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AB96184

Anti-CTNNAL1 antibody

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(5 Publications)

Rabbit Polyclonal CTNNAL1 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Alpha-catulin aa 250-550.

View Alternative Names

Alpha-catulin, Alpha-catenin-related protein, Catenin alpha-like protein 1, ACRP, CTNNAL1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTNNAL1 antibody (AB96184)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTNNAL1 antibody (AB96184)

ab96184, at 1/100 dilution, staining CTNNAL1 in paraffin-embedded SW480 xenograft by Immunohistochemistry.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTNNAL1 antibody (AB96184)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTNNAL1 antibody (AB96184)

Immunohistochemical analysis of paraffin-embedded mouse cervix tissue labelling Alpha-catulin protein at cytoplasm with ab96184 at a 1/500 dilution.

Antigen retrieval : Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Western blot - Anti-CTNNAL1 antibody (AB96184)
  • WB

Unknown

Western blot - Anti-CTNNAL1 antibody (AB96184)

7.5% SDS-PAGE

All lanes:

Western blot - Anti-CTNNAL1 antibody (ab96184) at 1/1000 dilution

Lane 1:

HeLa whole cell lysate at 30 µg

Lane 2:

HepG2 whole cell lysate at 30 µg

Predicted band size: 82 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Alpha-catulin aa 250-550. The exact immunogen used to generate this antibody is proprietary information.

Q9UBT7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CTNNAL1 also referred to as catenin alpha-like 1 is a protein with a mass of approximately 100 kDa. It is expressed in various tissues including the brain and testis. This protein plays a role in cell adhesion and cytoskeletal organization by interacting with other cellular components. CTNNAL1 is involved in serving as a linker molecule that connects the cytoskeleton to the extracellular matrix maintaining the structural integrity of cells.
Biological function summary

CTNNAL1 contributes to cellular processes through its role in cell-cell adhesion and signaling pathways. It does not function alone but rather as part of a multi-protein complex involving proteins such as beta-catenin and alpha-catenin. This complex formation is essential for stabilizing cell junctions and facilitating communication between cells. Through its interactions CTNNAL1 maintains cellular architecture and supports signal transduction essential for tissue development and maintenance.

Pathways

CTNNAL1 participates in the Wnt signaling and adherens junction pathways. In the Wnt signaling pathway CTNNAL1 influences beta-catenin activity a critical protein for signal transduction and gene expression regulation. In the adherens junction pathway CTNNAL1 works closely with alpha-catenin to mediate cell adhesion processes that are important for tissue structure and cellular communication.

CTNNAL1 has associations with cancer and neurodevelopmental disorders. Alterations in CTNNAL1 expression or function can impact cell adhesion and signaling contributing to cancer progression particularly in the context of aberrant Wnt signaling which involves beta-catenin as an important player. Additionally disruptions to the proteins' role in neural tissue can lead to neurodevelopmental issues often linked to irregularities in cellular structure and signaling within the central nervous system.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
See full target information Alpha-catulin
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:28479 PubMed40760141

2025

Bioinformatics analysis of Rho-signal transduction genes in postmenopausal osteoporosis and periodontitis.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Qi,E Liu,Yunqing Pang,Yu Wang,Jing Wang

Alzheimer's research & therapy 17:166 PubMed40684176

2025

Periodontitis-induced neuroinflammation triggers IFITM3-Aβ axis to cause alzheimer's disease-like pathology and cognitive decline.

Applications

Unspecified application

Species

Unspecified reactive species

Lingwenyao Kong,Juanjuan Li,Lu Gao,Yonggang Zhao,Weixian Chen,Xumeng Wang,Songlin Wang,Fu Wang

Acta biochimica et biophysica Sinica 55:1618-1629 PubMed37715489

2023

CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma mouse model through ROCK1-CAL signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Di Wu,Jiahui Zhu,Fang Yang,Riwang Li,Lexin Liu,Dahai Liu,Chi Liu,Xiangping Qu,Huijun Liu,Ming Ji,Xiaoqun Qin,Lan Hua,Yang Xiang

Journal of cellular and molecular medicine 26:1656-1671 PubMed35092120

2022

CTNNAL1 participates in the regulation of mucus overproduction in HDM-induced asthma mouse model through the YAP-ROCK2 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Di Wu,Wang Jiang,Caixia Liu,Lexin Liu,Furong Li,Xiaodi Ma,Lang Pan,Chi Liu,Xiangping Qu,Huijun Liu,Xiaoqun Qin,Yang Xiang

Experimental physiology 103:1157-1169 PubMed29791759

2018

CTNNAL1 inhibits ozone-induced epithelial-mesenchymal transition in human bronchial epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Meiling Tan,Caixia Liu,Wenjie Huang,Linhong Deng,Xiaoqun Qin,Yang Xiang
View all publications
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Product promise

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