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Rabbit Polyclonal CRLR antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CALCRL.


Images

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human CALCRL. The exact immunogen used to generate this antibody is proprietary information. Database link Q16602
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested
Mouse
Predicted
Rat
Predicted
Bat
Predicted
Common marmoset
Predicted
Cow
Predicted
Dog
Predicted
Elephant
Predicted
Goat
Predicted
Gorilla
Predicted
Guinea pig
Predicted
Hamster
Predicted
Horse
Predicted
Monkey
Predicted
Opossum
Predicted
Orangutan
Predicted
Pig
Predicted
Pufferfish
Predicted
Rabbit
Predicted
Xenopus laevis
Predicted
Zebrafish
Predicted

Tested
Tested

Species

Human

Dilution info

34 µg/mL

Notes

Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.

Predicted
Predicted

Species

Mouse, Rat, Rabbit, Goat, Horse, Guinea pig, Cow, Dog, Pig, Xenopus laevis, Pufferfish, Monkey, Zebrafish, Opossum, Common marmoset, Orangutan, Bat, Elephant, Hamster, Gorilla

Dilution info

-

Notes

-

Target data

Function

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2 (PubMed:22102369, PubMed:30115739). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:22102369, PubMed:30115739).

Alternative names

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Rabbit Polyclonal CRLR antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CALCRL.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human CALCRL. The exact immunogen used to generate this antibody is proprietary information. Database link Q16602
Purification technique

Affinity purification Immunogen

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except CALCR (56%).

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological function summary

CRLR operates as part of a receptor complex with RAMPs that determines its ligand specificity; this complex enables it to bind peptides such as adrenomedullin and calcitonin gene-related peptide (CGRP). When combined with different RAMPs CRLR can switch its ligand affinity and function as adrenomedullin or CGRP receptors therefore influencing vascular tone pain transmission and metabolic regulation. Research demonstrates that CRLR and its associated complexes contribute to processes like vasodilation angiogenesis and neurogenic inflammation emphasizing its role in maintaining homeostasis.

Activity summary

The Calcitonin Receptor-Like Receptor (CRLR) also known as the calcitonin receptor-like receptor functions as a G-protein-coupled receptor involved in the regulation of various physiological processes. CRLR has a molecular mass of approximately 55 kDa. This receptor is broadly expressed in numerous tissues including the cardiovascular system the central nervous system and peripheral tissues. As a receptor CRLR plays a central role in signal transduction by binding to specific peptide ligands mainly through interaction with receptor activity-modifying proteins (RAMPs) which are essential for its functional specificity.

Pathways

CRLR actively participates in critical biological pathways particularly the signaling pathways of CGRP and adrenomedullin which are significant in cardiovascular and nervous system functions. Within these pathways CRLR modulates the activity of secondary messengers such as cyclic AMP (cAMP) upon ligand binding therefore initiating further downstream effects in target cells. Related proteins including RAMPs and components of cAMP signaling work in conjunction with CRLR to ensure precise cellular responses to ligand stimulation linking it to broader physiological processes like stress response and blood pressure regulation.

Associated diseases and disorders

CRLR stands associated with conditions such as migraines and heart failure. The ability of CRLR to bind CGRP makes it a target for migraine therapies as CGRP plays a pivotal role in migraine pathophysiology. Additionally CRLR through its regulation of adrenomedullin becomes linked to heart failure given adrenomedullin's effects on vasodilation and cardiac function. In these pathological conditions CRLR often interacts with RAMPs influencing the severity and progression of the disease capturing interest for therapeutic interventions.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRLR antibody - Cytoplasmic domain (ab140761), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRLR antibody - Cytoplasmic domain (ab140761)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon (submucosal plexus and submucosal vessel) tissue labelling CRLR with ab140761 at 34 μg/ml.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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