Anti-Cullin 7/CUL-7 antibody

Target data

Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed : 12481031, PubMed : 12904573, PubMed : 21572988, PubMed : 21737058, PubMed : 24793695, PubMed : 35982156). Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity (PubMed : 21572988, PubMed : 21737058, PubMed : 24793695). It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed : 24793695). The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed : 16547496, PubMed : 17332328, PubMed : 35982156). However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1 (PubMed : 35982156). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed : 24793696). The Cul7-RING(FBXW8) complex also mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed : 21572988, PubMed : 24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed : 21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner : the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed : 18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1 : recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed : 24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed : 20139075). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may have additional functions. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation.