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AB89324

Anti-CXCL1/2/3 (pan GRO) antibody [MM0214-11B27]

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(2 Publications)

Mouse Monoclonal CXCL1/GRO alpha antibody. Carrier free. Suitable for WB, FuncS (Neut/Block) and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CXCL3.

View Alternative Names

GRO, GRO1, GROA, MGSA, SCYB1, CXCL1, Growth-regulated alpha protein, C-X-C motif chemokine 1, GRO-alpha(1-73), Melanoma growth stimulatory activity, Neutrophil-activating protein 3, NAP-3

1 Images
Western blot - Anti-CXCL1/2/3 (pan GRO) antibody [MM0214-11B27] (AB89324)
  • WB

Supplier Data

Western blot - Anti-CXCL1/2/3 (pan GRO) antibody [MM0214-11B27] (AB89324)

All lanes:

Western blot - Anti-CXCL1/2/3 (pan GRO) antibody [MM0214-11B27] (ab89324) at 1/500 dilution

All lanes:

Human placenta tissue lysate

Predicted band size: 11 kDa

Observed band size: 8 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0214-11B27

Isotype

IgG1

Carrier free

Yes

Reacts with

Human

Applications

FuncS (Neut/Block), WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CXCL3.

P19876

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "FuncSNeutBlock" : {"fullname" : "Functional Studies (Neut/Block)", "shortname":"FuncS (Neut/Block)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXCL1 also known as GRO alpha CXCL2 and GRO gamma refers to chemokines that are important in immune response. These chemokines are small proteins with a mass of about 8 kDa. They signal through the activation of the chemokine receptor CXCR2. CXCL1/GRO alpha CXCL2 and GRO gamma express in various tissues including epithelial cells and immune cells like neutrophils. They function by recruiting these immune cells to sites of inflammation or injury.
Biological function summary

CXCL1/GRO alpha CXCL2 and GRO gamma are involved in the recruitment and activation of neutrophils. Neutrophils are the first responders in the immune response. These chemokines play a role in angiogenesis and wound healing by stimulating the migration and proliferation of endothelial cells. They do not function as part of a larger protein complex but operate independently in signaling pathways. Their chemotactic activities are essential for proper immune surveillance and response to infections.

Pathways

These chemokines are integral to the NF-kB signaling pathway and MAPK pathway. Through these pathways they mediate inflammatory responses and cellular proliferation. CXCL1/GRO alpha and its family members interact with proteins such as CXCR2 and MAPK which help relay signals for gene expression related to inflammation and cell survival. Their interaction with these pathways highlights their role in initiating and modulating inflammatory processes.

CXCL1/GRO alpha CXCL2 and GRO gamma have associations with inflammatory diseases like rheumatoid arthritis and cancer especially melanoma. In rheumatoid arthritis these chemokines contribute to the recruitment of neutrophils and other immune cells to the joints leading to chronic inflammation. In cancer particularly melanoma they can promote tumor growth by enhancing angiogenesis and suppressing immune response due to the involvement of CXCR2 signaling. Understanding these chemokines involves examining proteins like CXCR2 which play a direct role in disease progression through these inflammatory and cancer pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.
See full target information CXCL1

Additional targets

CXCL2,CXCL3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cancer immunology research 8:1193-1205 PubMed32661094

2020

Chemotherapeutic Tumor Microparticles Elicit a Neutrophil Response Targeting Malignant Pleural Effusions.

Applications

Unspecified application

Species

Unspecified reactive species

Pingwei Xu,Ke Tang,Jingwei Ma,Huafeng Zhang,Dianheng Wang,Liyan Zhu,Jie Chen,Keke Wei,Jincheng Liu,Haiqing Fang,Liang Tang,Yi Zhang,Jing Xie,Yuying Liu,Rui Meng,Li Liu,Xiaorong Dong,Kunyu Yang,Gang Wu,Fei Ma,Bo Huang

PloS one 14:e0213890 PubMed30883593

2019

Endothelial cells are a source of Nestin expression in Pulmonary Arterial Hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Aneel R Bhagwani,Schuyler Hultman,Daniela Farkas,Rebecca Moncayo,Kaivalya Dandamudi,Arsema K Zadu,Carlyne D Cool,Laszlo Farkas
View all publications
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