Rabbit Polyclonal CTNNAL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Alpha-catulin aa 250-550.
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Publications
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- Journal of cellular and molecular medicine 26:1656-16712022CTNNAL1 participates in the regulation of mucus overproduction in HDM-induced asthma mouse model through the YAP-ROCK2 pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDi Wu,Wang Jiang,Caixia Liu,Lexin Liu,Furong Li,Xiaodi Ma,Lang Pan,Chi Liu,Xiangping Qu,Huijun Liu,Xiaoqun Qin,Yang XiangPubMed 35092120
- Experimental physiology 103:1157-11692018CTNNAL1 inhibits ozone-induced epithelial-mesenchymal transition in human bronchial epithelial cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMeiling Tan et. al.PubMed 29791759
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human Alpha-catulin aa 250-550. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UBT7
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
Target data
Function
May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
Alternative names
Alpha-catulin, Alpha-catenin-related protein, Catenin alpha-like protein 1, ACRP, CTNNAL1
Recommended products
Rabbit Polyclonal CTNNAL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Alpha-catulin aa 250-550.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human Alpha-catulin aa 250-550. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UBT7
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CTNNAL1 also referred to as catenin alpha-like 1 is a protein with a mass of approximately 100 kDa. It is expressed in various tissues including the brain and testis. This protein plays a role in cell adhesion and cytoskeletal organization by interacting with other cellular components. CTNNAL1 is involved in serving as a linker molecule that connects the cytoskeleton to the extracellular matrix maintaining the structural integrity of cells.
- Biological function summary
CTNNAL1 contributes to cellular processes through its role in cell-cell adhesion and signaling pathways. It does not function alone but rather as part of a multi-protein complex involving proteins such as beta-catenin and alpha-catenin. This complex formation is essential for stabilizing cell junctions and facilitating communication between cells. Through its interactions CTNNAL1 maintains cellular architecture and supports signal transduction essential for tissue development and maintenance.
- Pathways
CTNNAL1 participates in the Wnt signaling and adherens junction pathways. In the Wnt signaling pathway CTNNAL1 influences beta-catenin activity a critical protein for signal transduction and gene expression regulation. In the adherens junction pathway CTNNAL1 works closely with alpha-catenin to mediate cell adhesion processes that are important for tissue structure and cellular communication.
- Associated diseases and disorders
CTNNAL1 has associations with cancer and neurodevelopmental disorders. Alterations in CTNNAL1 expression or function can impact cell adhesion and signaling contributing to cancer progression particularly in the context of aberrant Wnt signaling which involves beta-catenin as an important player. Additionally disruptions to the proteins' role in neural tissue can lead to neurodevelopmental issues often linked to irregularities in cellular structure and signaling within the central nervous system.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-CTNNAL1 antibody (ab96184)
7.5% SDS-PAGE
All lanes: Western blot - Anti-CTNNAL1 antibody (ab96184) at 1/1000 dilution
Lane 1: HeLa whole cell lysate at 30 µg
Lane 2: HepG2 whole cell lysate at 30 µg
Predicted band size: 82 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTNNAL1 antibody (ab96184)
ab96184, at 1/100 dilution, staining CTNNAL1 in paraffin-embedded SW480 xenograft by Immunohistochemistry.
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