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AB96366

Anti-CRLF1 antibody

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(1 Publication)

Rabbit Polyclonal CRLF1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CRLF1 aa 100-400.

View Alternative Names

UNQ288/PRO327, CRLF1, Cytokine receptor-like factor 1, Cytokine-like factor 1, ZcytoR5, CLF-1

1 Images
Western blot - Anti-CRLF1 antibody (AB96366)
  • WB

Unknown

Western blot - Anti-CRLF1 antibody (AB96366)

10% SDS PAGE

All lanes:

Western blot - Anti-CRLF1 antibody (ab96366) at 1/3000 dilution

All lanes:

Hep G2 cell lysate at 30 µg

Predicted band size: 46 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human CRLF1 aa 100-400. The exact immunogen used to generate this antibody is proprietary information.

O75462

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CRLF1 also known as cytokine receptor-like factor 1 is a secreted protein with a molecular mass around 50 kDa. CRLF1 mainly expresses in the central nervous system and various other tissues including muscle and liver. It plays a role in immune function and neurodevelopment by forming part of a receptor complex. This protein assists in transmitting signals across cell membranes which influence growth differentiation and survival of certain cell types.
Biological function summary

Through forming a functional receptor complex with the cytokine cardiotrophin-like cytokine factor 1 (CLCF1) CRLF1 participates in cytokine signaling. The CRLF1-CLCF1 complex binds to a receptor composed of ciliary neurotrophic factor receptor (CNTFR) and leukemia inhibitory factor receptor (LIFR) activating intracellular pathways. This mechanism affects neuroprotective neurotrophic and immune-modulatory processes by promoting neuron survival and modulating immune responses.

Pathways

Its involvement in the JAK-STAT signaling pathway highlights CRLF1's role in modulating gene expression. The interactions with CRLF1 and LIFR are critical within this pathway influencing STAT3 phosphorylation and eventual transcriptional regulation. Though mainly implicated in the JAK-STAT pathway CRLF1 also overlaps with neurotrophic signaling processes working alongside proteins like CNTFR to mediate neural repair and precision immune regulation.

CRLF1 mutations are linked to several conditions including Cold-induced sweating syndrome and Crisponi syndrome—both related to dysregulation in neural and thermogenic processes. These syndromes often involve the CRLF1-associated pathway's failures to properly signal often resulting in issues consistent with complex disorders. Linked to LIFR through these pathologies CRLF1's malfunction significantly contributes to disrupted signaling networks emphasizing its association with specific developmental and immune malfunctions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system.
See full target information CRLF1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in neurology 8:278 PubMed28659861

2017

The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat.

Applications

Unspecified application

Species

Unspecified reactive species

Gábor Nagy-Grócz,Klaudia F Laborc,Gábor Veres,Attila Bajtai,Zsuzsanna Bohár,Dénes Zádori,Annamária Fejes-Szabó,Eleonóra Spekker,László Vécsei,Árpád Párdutz
View all publications
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