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AB36898

Anti-CTRP6 antibody

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(3 Publications)

Rabbit Polyclonal CTRP6 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human C1QTNF6.

View Alternative Names

CTRP6, UNQ581/PRO1151, C1QTNF6, Complement C1q tumor necrosis factor-related protein 6

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-CTRP6 antibody (AB36898)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CTRP6 antibody (AB36898)

ab36898 at 10μg/ml staining CTRP6 in Hela cells by ICC/IF

Immunocytochemistry/ Immunofluorescence - Anti-CTRP6 antibody (AB36898)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CTRP6 antibody (AB36898)

Immunofluorescence of CTRP6 in Hela cells using ab36898 at 20 ug/ml.

Western blot - Anti-CTRP6 antibody (AB36898)
  • WB

Unknown

Western blot - Anti-CTRP6 antibody (AB36898)

These proteins often migrate in SDS-PAGE at positions other than their predicted size.

Lane 1:

Western blot - Anti-CTRP6 antibody (ab36898) at 1 µg/mL

Lane 2:

Western blot - Anti-CTRP6 antibody (ab36898) at 2 µg/mL

All lanes:

Hela cell lysate

Predicted band size: 29 kDa

Observed band size: 42 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human C1QTNF6. The exact immunogen used to generate this antibody is proprietary information.

Q9BXI9

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CTRP6 also known as C1q/TNF-related protein 6 is a secreted protein that belongs to the C1q/TNF-related protein family. It has a molecular mass of approximately 37 kDa. Expression of CTRP6 occurs in various tissues including adipose tissue skeletal muscle and liver. Its structural components include a collagen-like domain and a C1q globular domain which are characteristic of proteins involved in immune responses and metabolic regulation.
Biological function summary

CTRP6 plays a significant role in modulating inflammatory responses and metabolism. It acts by influencing the secretion and activity of cytokines such as IL-6 and TNF-alpha. Although not frequently noted as part of a multi-protein complex CTRP6 interacts closely with signaling molecules to achieve its functions. Studies suggest its involvement in maintaining metabolic balance and regulating insulin sensitivity key processes in various physiological states.

Pathways

It interacts with several metabolic and inflammatory signaling cascades. This protein mediates effects through pathways like the AMPK signaling pathway which plays an important role in energy balance and metabolic stress responses. CTRP6 is also linked to the TLR4 signaling pathway involved in immune activation and inflammation. These pathways involve interactions with various proteins such as AMPK and TLR4 receptors highlighting its integrative role in cell signaling networks.

CTRP6 shows an association with conditions like obesity and type 2 diabetes. These diseases link to its role in regulating metabolic and inflammatory responses. Dysfunctional CTRP6 expression or activity has been observed in individuals with these metabolic disorders. Additionally CTRP6 relates to the expression and regulation of proteins such as adiponectin and TNF-alpha which are also involved in these disease pathways. These connections emphasize its potential as a therapeutic target for metabolic interventions.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Neural regeneration research 19:2019-2026 PubMed38227531

2024

The action mechanism by which C1q/tumor necrosis factor-related protein-6 alleviates cerebral ischemia/reperfusion injury in diabetic mice.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Zhao,Mei Li,Bingyu Li,Yanan Li,Qianni Shen,Jiabao Hou,Yang Wu,Lijuan Gu,Wenwei Gao

Bioengineered 13:206-216 PubMed34964705

2021

C1q/tumor necrosis factor related protein 6 (CTRP6) regulates the phenotypes of high glucose-induced gestational trophoblast cells via peroxisome proliferator-activated receptor gamma (PPARγ) signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Zhang,Wen-Pei Bai

Marine environmental research 65:427-36 PubMed18342364

2008

Quantitative immunochemical evaluation of fish metallothionein upon exposure to cadmium.

Applications

Unspecified application

Species

Unspecified reactive species

Yana Yudkovski,Adelina Rogowska-Wrzesinska,Irena Yankelevich,Edna Shefer,Barak Herut,Moshe Tom
View all publications

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