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AB105951

Anti-CRISP3 antibody

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(3 Publications)

Rabbit Polyclonal CRISP3 antibody. Suitable for ELISA, WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Cysteine-rich secretory protein 3.

View Alternative Names

Cysteine-rich secretory protein 3, CRISP-3, Specific granule protein of 28 kDa, SGP28, CRISP3

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ELISA, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human Cysteine-rich secretory protein 3. The exact immunogen used to generate this antibody is proprietary information.

P54108

Specificity

ab105951 recognizes both the N-glycosylated and non-glycosylated form of the mature protein.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
0.2 µm filtered antibody solution
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CRISP3 also known as Cysteine-Rich Secretory Protein 3 is a protein key in various physiological processes. It typically weighs about 28 kDa. Found in a range of tissues but most prominently in the salivary glands pancreas and prostate. Researchers also detect CRISP3 in neutrophils. Its secretion to the extracellular environment after synthesis helps facilitate its functional roles. Scientists use ELISA assays to quantify its expression.
Biological function summary

CRISP3 participates in host defense mechanisms and inflammation. It is a part of antimicrobial complexes that safeguard the body against microbial invasion. This protein can bind to other molecules and disrupt microbial membranes. It is believed to be involved in the innate immune response. CRISP3 also appears in granules of neutrophils where it functions during pathogen encounters.

Pathways

CRISP3 interacts in immune response pathways that help buffer the body against pathogenic challenges. It aligns with the immune system's defense activities and might impact the signaling and regulatory pathways of inflammation. CRISP3's interactions with other proteins like defensins enhance its role in these immune pathways.

CRISP3 shows potential involvement in prostate cancer and Sjögren's syndrome. Its overexpression associates with prostate cancer progression and alterations in its levels might affect cancer-related proteins like PSA (prostate-specific antigen). In the context of Sjögren's syndrome CRISP3's expression changes may link to saliva secretion dysregulation impacting mucosal defense and inflammatory proteins involved in the disorder.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Cysteine-rich secretory protein 3
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Animals : an open access journal from MDPI 14: PubMed38612267

2024

Detection of Protein Biomarkers Relevant to Sperm Characteristics and Fertility in Semen in Three Wild Felidae: The Flat-Headed Cat (), Fishing Cat (), and Asiatic Golden Cat ().

Applications

Unspecified application

Species

Unspecified reactive species

Manita Wittayarat,Supalak Kiatsomboon,Navapol Kupthammasan,Wanlaya Tipkantha,Surasak Yimprasert,Ampika Thongphakdee,Saritvich Panyaboriban

Theriogenology 172:106-115 PubMed34153566

2021

CRISP protein expression in semen of the endangered Malayan tapir (Tapirus indicus).

Applications

Unspecified application

Species

Unspecified reactive species

Manita Wittayarat,Budhan S Pukazhenthi,Wanlaya Tipkantha,Mongkol Techakumphu,Sayamon Srisuwatanasagul,Saritvich Panyaboriban

Modern pathology : an official journal of the Unit 26:733-42 PubMed23196798

2012

Cysteine-rich secretory protein 3 overexpression is linked to a subset of PTEN-deleted ERG fusion-positive prostate cancers with early biochemical recurrence.

Applications

IHC-P

Species

Human

Katharina Grupp,Sebastian Kohl,Hüseyin Sirma,Ronald Simon,Stefan Steurer,Andreas Becker,Meike Adam,Jakob Izbicki,Guido Sauter,Sarah Minner,Thorsten Schlomm,Maria Christina Tsourlakis
View all publications
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Product promise

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