AB36900

Anti-CTRP6 antibody

Name: Anti-CTRP6 antibody (ab36900) | Abcam
Brand: Abcam Limited
SKU: AB36900
Price: 490 USD
Availability: InStock

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(9 Publications)

Rabbit Polyclonal CTRP6 antibody. Suitable for WB and reacts with Mouse samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human C1QTNF6.

View Alternative Names

CTRP6, UNQ581/PRO1151, C1QTNF6, Complement C1q tumor necrosis factor-related protein 6

1 Images

Unknown

Western blot - Anti-CTRP6 antibody (AB36900)

These proteins often migrate in SDS-PAGE at positions other than their predicted size.

Lane 1:

Western blot - Anti-CTRP6 antibody (ab36900) at 0.5 µg/mL

Lane 2:

Western blot - Anti-CTRP6 antibody (ab36900) at 1 µg/mL

Lane 3:

Western blot - Anti-CTRP6 antibody (ab36900) at 2 µg/mL

All lanes:

Mouse brain cell lysate

Predicted band size: 29 kDa

Observed band size: 42 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

applications

Immunogen

Synthetic Peptide within Human C1QTNF6. The exact immunogen used to generate this antibody is proprietary information.

Q9BXI9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p>Often migrates in SDS-PAGE at a position other than the predicted size.</p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CTRP6 also known as C1q/TNF-related protein 6 is a secreted protein that belongs to the C1q/TNF-related protein family. It has a molecular mass of approximately 37 kDa. Expression of CTRP6 occurs in various tissues including adipose tissue skeletal muscle and liver. Its structural components include a collagen-like domain and a C1q globular domain which are characteristic of proteins involved in immune responses and metabolic regulation.

Biological function summary

CTRP6 plays a significant role in modulating inflammatory responses and metabolism. It acts by influencing the secretion and activity of cytokines such as IL-6 and TNF-alpha. Although not frequently noted as part of a multi-protein complex CTRP6 interacts closely with signaling molecules to achieve its functions. Studies suggest its involvement in maintaining metabolic balance and regulating insulin sensitivity key processes in various physiological states.

Pathways

It interacts with several metabolic and inflammatory signaling cascades. This protein mediates effects through pathways like the AMPK signaling pathway which plays an important role in energy balance and metabolic stress responses. CTRP6 is also linked to the TLR4 signaling pathway involved in immune activation and inflammation. These pathways involve interactions with various proteins such as AMPK and TLR4 receptors highlighting its integrative role in cell signaling networks.

CTRP6 shows an association with conditions like obesity and type 2 diabetes. These diseases link to its role in regulating metabolic and inflammatory responses. Dysfunctional CTRP6 expression or activity has been observed in individuals with these metabolic disorders. Additionally CTRP6 relates to the expression and regulation of proteins such as adiponectin and TNF-alpha which are also involved in these disease pathways. These connections emphasize its potential as a therapeutic target for metabolic interventions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information C1QTNF6

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Journal of assisted reproduction and genetics 39:2191-2199 PubMed35907048

2022

Prevention of intrauterine fetal growth restriction by administrating C1q/TNF-related protein 6, a specific inhibitor of the alternative complement pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Mayu Kurokawa,Ai Takeshita,Shu Hashimoto,Masayasu Koyama,Yoshiharu Morimoto,Daisuke Tachibana

CNS neuroscience & therapeutics 28:953-963 PubMed35322553

2022

Long non-coding RNA H19 promotes leukocyte inflammation in ischemic stroke by targeting the miR-29b/C1QTNF6 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Guangwen Li,Xiaoqing Ma,Haiping Zhao,Junfen Fan,Tianwei Liu,Yumin Luo,Yunliang Guo

Bioengineered 12:5716-5726 PubMed34516328

2021

CTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6) alleviated the sevoflurane induced injury of mice central nervous system by promoting the expression of p-Akt (phosphorylated Akt).

Applications

Unspecified application

Species

Unspecified reactive species

Zhiwen Liu,Bin Yang

Journal of cellular physiology 236:5785-5800 PubMed33400820

2021

C1q/tumor necrosis factor-related protein-6 attenuates TNF-α-induced apoptosis in salivary acinar cells via AMPK/SIRT1-modulated miR-34a-5p expression.

Applications

Unspecified application

Species

Unspecified reactive species

Ling-Han Qu,Xia Hong,Yan Zhang,Xin Cong,Ruo-Lan Xiang,Mei Mei,Jia-Zeng Su,Li-Ling Wu,Guang-Yan Yu

BioMed research international 2020:7139721 PubMed33123583

2020

C1QTNF6 Overexpression Acts as a Predictor of Poor Prognosis in Bladder Cancer Patients.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Zhu,Hang Tong,Shun Gao,Hubin Yin,Gongmin Zhu,Xinyuan Li,Weiyang He,Xin Gou

Molecular medicine reports 22:344-352 PubMed32377750

2020

Protective effect of CTRP6 on cerebral ischemia/reperfusion injury by attenuating inflammation, oxidative stress and apoptosis in PC12 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Li,Jie Sun,Lei Gu,Xufang Gao

DNA and cell biology 39:1000-1011 PubMed32282241

2020

as a Novel Diagnostic and Prognostic Biomarker for Clear Cell Renal Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wanzun Lin,Xiaochuan Chen,Ting Chen,Jun Liu,Yuling Ye,Long Chen,Xianxin Qiu,Jason Chia-Hsien Cheng,Lurong Zhang,Junxin Wu,Sufang Qiu

International journal of molecular medicine 43:621-629 PubMed30431096

2018

C1QTNF6 is overexpressed in gastric carcinoma and contributes to the proliferation and migration of gastric carcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hai-Xia Qu,Lin Cui,Xin-Ying Meng,Zhi-Jie Wang,Yan-Xin Cui,Yun-Peng Yu,Dong Wang,Xiang-Jun Jiang

Nature communications 6:8483 PubMed26404464

2015

CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Masanori A Murayama,Shigeru Kakuta,Asuka Inoue,Naoto Umeda,Tomo Yonezawa,Takumi Maruhashi,Koichiro Tateishi,Harumichi Ishigame,Rikio Yabe,Satoshi Ikeda,Akimasa Seno,Hsi-Hua Chi,Yuriko Hashiguchi,Riho Kurata,Takuya Tada,Sachiko Kubo,Nozomi Sato,Yang Liu,Masahira Hattori,Shinobu Saijo,Misao Matsushita,Teizo Fujita,Takayuki Sumida,Yoichiro Iwakura

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CTRP6 antibody

Western blot - Anti-CTRP6 antibody (AB36900)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

Product promise