AB115455

Anti-CTRP6 antibody

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(3 Publications)

Rabbit Polyclonal CTRP6 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human C1QTNF6 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

CTRP6, UNQ581/PRO1151, C1QTNF6, Complement C1q tumor necrosis factor-related protein 6

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTRP6 antibody (AB115455)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTRP6 antibody (AB115455)

ab115455, at 5 µg/ml, staining CTRP6 in formalin-fixed, paraffin-embedded Human Small Intestine tissue by Immunohistochemistry using a biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTRP6 antibody (AB115455)

ab115455, at 5 μg/ml, staining CTRP6 in formalin-fixed, paraffin-embedded Human Kidney tissue by Immunohistochemistry using a biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human C1QTNF6 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9BXI9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CTRP6 also known as C1q/TNF-related protein 6 is a secreted protein that belongs to the C1q/TNF-related protein family. It has a molecular mass of approximately 37 kDa. Expression of CTRP6 occurs in various tissues including adipose tissue skeletal muscle and liver. Its structural components include a collagen-like domain and a C1q globular domain which are characteristic of proteins involved in immune responses and metabolic regulation.

Biological function summary

CTRP6 plays a significant role in modulating inflammatory responses and metabolism. It acts by influencing the secretion and activity of cytokines such as IL-6 and TNF-alpha. Although not frequently noted as part of a multi-protein complex CTRP6 interacts closely with signaling molecules to achieve its functions. Studies suggest its involvement in maintaining metabolic balance and regulating insulin sensitivity key processes in various physiological states.

Pathways

It interacts with several metabolic and inflammatory signaling cascades. This protein mediates effects through pathways like the AMPK signaling pathway which plays an important role in energy balance and metabolic stress responses. CTRP6 is also linked to the TLR4 signaling pathway involved in immune activation and inflammation. These pathways involve interactions with various proteins such as AMPK and TLR4 receptors highlighting its integrative role in cell signaling networks.

CTRP6 shows an association with conditions like obesity and type 2 diabetes. These diseases link to its role in regulating metabolic and inflammatory responses. Dysfunctional CTRP6 expression or activity has been observed in individuals with these metabolic disorders. Additionally CTRP6 relates to the expression and regulation of proteins such as adiponectin and TNF-alpha which are also involved in these disease pathways. These connections emphasize its potential as a therapeutic target for metabolic interventions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information C1QTNF6

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of nanobiotechnology 23:409 PubMed40457410

2025

Targeted tumor cell-intrinsic CTRP6 biomimetic codelivery synergistically amplifies ferroptosis and immune activation to boost anti-PD-L1 immunotherapy efficacy in lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Songhua Cai,Jing Huang,Hongjie Fan,Zhilin Sui,Chujian Huang,Youjun Deng,Ran Jia,Lixu Wang,Kai Ma,Xiaotong Guo,Jie He,Baihua Zhang,Zhentao Yu

Cancer cell international 21:666 PubMed34906149

2021

C1QTNF6 promotes oral squamous cell carcinoma by enhancing proliferation and inhibiting apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaobin Song,Longjie Li,Liang Shi,Xinyu Liu,Xun Qu,Fengcai Wei,Ketao Wang

Experimental and therapeutic medicine 7:423-428 PubMed24396418

2014

Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Feng,Jun-Feng Liu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CTRP6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTRP6 antibody (AB115455)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTRP6 antibody (AB115455)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise