Rabbit Polyclonal CSN4 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human COPS4 aa 350 to C-terminus.
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Publications
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- Cell cycle (Georgetown, Tex.) 18:1135-11532019Inhibition of neddylation induces mitotic defects and alters MKLP1 accumulation at the midbody during cytokinesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDudley Chung et. al.PubMed 31057046
- Molecular endocrinology (Baltimore, Md.) 28:834-452014COP9 subunits 4 and 5 target soluble guanylyl cyclase α1 and p53 in prostate cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMeenakshi Bhansali et. al.PubMed 24725084
- Molecular and cellular biology 34:1066-762014Dynamic regulation of the COP9 signalosome in response to DNA damage.
- The Journal of biological chemistry 281:17457-652006Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWonkyung Oh et. al.PubMed 16624822
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7 - 8
Preservative: 0.1% Sodium azide
Constituents: 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human COPS4 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BT78
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Tested |
| Rat | Predicted |
| Chicken | Predicted |
| Chimpanzee | Predicted |
| Cow | Predicted |
| Dog | Predicted |
| Guinea pig | Predicted |
| Horse | Predicted |
| Orangutan | Predicted |
| Pig | Predicted |
| Rabbit | Predicted |
| Rhesus monkey | Predicted |
| Turkey | Predicted |
| Zebrafish | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/2000.00000 - 1/10000.00000 | Notes - |
Species Human | Dilution info 1/2000.00000 - 1/10000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Rabbit, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Zebrafish, Rhesus monkey, Orangutan, Horse, Chimpanzee | Dilution info - | Notes - |
Associated Products
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Target data
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Alternative names
CSN4, COPS4, COP9 signalosome complex subunit 4, SGN4, Signalosome subunit 4, JAB1-containing signalosome subunit 4
Recommended products
Rabbit Polyclonal CSN4 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human COPS4 aa 350 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7 - 8
Preservative: 0.1% Sodium azide
Constituents: 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human COPS4 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BT78
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
Purified using the peptide immobilized on solid support.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
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Terms & Conditions.
1 product image
Western blot - Anti-CSN4 antibody (ab12322)
All lanes: Western blot - Anti-CSN4 antibody (ab12322) at 0.1 µg/mL
Lane 1: HeLa whole cell lysate at 50 µg
Lane 2: HEK293T whole cell lysate at 50 µg
Lane 3: Jurkat whole cell lysate at 50 µg
Lane 4: TCMK-1 whole cell lysate at 50 µg
Lane 5: NIH/3T3 whole cell lysate at 50 µg
Predicted band size: 46 kDa
Exposure time: 3min
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