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AB79036

Anti-CUEDC2 antibody

4

(2 Reviews)

|

(2 Publications)

Rabbit Polyclonal CUEDC2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CUEDC2.

View Alternative Names

C10orf66, HOYS6, CUEDC2, CUE domain-containing protein 2

1 Images
Western blot - Anti-CUEDC2 antibody (AB79036)
  • WB

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Western blot - Anti-CUEDC2 antibody (AB79036)

Lane 1:

Western blot - Anti-CUEDC2 antibody (ab79036) at 1 µg/mL

Lane 2:

Western blot - Anti-CUEDC2 antibody (ab79036) at 2 µg/mL

All lanes:

HeLa cell lysate at 15 µg

Predicted band size: 32 kDa

Observed band size: 33 kDa,50 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human CUEDC2. The exact immunogen used to generate this antibody is proprietary information.

Q9H467

Specificity

ab79036 will not cross-react with CUEDC1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab79036 is purified by affinity chromatography via a peptide column
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CUEDC2 also known as CUE domain-containing 2 is an intracellular protein with a molecular mass of approximately 45 kDa. It has a CUE domain which often associates with ubiquitin-binding. This protein is widely expressed in various tissues notably in the liver placenta and kidney. As a component of cellular machinery CUEDC2 plays a significant role in modulating cellular functions.
Biological function summary

The functions of CUEDC2 touch on several cellular processes including inflammation and cell cycle regulation. The protein can modulate signal transduction pathways by influencing transcription factors. It interacts with the anaphase-promoting complex/cyclosome (APC/C) controlling the ubiquitination and degradation of cell cycle proteins. CUEDC2 through these interactions influences the maintenance of cell cycle checkpoints and contributes to the controlled progression of cells through different stages of the cell cycle.

Pathways

CUEDC2 is integral to the NF-kappaB signaling pathway which is a critical mediator of inflammatory responses. CUEDC2 also participates in the c-Jun N-terminal kinase (JNK) pathway. In these contexts CUEDC2 interacts with proteins such as IKK and JNK to regulate the activation and suppression of downstream targets. These interactions highlight its role in maintaining cellular homeostasis and responding to external stimuli.

Researchers associate CUEDC2 with cancer and inflammatory diseases. In cancer the protein modulates pathways critical for tumor growth and invasion suggesting a possible role in tumorigenesis. CUEDC2's interactions with proteins like IKK and components of the APC/C link it to disorders characterized by aberrant cell proliferation and survival. This makes CUEDC2 a potential therapeutic target in developing treatments for related pathological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
See full target information CUEDC2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of clinical medicine 12: PubMed36614872

2022

Renal Tissue Expression of BAFF and BAFF Receptors Is Associated with Proliferative Lupus Nephritis.

Applications

Unspecified application

Species

Unspecified reactive species

Miguel Marín-Rosales,Claudia Azucena Palafox-Sánchez,Ramón Antonio Franco-Topete,Francisco Josué Carrillo-Ballesteros,Alvaro Cruz,Diana Celeste Salazar-Camarena,José Francisco Muñoz-Valle,Francisco Ramos-Solano

Cell death & disease 11:344 PubMed32393737

2020

CUEDC2 controls osteoblast differentiation and bone formation via SOCS3-STAT3 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jung-Woo Kim,Sin-Hye Oh,Mi Nam Lee,Ju Han Song,Byung-Chul Jeong,Jin-Woo Yang,Xianyu Piao,Yaran Zang,Je-Hwang Ryu,Jeong-Tae Koh
View all publications
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Product promise

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