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AB236378

Anti-CRLF3 antibody [OTI2H3]

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Mouse Monoclonal CRLF3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CRLF3.

View Alternative Names

CREME9, CRLM9, CYTOR4, P48, CRLF3, Cytokine receptor-like factor 3, Cytokine receptor-like molecule 9, Cytokine receptor-related protein 4, Type I cytokine receptor-like factor p48, CREME-9

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRLF3 antibody [OTI2H3] (AB236378)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRLF3 antibody [OTI2H3] (AB236378)

Paraffin-embedded human spleen tissue stained for CRLF3 with ab236378 at a 1/500 dilution in immunohistochemical analysis.

Western blot - Anti-CRLF3 antibody [OTI2H3] (AB236378)
  • WB

Supplier Data

Western blot - Anti-CRLF3 antibody [OTI2H3] (AB236378)

All lanes:

Western blot - Anti-CRLF3 antibody [OTI2H3] (ab236378) at 1/500 dilution

All lanes:

NCI-H460 (Human lung cancer cell line) cell extracts at 35 µg

Predicted band size: 50 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI2H3

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CRLF3.

Q8IUI8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "<p>Heat-induced epitope retrieval by 1 mM EDTA in 10 mM Tris buffer (pH 8.5) at 120°C for 3 minutes.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Purification notes
Purified from cell culture supernatant.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CRLF3 also known as Cytokine Receptor-Like Factor 3 is a protein that acts within the cytokine receptor family. This target is involved in transmitting signals through the cell membrane. CRLF3 has a mass of approximately 50 kDa. Expression of CRLF3 occurs in a variety of tissues indicating its widespread role in cellular communication. The receptor plays a role in cytokine signaling which influences immune responses and cellular growth processes.
Biological function summary

CRLF3 contributes significantly to immune system function and neurodevelopment. It participates in forming receptor complexes necessary for signal transduction impacting various physiological processes. Studies have shown that CRLF3 participates in neuroimmune pathways linking neural and immune system activities. Researchers often explore its mechanism alongside related receptors such as those in the interleukin receptor family to fully understand its broad biological impact.

Pathways

Cytokine signaling pathways prominently involve CRLF3. Particularly it is part of the JAK-STAT signaling pathway which is important for mediating responses to various cytokines and growth factors. CRLF3 interacts with other signaling proteins including JAK kinases and STAT transcription factors to relay signals from external stimuli to the cell's interior influencing gene expression and affecting cellular responses.

Scientists have recognized connections between CRLF3 and neurological disorders. Research indicates that altered CRLF3 function may contribute to diseases such as multiple sclerosis and epilepsy. Furthermore its interaction with proteins relevant to immune response and neural signaling suggests potential roles in these conditions. Understanding CRLF3's involvement in these disorders could offer valuable insights into possible therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in the negative regulation of cell cycle progression.
See full target information CRLF3
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