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AB121791

Anti-CTRP12 antibody

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(1 Publication)

Rabbit Polyclonal CTRP12 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human C1QTNF12 aa 50-150.

View Alternative Names

C1QDC2, CTRP12, FAM132A, C1QTNF12, Adipolin, Adipose-derived insulin-sensitizing factor, C1q and TNF related protein 12, Complement C1q tumor necrosis factor-related protein 12

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTRP12 antibody (AB121791)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTRP12 antibody (AB121791)

ab121791, at 1/75 dilution, staining CTRP12 in paraffin-embedded Human colon tissue, by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human C1QTNF12 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

Q5T7M4

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Complementary Products

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AB121532

Anti-FAM73A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM73A antibody (AB121532)

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Primary Antibodies

AB121343

Anti-HEG1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HEG1 antibody (AB121343)

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Primary Antibodies

AB121348

Anti-FAM159B antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM159B antibody (AB121348)

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Primary Antibodies

AB121991

Anti-HENMT1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HENMT1 antibody (AB121991)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C1q/TNF-related protein 12 (CTRP12) also known as adipolin or C1qDC2 is a secreted protein with a molecular weight of approximately 33 kDa. It is mainly expressed in adipose tissue and is also found in skeletal muscle and the liver. Mechanically CTRP12 belongs to the adipokine family which typically regulates metabolic processes. It functions as a signaling molecule and has homology to complement C1Q proteins and TNF ligands.
Biological function summary

CTRP12 impacts several metabolic pathways. It plays a role in glucose metabolism insulin sensitivity and energy homeostasis. CTRP12 is not part of a complex but interacts with receptors and other molecules to mediate its effects. Its expression increases during adipocyte differentiation which suggests a direct link with adipogenesis.

Pathways

Adipokines like CTRP12 integrate into the insulin signaling and AMP-activated protein kinase (AMPK) pathways. In these processes CTRP12 works closely with proteins such as insulin receptor substrate (IRS) and adenosine monophosphate-activated protein kinase (AMPK) to enhance metabolic activity and maintain energy balance. By promoting insulin action and glucose uptake CTRP12 contributes to the overall regulation of glucose levels.

CTRP12 associates with obesity and type 2 diabetes. This connection arises because these conditions often involve impaired insulin signaling and disrupted metabolic activities areas where CTRP12 functions actively. Related proteins like adiponectin and leptin interact in these pathological contexts indicating that CTRP12 participates in a network of regulatory adipokines that influence disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.
See full target information C1QTNF12
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 9:684259 PubMed34307361

2021

Development and Validation of a Ferroptosis-Related Gene Signature for Overall Survival Prediction in Lung Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Tian,Yan Zhou,Lizhe Zhu,Huan Gao,Jin Yang
View all publications
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Product promise

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