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AB272542

Anti-CRIM1 antibody

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(2 Publications)

Rabbit Polyclonal CRIM1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CRIM1 aa 100-250.

View Alternative Names

S52, UNQ1886/PRO4330, CRIM1, Cysteine-rich motor neuron 1 protein, CRIM-1, Cysteine-rich repeat-containing protein S52

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRIM1 antibody (AB272542)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRIM1 antibody (AB272542)

Paraffin-embedded formalin-fixed human placenta tissue stained for CRIM1 using ab272542 at 1/50 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRIM1 antibody (AB272542)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRIM1 antibody (AB272542)

Paraffin-embedded formalin-fixed human liver tissue stained for CRIM1 using ab272542 at 1/50 dilution in immunohistochemical analysis. Shows no expression as expected.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CRIM1 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q9NZV1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CRIM1 also known as cysteine-rich motor neuron 1 protein has a molecular mass of around 110 kDa. As a transmembrane protein it localizes mainly to the endoplasmic reticulum. Researchers have detected its expression in various tissues including the retina kidneys brain and spinal cord. It contains a distinctive cysteine-rich motif and plays roles in cellular adhesion and growth factor regulation.
Biological function summary

The function of CRIM1 extends to the modulation of growth factor activity particularly by interacting with bone morphogenetic proteins (BMPs). This interaction suggests its potential involvement in developmental processes. Studies have indicated that CRIM1 might participate in forming protein complexes related to cell surface receptors influencing cell signaling pathways that govern growth and differentiation.

Pathways

CRIM1's involvement in BMP signaling and angiogenesis highlights its significance within these biological pathways. BMPs which are growth factors play a part in bone and cartilage development therefore CRIM1's regulatory action can affect these processes. Additionally CRIM1 interacts with proteins like noggin in the BMP pathway to modulate cellular responses to extracellular signals contributing to developmental and morphogenic outcomes.

CRIM1 links to congenital abnormalities and ocular disorders. Its known interaction with BMPs associates it with conditions like kidney dysplasia where the disruption of normal signaling can lead to organ malformations. In the context of eye development CRIM1's interaction with BMPs and noggin is important for retinal and lens development. Understanding CRIM1's role in these pathways could offer insights into therapeutic targets for congenital and degenerative diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.
See full target information CRIM1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:113438 PubMed41054506

2025

SARS-CoV-2 infection drives local inflammation of the intestinal epithelium in immunocompromised patients with cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Emil Lou,Christine Luo,Katherine Ladner,Allison Makovec,Phillip Wong,Jeremy Chacon,Eamon Toye,Ella Boytim,Emily Gammon Hawkins,Anthony Patregnani,Emily John,Sanyukta Padmanabhan,Akshat Sarkari,Alison Wong,Julia Stuart,Andrew C Nelson,Brian Betts,Eliseo Eugenin,Justin Hwang

Cancer cell international 22:42 PubMed35090460

2022

miR-199b-3p contributes to acquired resistance to cetuximab in colorectal cancer by targeting CRIM1 via Wnt/β-catenin signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Hu Han,Yan Li,Wan Qin,Lu Wang,Han Yin,Beibei Su,Xianglin Yuan
View all publications
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Product promise

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