Rabbit Recombinant Monoclonal CSN7A antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Images
![Western blot - Anti-CSN7A antibody [EPR6463] (AB124705), expandable thumbnail](https://content.abcam.com/products/images/csn7a-antibody-epr6463-ab124705--western-blot-img101543.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-CSN7A antibody [EPR6463] (AB124705)")
![OI-RD Scanning - Anti-CSN7A antibody [EPR6463] (AB124705), expandable thumbnail](https://content.abcam.com/products/images/csn7a-antibody-epr6463-ab124705--oi-rd-scanning-img86463.jpg/_jcr_content/renditions/webp-475.webp "OI-RD Scanning - Anti-CSN7A antibody [EPR6463] (AB124705)")
Publications
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- Experimental and therapeutic medicine 22:12022021lncRNA LOC339524 inhibits the proliferation of bladder cancer cells by targeting the miR-875-5p/COPS7A signaling axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXuan He,He Xiao,Rui Yang,Hang Chen,Bin WangPubMed 34584547
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| IP | Flow Cyt | WB | IHC-P | ICC/IF | |
|---|---|---|---|---|---|
| Human | Not recommended | Not recommended | Tested | Not recommended | Not recommended |
| Rat | Not recommended | Not recommended | Predicted | Not recommended | Not recommended |
IP
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Rat | Dilution info - | Notes - |
Flow Cyt
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Rat | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000 - 1/10000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
IHC-P
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Rat | Dilution info - | Notes - |
ICC/IF
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Rat | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Alternative names
CSN7A, DERP10, COPS7A, COP9 signalosome complex subunit 7a, SGN7a, Signalosome subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a
Recommended products
Rabbit Recombinant Monoclonal CSN7A antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- EPR6463
- Purification technique
- Affinity purification Protein A
- Dissociation constant
- 1.35 x 10-10 M
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
Species reactivity
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please contact us for more information.
Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
![Western blot - Anti-CSN7A antibody [EPR6463] (ab124705), expandable thumbnail](https://content.abcam.com/products/images/csn7a-antibody-epr6463-ab124705--western-blot-img101543.jpg "Western blot - Anti-CSN7A antibody [EPR6463] (ab124705)")
Western blot - Anti-CSN7A antibody [EPR6463] (ab124705)
Standard HRP labelled goat anti-rabbit at 1:2000.
All lanes: Western blot - Anti-CSN7A antibody [EPR6463] (ab124705) at 1/1000 dilution
Lane 1: HeLa cell lysate at 10 µg
Lane 2: JAR cell lysate at 10 µg
Lane 3: Human fetal muscle cell lysate at 10 µg
Lane 4: Human brain cell lysate at 10 µg
Lane 5: Human heart cell lysate at 10 µg
Lane 6: Human kidney cell lysate at 10 µg
Predicted band size: 30 kDa
![OI-RD Scanning - Anti-CSN7A antibody [EPR6463] (ab124705), expandable thumbnail](https://content.abcam.com/products/images/csn7a-antibody-epr6463-ab124705--oi-rd-scanning-img86463.jpg "OI-RD Scanning - Anti-CSN7A antibody [EPR6463] (ab124705)")
OI-RD Scanning - Anti-CSN7A antibody [EPR6463] (ab124705)
We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody.
Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
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