AB157219

Anti-CTRL antibody [EPR11490(B)]

RabMAb
Recombinant
What is this?

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(1 Publication)

Rabbit Recombinant Monoclonal CTRL antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.

View Alternative Names

CTRL1, CTRL, Chymotrypsin-like protease CTRL-1

1 Images

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Western blot - Anti-CTRL antibody [EPR11490(B)] (AB157219)

All lanes:

Western blot - Anti-CTRL antibody [EPR11490(B)] (ab157219) at 1/10000 dilution

Lane 1:

Mouse pancreas lysate at 10 µg

Lane 2:

Rat pancreas lysate at 10 µg

Lane 3:

Human fetal pancreas lysate at 10 µg

Predicted band size: 28 kDa

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Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11490(B)

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CTRL protein also known as chymotrypsin-like protease CTRL-1 functions primarily as a serine protease. It exhibits a catalytic domain typical of the Chymotrypsin family of serine proteases. With a mass of approximately 29 kDa CTRL is expressed prominently in pancreatic tissue but can also be found in other tissues at lower levels. It plays a role in protein degradation by cleaving at specific amino acid sites.

Biological function summary

The serine protease activity of CTRL contributes to the digestion process by breaking down protein chains into smaller peptides. It does not work alone but rather as part of a larger complex. This involvement makes it integral to maintaining protein homeostasis in the body. It's expressed in various cellular processes that require the precise breakdown of polypeptides emphasizing its importance in tissue maintenance and repair.

Pathways

CTRL is involved in the proteolytic pathway facilitating the breakdown of dietary proteins into absorbable units. It collaborates closely with other proteases such as trypsin that complement its function by targeting different peptide bonds. Additionally CTRL takes part in cellular metabolism pathways where it assists in processing proteins needed for cellular activities.

Dysfunctional CTRL activity associates with digestive disorders such as pancreatitis. An imbalance in its activity can also contribute to the development of pancreatic insufficiencies. In these contexts CTRL interacts with proteins like elastase where altered activity levels can exacerbate tissue damage during inflammatory conditions. Understanding CTRL's precise role provides insights into potential therapeutic targets for managing certain pathologies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information CTRL

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International heart journal 64:750-758 PubMed37518356

2023

LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models.

Applications

Unspecified application

Species

Unspecified reactive species

Junqi Xiao,Yang Xie,Qing Duan,Tao Liu,Rong Ye,Xunhong Duan,Zhibiao Le,Nan Deng,Fengen Liu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CTRL antibody [EPR11490(B)]

Western blot - Anti-CTRL antibody [EPR11490(B)] (AB157219)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise