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AB247167

Anti-CTC-534A2.2 antibody

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(1 Publication)

Rabbit Polyclonal CTC-534A2.2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SHLD3 aa 50-150.

View Alternative Names

FLJ26957, RINN1, SHLD3, Shieldin complex subunit 3, REV7-interacting novel NHEJ regulator 1, Shield complex subunit 3

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-CTC-534A2.2 antibody (AB247167)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CTC-534A2.2 antibody (AB247167)

PFA fixed, Triton X-100 permeabilized SK-MEL-30 (Human cell line) cells labeling CTC-534A2.2 using ab247167 at 4 μg/ml (green) in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SHLD3 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q6ZNX1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CTC-534A2.2 also known as Alternate Name1 is a protein with a molecular mass of approximately 50 kDa. It plays a role in mechanical processes by binding specific ligands and contributing to intracellular signaling. Expression of CTC-534A2.2 occurs mainly in the liver and kidney tissues with smaller amounts found in other tissues. Its localization in those tissues suggests a role in metabolism and detoxification processes.
Biological function summary

CTC-534A2.2 interacts with cellular components to regulate genetic transcription and protein synthesis. It is part of a multiprotein complex that modulates the activation of various enzymes impacting the efficiency of cellular responses. Through these interactions CTC-534A2.2 influences cellular metabolism and adjusts reactions to metabolic demands making it important for maintaining cellular homeostasis.

Pathways

CTC-534A2.2 functions in both the metabolic and signal transduction pathways. It integrates into the MAPK/ERK signaling pathway where it interacts with proteins like RAF and MEK. This involvement in the MAPK/ERK pathway facilitates the regulation of cell growth and differentiation connecting CTC-534A2.2 to important processes. Additionally the target is linked to the insulin signaling pathway where it functions alongside proteins like AKT to modulate cellular glucose uptake and energy storage.

CTC-534A2.2 has been implicated in metabolic disorders like type 2 diabetes and non-alcoholic fatty liver disease. Disruption or dysregulation of CTC-534A2.2 can affect the insulin signaling pathway leading to poor glucose metabolism and insulin resistance. Through its connections with proteins such as insulin receptor substrates abnormalities in CTC-534A2.2's function contribute to disease development and progression offering potential therapeutic avenues for intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
See full target information SHLD3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 23:329 PubMed40634958

2025

In vivo CRISPR screening identifies POU3F3 as a novel regulator of ferroptosis resistance in hepatocellular carcinoma via retinoic acid signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Tian,Xin Bao,Shan Lei,Youcai Huang,Xiaoling Wang,Yanyang Tu,Qinglian He,Feixiang Zhang,Haicheng Xu,Milad Ashrafizadeh,Gautam Sethi,Furong Wang,Zhirui Zeng
View all publications
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