AB36870

Anti-CTRP3 antibody

Name: Anti-CTRP3 antibody (ab36870) | Abcam
Brand: Abcam Limited
SKU: AB36870
Price: 535 USD
Availability: InStock

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(19 Publications)

Rabbit Polyclonal CTRP3 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse samples. Cited in 19 publications. Immunogen corresponding to Synthetic Peptide within Human C1QTNF3.

View Alternative Names

CTRP3, UNQ753/PRO1484, C1QTNF3, Complement C1q tumor necrosis factor-related protein 3, Collagenous repeat-containing sequence 26 kDa protein, Secretory protein CORS26, CORS26

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTRP3 antibody (AB36870)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTRP3 antibody (AB36870)

ab36870 at 2μg/ml staining CTRP3 in mouse heart tissue by IHC

Immunocytochemistry/ Immunofluorescence - Anti-CTRP3 antibody (AB36870)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CTRP3 antibody (AB36870)

Immunofluorescence of CTRP3 in Mouse Heart cells using ab36870 at 10 ug/ml.

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Western blot - Anti-CTRP3 antibody (AB36870)

In lane 1 (left) no blocking peptide present; in lane 2 (right) blocking peptide is present. These proteins are often highly modified post-translationally and may migrate in SDS-PAGE at positions other than their predicted size.

All lanes:

Western blot - Anti-CTRP3 antibody (ab36870) at 1 µg/mL

All lanes:

Mouse heart cell lysate

Predicted band size: 27 kDa

Observed band size: 36 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human C1QTNF3. The exact immunogen used to generate this antibody is proprietary information.

Q9BXJ4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CTRP3 also known as C1q/TNF-related protein 3 or Cartducin is a secreted protein with a molecular mass of approximately 25 kDa. This protein expresses in various tissues including adipose tissue liver and cartilage. The presence of CTRP3 in these diverse tissues suggests its involvement in various physiological processes. As a member of the CTRP family CTRP3 shares a conserved C1q domain which indicates potential functional similarities with other family members.

Biological function summary

The activity of CTRP3 impacts metabolic regulation and anti-inflammatory responses. Its action is not associated directly with a complex but it interacts with multiple signaling molecules and pathways. In adipocytes CTRP3 decreases glucose output and enhances insulin signaling. It also possesses anti-inflammatory properties by downregulating pro-inflammatory cytokines contributing to an overall reduced inflammatory state. These biological activities make CTRP3 a significant protein in metabolic homeostasis and immune response modulation.

Pathways

CTRP3 influences several mechanisms such as the insulin signaling pathway and the NF-kB signaling pathway. By interacting with proteins like Akt and AMPK within the insulin pathway CTRP3 enhances glucose uptake and utilization. It also modulates NF-kB activity suppressing inflammatory responses suggesting a protective role against chronic inflammation. These actions demonstrate CTRP3’s integration into important systems that coordinate metabolic health and immune function.

CTRP3 has connections to metabolic syndrome and osteoarthritis. Its role in metabolic regulation ties it with insulin resistance a core feature of metabolic syndrome. CTRP3 improves insulin sensitivity potentially mitigating associated disorders. In osteoarthritis its anti-inflammatory effect can influence disease progression by reducing inflammation in joint tissues. Proteins such as adiponectin and leptin are involved in these contexts with CTRP3 interacting functionally with them suggesting possible therapeutic targets for managing disease conditions linked to metabolic and inflammatory dysregulation.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information C1QTNF3

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Publications (19)

Recent publications for all applications. Explore the full list and refine your search

PeerJ 11:e15890 PubMed37637169

2023

CTRP3 attenuates inflammation, oxidative and cell death in cisplatin induced HK-2 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Chenglin Zou,Xun Tang,Tingting Guo,Tingting Jiang,Wenying Zhang,Jun Zhang

Allergologia et immunopathologia 51:31-39 PubMed37422777

2023

CTRP3 regulates NF-κB and TGFβ1/Smad3 pathways to alleviate airway inflammation and remodeling in asthmatic mice induced by OVA.

Applications

Unspecified application

Species

Unspecified reactive species

Hai Lin,Jinrong Yi

Bioengineered 13:6080-6091 PubMed35196182

2022

C1q/tumor necrosis factor-related protein-3 (CTRP3) activated by forkhead box O4 (FOXO4) down-regulation protects retinal pericytes against high glucose-induced oxidative damage through nuclear factor erythroid 2-related factor 2 (Nrf2)/Nuclear factor-kappaB (NF-κB) signaling.

Applications

Unspecified application

Species

Unspecified reactive species

XiuYa Zeng,YouYuan Peng,YanFeng Wang,KeMing Kang

Experimental and therapeutic medicine 23:35 PubMed34849150

2021

Effects and mechanisms of CTRP3 overexpression in secondary brain injury following intracerebral hemorrhage in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Wan,Jieqiong Wang,Bo Yang,Conggai Huang,Xiaoqin Tang,Hong Yi,Yun Liu,Shaohua Wang

Science advances 7:eabg6069 PubMed34797714

2021

CTRP3 exacerbates tendinopathy by dysregulating tendon stem cell differentiation and altering extracellular matrix composition.

Applications

Unspecified application

Species

Unspecified reactive species

Yongsik Cho,Hyeon-Seop Kim,Donghyun Kang,Hyeonkyeong Kim,Narae Lee,Jihye Yun,Yi-Jun Kim,Kyoung Min Lee,Jin-Hee Kim,Hang-Rae Kim,Young-Il Hwang,Chris Hyunchul Jo,Jin-Hong Kim

Experimental biology and medicine (Maywood, N.J.) 247:174-183 PubMed34601891

2021

CTRP3 protects against uric acid-induced endothelial injury by inhibiting inflammation and oxidase stress in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Junxia Zhang,Xue Lin,Jinxiu Xu,Feng Tang,Lupin Tan

Animal bioscience 34:1078-1087 PubMed33152229

2020

Isolation and identification of goose skeletal muscle satellite cells and preliminary study on the function of C1q and tumor necrosis factor-related protein 3 gene.

Applications

Unspecified application

Species

Unspecified reactive species

Han Wang,Ke He,Xuehua Zeng,Xiaolong Zhou,Feifei Yan,Songbai Yang,Ayong Zhao

Bioscience reports 40: PubMed32219332

2020

CTRP3 ameliorates cerulein-induced severe acute pancreatitis in mice via SIRT1/NF-κB/p53 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Chunyang Lv,Yuan He,Mingli Wei,Guiyun Xu,Chuang Chen,Zhen Xu,Zhilong Ding

Scientific reports 10:5425 PubMed32214220

2020

Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Keita Okada,Daisuke Mori,Yuma Makii,Hideki Nakamoto,Yasutaka Murahashi,Fumiko Yano,Song Ho Chang,Yuki Taniguchi,Hiroshi Kobayashi,Hiroaki Semba,Norihiko Takeda,Wen Piao,Kenjiro Hanaoka,Tetsuo Nagano,Sakae Tanaka,Taku Saito

International journal of clinical and experimental 13:142-152 PubMed32211094

2020

MiR-144 affects proliferation and apoptosis of high glucose-induced AC16 cardiomyocytes by regulating CTRP3/JNK signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yanling Song,Huade Mai,Yunyun Lin,Yachun Wang,Xiaoxi Wang,Shenhong Gu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-CTRP3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTRP3 antibody (AB36870)

Immunocytochemistry/ Immunofluorescence - Anti-CTRP3 antibody (AB36870)

Western blot - Anti-CTRP3 antibody (AB36870)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (19)

Complementary Products

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Product promise