Rabbit Polyclonal Ctip2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 52 publications.
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- Journal of neuroinflammation 20:1082023Preclinical investigation in FAAH inhibition as a neuroprotective therapy for frontotemporal dementia using TDP-43 transgenic male mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIrene Santos-García,Carmen Rodríguez-Cueto,Patricia Villegas,Fabiana Piscitelli,Anna Lauritano,Che-Kun J Shen,Vincenzo Di Marzo,Javier Fernández-Ruiz,Eva de LagoPubMed 37149645
- The Journal of neuroscience : the official journal of the Society for Neuroscience 43:1871-18872023Cbln1 Directs Axon Targeting by Corticospinal Neurons Specifically toward Thoraco-Lumbar Spinal Cord.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJanet H T Song,Carolin Ruven,Payal Patel,Frances Ding,Jeffrey D Macklis,Vibhu SahniPubMed 36823038
- Frontiers in neuroscience 17:11001212023Differential impacts of heterozygosity and null homozygosity on axon and myelinated fiber development in mouse.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCarmen Cifuentes-Diaz,Giorgia Canali,Marta Garcia,Mélanie Druart,Taylor Manett,Mythili Savariradjane,Camille Guillaume,Corentin Le Magueresse,Laurence GoutebrozePubMed 36793543
- Nature communications 14:822023An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNoelle A Sterling,Jun Young Park,Raehee Park,Seo-Hee Cho,Seonhee KimPubMed 36604424
- Scientific reports 12:170102022A novel assessment of fine-motor function reveals early hindlimb and detectable forelimb deficits in an experimental model of ALS.Applications:Unspecified applicationReactive species:Unspecified reactive speciesC Sahara Khademullah,Yves De KoninckPubMed 36220871
- Nature cancer 3:1088-11042022METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiangyu Zeng,Fei Zhao,Gaofeng Cui,Yong Zhang,Rajashree A Deshpande,Yuping Chen,Min Deng,Jake A Kloeber,Yu Shi,Qin Zhou,Chao Zhang,Jing Hou,Wootae Kim,Xinyi Tu,Yuanliang Yan,Zhijie Xu,Lifeng Chen,Huanyao Gao,Guijie Guo,Jiaqi Liu,Qian Zhu,Yueyu Cao,Jinzhou Huang,Zheming Wu,Shouhai Zhu,Ping Yin,Kuntian Luo,Georges Mer,Tanya T Paull,Jian Yuan,Kaixiong Tao,Zhenkun LouPubMed 36138131
- Molecular and cellular neurosciences 123:1037702022Expression of the human herpesvirus 6A latency-associated transcript U94A impairs cytoskeletal functions in human neural cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJessica M Hogestyn,Garrick Salois,Li Xie,Connor Apa,Justin Youngyunpipatkul,Christoph Pröschel,Margot Mayer-PröschelPubMed 36055520
- Scientific reports 12:60222022Heterogeneous fates of simultaneously-born neurons in the cortical ventricular zone.Applications:Unspecified applicationReactive species:Unspecified reactive speciesElia Magrinelli,Natalia Baumann,Robin Jan Wagener,Christelle Glangetas,Camilla Bellone,Denis Jabaudon,Esther KlinglerPubMed 35411060
- Frontiers in cell and developmental biology 10:7326822022Hyperoxygenation During Mid-Neurogenesis Accelerates Cortical Development in the Fetal Mouse Brain.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFranz Markert,Alexander StorchPubMed 35372333
- Cells 11:2022TRIM32 Deficiency Impairs the Generation of Pyramidal Neurons in Developing Cerebral Cortex.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYan-Yun Sun,Wen-Jin Chen,Ze-Ping Huang,Gang Yang,Ming-Lei Wu,De-En Xu,Wu-Lin Yang,Yong-Chun Luo,Zhi-Cheng Xiao,Ru-Xiang Xu,Quan-Hong MaPubMed 35159260
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98.98% PBS, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
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Reactivity data
Select an application| IP | WB | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
IP
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
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Target data
Function
Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity).
Alternative names
CTIP2, RIT1, BCL11B, B-cell lymphoma/leukemia 11B, BCL-11B, B-cell CLL/lymphoma 11B, COUP-TF-interacting protein 2, Radiation-induced tumor suppressor gene 1 protein, hRit1
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Rabbit Polyclonal Ctip2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 52 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 98.98% PBS, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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Full details and terms and conditions can be found here:
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2 product images
Immunoprecipitation - Anti-Ctip2 antibody (ab28448)
Ctip2 was immunoprecipitated using 0.5mg Jurkat whole cell extract, 5µg of Rabbit polyclonal to Ctip2 and 50µl of protein G magnetic beads (+). No antibody was added to the control (-).
The antibody was incubated under agitation with Protein G beads for 10min, Jurkat whole cell extract lysate diluted in RIPA buffer was added to each sample and incubated for a further 10min under agitation.
Proteins were eluted by addition of 40µl SDS loading buffer and incubated for 10min at 70oC; 10µl of each sample was separated on a SDS PAGE gel, transferred to a nitrocellulose membrane, blocked with 5% BSA and probed with ab28448.
Secondary: Mouse monoclonal [SB62a] Secondary Antibody to Rabbit IgG light chain (HRP) (Mouse monoclonal [SB62a] Anti-Rabbit IgG light chain (HRP) ab99697).
Bands: 125, 130kDa: Ctip2.All lanes: Immunoprecipitation - Anti-Ctip2 antibody (ab28448)
Predicted band size: 96 kDa
Western blot - Anti-Ctip2 antibody (ab28448)
All lanes: Western blot - Anti-Ctip2 antibody (ab28448) at 1 µg/mL
Lane 1: Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate at 10 µg
Lane 2: Jurkat nuclear extract lysate (ab14844) at 10 µg
SecondaryAll lanes: Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
Performed under reducing conditions.
Predicted band size: 96 kDa
Observed band size: 125 kDa, 130 kDa
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