AB136038

Anti-CTDSP1 antibody

Name: Anti-CTDSP1 antibody (ab136038) | Abcam
Brand: Abcam Limited
SKU: AB136038
Price: 520 USD
Availability: InStock

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Polyclonal CTDSP1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CTDSP1.

View Alternative Names

NIF3, NLIIF, SCP1, CTDSP1, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, Nuclear LIM interactor-interacting factor 3, Small C-terminal domain phosphatase 1, NLI-IF, NLI-interacting factor 3, Small CTD phosphatase 1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human CTDSP1. The exact immunogen used to generate this antibody is proprietary information.

Q9GZU7

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CTDSP1 also known as CTD small phosphatase 1 functions as an enzyme that dephosphorylates the C-terminal domain (CTD) of RNA polymerase II. This process regulates transcription elongation and termination. CTDSP1 has a molecular mass of approximately 30 kDa. The protein expresses widely with high levels found in the brain and ovary. It primarily operates within the nucleus reflecting its role in transcription regulation.

Biological function summary

CTDSP1 is involved in gene expression regulation by influencing RNA polymerase II activity. It belongs to a phosphatase family with related proteins like CTDSP2 and CTDSPL sharing overlapping functions. As a part of the CTD phosphatase complex CTDSP1 coordinates with other molecular players to manage gene expression outputs. This regulatory mechanism helps modulate responses to external and internal cellular signals.

Pathways

CTDSP1 takes part in the larger RNA transcription and processing pathways particularly the regulation of RNA polymerase II transcription. CTDSP1 interacts with factors like pre-mRNA splicing components affecting gene expression outcomes. It is associated with pathways that involve Cyclin-dependent kinase 9 (CDK9) which also influences RNA polymerase II activity through phosphorylation events demonstrating its key physiological interactions.

CTDSP1 has associations with neurological conditions and cancer. Its involvement in modulating gene expression links it to neurodegenerative disorders like Alzheimer's disease where transcription regulation plays a significant role in disease progression. Additionally changes in CTDSP1 activity relate to tumorigenesis with alterations in CTDSP1 or interacting proteins like CTDSP2 observed in various cancers. This makes CTDSP1 an interesting target for further research into diagnostic and therapeutic applications.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

See full target information CTDSP1

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BMC biology 22:83 PubMed38609948

2024

Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Svetlana B Panina,Joshua V Schweer,Qian Zhang,Gaurav Raina,Haley A Hardtke,Seungjin Kim,Wanjie Yang,Dionicio Siegel,Y Jessie Zhang

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CTDSP1 antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise