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Rabbit Recombinant Monoclonal CTNNA2 antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications.


Images

Western blot - Anti-CTNNA2 antibody [EPR1795] (AB76015), expandable thumbnail

Publications

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA

Form
Liquid
Clonality
Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
Flow CytWBIHC-P
Human
Not recommended
Predicted
Not recommended
Mouse
Not recommended
Tested
Not recommended
Rat
Not recommended
Predicted
Not recommended

Not recommended
Not recommended

Species
Mouse, Rat, Human
Dilution info
-
Notes

-

Tested
Tested

Species
Mouse
Dilution info
1/2000
Notes

-

Predicted
Predicted

Species
Rat, Human
Dilution info
-
Notes

-

Not recommended
Not recommended

Species
Mouse, Rat, Human
Dilution info
-
Notes

-

Target data

Function

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).

Alternative names

CAPR, CTNNA2, Catenin alpha-2, Alpha N-catenin, Alpha-catenin-related protein

Recommended products

Rabbit Recombinant Monoclonal CTNNA2 antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Monoclonal
Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Clone number
EPR1795
Purification technique
Affinity purification Protein A
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Notes

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

CTNNA2 also known as alpha-N-catenin is a protein that plays a mechanical role in cellular adhesion. This protein has a mass of approximately 102 kDa. CTNNA2 localizes at adherens junctions and is expressed in various tissues with a high prominence in the nervous system. It connects the actin cytoskeleton to cadherin complexes facilitating cell-cell interactions that are essential for maintaining tissue integrity.

Biological function summary

CTNNA2 contributes significantly to cellular signaling and structural maintenance. It forms part of the cadherin-catenin complex important in linking cadherins to the actin cytoskeleton. This complex supports the stability and function of cellular junctions enabling communication between cells and influencing cell shape and polarity. The protein's role in the nervous system suggests its involvement in synaptic connectivity and plasticity.

Pathways

CTNNA2 participates in the Wnt signaling and the actin cytoskeleton regulation pathways. These pathways are vital for cellular growth differentiation and motility. In the Wnt signaling pathway CTNNA2 interacts with beta-catenin to regulate gene transcription and cell fate decisions. Its involvement in actin cytoskeleton regulation implicates it in coordination with actin filament dynamics sharing relations with actin-binding proteins like alpha-actinin.

Associated diseases and disorders

CTNNA2 has connections with neurological disorders such as autism and intellectual disability. Alterations in its function or expression can disrupt neural development and synaptic function leading to cognitive impairments. Additionally CTNNA2 links to other proteins implicated in these conditions such as beta-catenin which is known to affect neural development and psychiatric conditions.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Western blot - Anti-CTNNA2 antibody [EPR1795] (ab76015), expandable thumbnail

    Western blot - Anti-CTNNA2 antibody [EPR1795] (ab76015)

    All lanes: Western blot - Anti-CTNNA2 antibody [EPR1795] (ab76015) at 1/2000 dilution

    All lanes: mouse brain lysate at 10 µg

    Secondary

    All lanes: Goat anti-rabbit HRP at 1/2000 dilution

    Predicted band size: 105 kDa

    Observed band size: 102 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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