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AB224136

Anti-CRISPLD2 antibody

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(1 Publication)

Rabbit Polyclonal CRISPLD2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CRISPLD2 aa 150-350.

View Alternative Names

CRISP11, LCRISP2, UNQ2914/PRO1156/PRO9783, CRISPLD2, Cysteine-rich secretory protein LCCL domain-containing 2, Cysteine-rich secretory protein 11, LCCL domain-containing cysteine-rich secretory protein 2, CRISP-11

2 Images
Western blot - Anti-CRISPLD2 antibody (AB224136)
  • WB

Supplier Data

Western blot - Anti-CRISPLD2 antibody (AB224136)

All lanes:

Western blot - Anti-CRISPLD2 antibody (ab224136) at 1/100 dilution

All lanes:

BEWO cell lysate

Predicted band size: 55 kDa

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRISPLD2 antibody (AB224136)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRISPLD2 antibody (AB224136)

Paraffin-embedded human duodenum tissue stained for CRISPLD2 using ab224136 at 1/200 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CRISPLD2 aa 150-350. The exact immunogen used to generate this antibody is proprietary information.

Q9H0B8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CRISPLD2 also known as cysteine-rich secretory protein LCCL domain containing 2 carries a molecular weight of approximately 105 kDa. This protein shows expression in various tissues with notable presence in the liver and lungs. CRISPLD2 contains LCCL domains that contribute to its structure and function. Mechanically this protein functions in cellular processes related to the inflammatory response.
Biological function summary

CRISPLD2 plays a significant role in modulating inflammation. It not only participates in the regulatory circuits that control pro-inflammatory cytokines but also interacts closely with the immune system to maintain homeostasis. Although CRISPLD2 does not distinctly form part of a multi-protein complex its interactions suggest significant cross-talk within the immune signaling environment.

Pathways

CRISPLD2 takes part in the regulation of inflammatory pathways chiefly involving the cytokine signaling pathway. This participation involves interactions with molecules such as IL-6 and TNF-alpha which are key players in immune response. CRISPLD2's influence in these pathways highlights its regulatory role reducing excessive inflammatory signaling.

CRISPLD2 exhibits relevance to conditions related to inflammation including rheumatoid arthritis and systemic lupus erythematosus. These diseases involve dysregulation of inflammatory cytokines where CRISPLD2 can potentially modulate the pathological processes. Its interaction with IL-6 in these disorders highlights its contribution in controlling inflammation-mediated damage.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Promotes matrix assembly.
See full target information CRISPLD2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Proceedings of the National Academy of Sciences of the United States of America 118: PubMed33431668

2021

ATRX and RECQ5 define distinct homologous recombination subpathways.

Applications

Unspecified application

Species

Unspecified reactive species

Amira Elbakry,Szilvia Juhász,Ki Choi Chan,Markus Löbrich
View all publications
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Product promise

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