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AB235053

Anti-CTRB1 antibody

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(2 Publications)

Rabbit Polyclonal CTRB1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CTRB1.

View Alternative Names

CTRB, CTRB1, Chymotrypsinogen B

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTRB1 antibody (AB235053)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTRB1 antibody (AB235053)

Paraffin-embedded human pancreatic tissue stained for CTRB1 using ab235053 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-CTRB1 antibody (AB235053)
  • WB

Supplier Data

Western blot - Anti-CTRB1 antibody (AB235053)

All lanes:

Western blot - Anti-CTRB1 antibody (ab235053) at 1/500 dilution

Lane 1:

Mouse spleen tissue lysate

Lane 2:

Mouse stomach tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 28 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CTRB1.

P17538

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CTRB1 also known as Chymotrypsinogen B1 is a serine protease with approximately 30 kDa mass. This enzyme is mainly expressed in the pancreas and plays a significant role in protein digestion. It is synthesized as an inactive form chymotrypsinogen which requires activation into its active form by trypsin. The target's main function is to break down proteins into smaller peptide chains which are further processed during digestion.
Biological function summary

CTRB1 acts as an essential digestive enzyme within the larger scope of the digestive system. It does not operate within a known complex but it collaborates with other digestive enzymes to ensure efficient protein digestion. The activation and subsequent activity of CTRB1 is a finely regulated process important for properly breaking down dietary proteins into amino acids. This function supports nutrient absorption in the small intestine.

Pathways

Digestion and nutrient assimilation are direct applications of CTRB1 activities. It plays a role within the proteolytic enzyme digestion pathway working alongside trypsin and chymotrypsin to digest proteins. Furthermore it interconnects with other pancreatic enzymes in complex interactions that contribute to the complete digestion of dietary substances.

CTRB1 implications include pancreatic disorders such as pancreatitis. Misregulation or genetic variation in CTRB1 may contribute to the onset of pancreatic diseases where proteolytic balance is disrupted. Additionally CTRB1 interacts indirectly with genetic syndromes linked to enzyme deficiencies revealing its broader clinical relevance in digestive health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information CTRB1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Discover oncology 16:489 PubMed40198509

2025

Acinar cells modulate the tumor microenvironment through the promotion of M1 macrophage polarization via macrophage endocytosis in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Congjia Ma,Wenbo Zhu,Xiulin Hu,Deli Wu,Xintong Zhao,Yiqi Du,Xiangyu Kong

Journal of diabetes investigation 12:334-345 PubMed32881354

2020

Micro-ribonucleic acid-23a-3p prevents the onset of type 2 diabetes mellitus by suppressing the activation of nucleotide-binding oligomerization-like receptor family pyrin domain containing 3 inflammatory bodies-caused pyroptosis through negatively regulating NIMA-related kinase 7.

Applications

Unspecified application

Species

Unspecified reactive species

Hongye Chang,Hongjuan Chang,Tuanjie Cheng,Garrick D Lee,Xiaoping Chen,Kunqing Qi
View all publications
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Product promise

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