E2F pathway CREG1 influences the transcriptional regulation and aids in controlling cell division. CREG1's interaction with pRb and E2F exemplifies how it modulates the progression of the cell cycle playing a part in pathways that determine cell identity and quiescence.

Irregular CREG1 activity links to cancer and cardiac disorders. Specifically abnormal expression levels can lead to cancerous growth through dysregulated cell cycle control partly mediated by its relationship with pRb. In cardiac disorders alterations in CREG1 expression are associated with heart disease as it is involved in cardiac cell homeostasis. These connections highlight the importance of CREG1 in maintaining normal cellular functions in vital organs.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R (By similarity).

See full target information Creg1

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

PloS one 20:e0328485 PubMed40674409

2025

Cellular repressor of E1A-stimulated genes 1 enhances skeletal muscle performance through the stimulation of muscle differentiation and Akt-mTOR signaling pathway activation.

Applications

Unspecified application

Species

Unspecified reactive species

Ayumi Goto,Michihiro Hashimoto,Sho Yokogawa,Yuzu Naruse,Hitoshi Yamashita

Frontiers in bioengineering and biotechnology 8:612091 PubMed33415100

2020

Proteomic Reveals Reasons for Acquired Drug Resistance in Lung Cancer Derived Brain Metastasis Based on a Newly Established Multi-Organ Microfluidic Chip Model.

Applications

Unspecified application

Species

Unspecified reactive species

Mingxin Xu,Yingyan Wang,Wenzhe Duan,Shengkai Xia,Song Wei,Wenwen Liu,Qi Wang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CREG1/CREG antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CREG1/CREG antibody (AB233282)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CREG1/CREG antibody (AB233282)

Western blot - Anti-CREG1/CREG antibody (AB233282)

Western blot - Anti-CREG1/CREG antibody (AB233282)

Western blot - Anti-CREG1/CREG antibody (AB233282)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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