AB9955

Anti-CXCL11 antibody

Name: Anti-CXCL11 antibody (ab9955) | Abcam
Brand: Abcam Limited
SKU: AB9955
Price: 545 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(17 Publications)

Rabbit Polyclonal CXCL11 antibody. Suitable for WB and reacts with Human samples. Cited in 17 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CXCL11.

View Alternative Names

ITAC, SCYB11, SCYB9B, CXCL11, C-X-C motif chemokine 11, Beta-R1, H174, Interferon gamma-inducible protein 9, Interferon-inducible T-cell alpha chemoattractant, Small-inducible cytokine B11, IP-9, I-TAC

1 Images

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Western blot - Anti-CXCL11 antibody (AB9955)

All lanes:

Western blot - Anti-CXCL11 antibody (ab9955) at 1 µg/mL

All lanes:

Human liver tissue lysate - total protein (<a href='/en-us/products/unavailable/human-liver-tissue-lysate-total-protein-ab29889'>ab29889</a>) at 10 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-preadsorbed-ab97080'>ab97080</a>) at 1/5000 dilution

Predicted band size: 10 kDa

Observed band size: 14 kDa,31 kDa,45 kDa,49 kDa

true

Exposure time: 30s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CXCL11.

O14625

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>To detect CXCL11 by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 μg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hI-TAC is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.</p>" } } }

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Product details

Although some customers have been successful in IHC we no longer batch test in this application.

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Properties and storage information

Form

Lyophilized

Reconstitution

Reconstitute with 200µl of sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.

Purification technique

Affinity purification Immunogen

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXCL11 also known as I-TAC or Interferon-inducible T-cell alpha chemoattractant is a small cytokine belonging to the CXC chemokine family. It weighs around 8 to 11 kilodaltons. CXCL11 predominantly expresses itself in tissues such as the thymus spleen and peripheral blood leukocytes after stimulation with interferons. Its primary role is attracting activated T-cells especially those expressing CXCR3 receptor contributing to immune surveillance and response.

Biological function summary

The chemokine plays an important role in immune system regulation and inflammation response. It attracts and activates leukocytes including T-cells and natural killer cells driving them to sites of inflammation and injury. CXCL11 is not part of a complex but interacts with other chemokines and cytokines to modulate immune responses. Its expression is upregulated in response to IFN-γ working synergistically with other chemokines like CXCL9 and CXCL10 in inflammatory environments.

Pathways

CXCL11 is integral to the chemotaxis signaling pathway. It influences the migration and activation of immune cells by interacting with the CXCR3 receptor. This pathway shares involvement with proteins such as CXCL10 which also binds to CXCR3 enabling precise directionality and regulation of immune cell movement towards inflammation sites. Additionally CXCL11's participation in the inflammatory response pathway connects it to multiple cellular responses necessary for combating infections.

CXCL11 has been linked to autoimmune diseases and cancer. Its elevated expression is associated with conditions like multiple sclerosis where it may contribute to the pathological migration of immune cells into the central nervous system. In cancer CXCL11 can affect tumor microenvironments by recruiting immune cells with cytotoxic potential although this may also facilitate tumor progression in certain contexts. Proteins related to its disease association include CXCR3 and CXCL10 which together modulate various immunological outcomes in these diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

See full target information CXCL11

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Publications (17)

Recent publications for all applications. Explore the full list and refine your search

Arthritis research & therapy 24:49 PubMed35172901

2022

A comprehensive profile of chemokines in the peripheral blood and vascular tissue of patients with Takayasu arteritis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiufang Kong,Sifan Wu,Xiaojuan Dai,Wensu Yu,Jinghua Wang,Ying Sun,Zongfei Ji,Lingying Ma,Xiaomin Dai,Huiyong Chen,Lili Ma,Lindi Jiang

Nature immunology 22:1107-1117 PubMed34385713

2021

Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity.

Applications

Unspecified application

Species

Unspecified reactive species

Pengchong Li,Mengdi Jiang,Ketian Li,Hao Li,Yangzhong Zhou,Xinyue Xiao,Yue Xu,Suzanne Krishfield,Peter E Lipsky,George C Tsokos,Xuan Zhang

British journal of cancer 125:390-401 PubMed34088989

2021

The role of anlotinib-mediated EGFR blockade in a positive feedback loop of CXCL11-EGF-EGFR signalling in anaplastic thyroid cancer angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Juyong Liang,Zhijian Jin,Jie Kuang,Haoran Feng,Qiwu Zhao,Zheyu Yang,Ling Zhan,Baiyong Shen,Jiqi Yan,Wei Cai,Xi Cheng,Weihua Qiu

Cancer management and research 13:3651-3661 PubMed33981164

2021

Elevated RBP-Jκ and CXCL11 Expression in Colon Cancer is Associated with an Unfavorable Clinical Outcome.

Applications

Unspecified application

Species

Unspecified reactive species

Meng-Jie Liu,Hui Guo,Li-Li Jiang,Min Jiao,Shu-Hong Wang,Tao Tian,Xiao Fu,Wen-Juan Wang

Journal of neuroinflammation 18:48 PubMed33602238

2021

Transcriptome profiling of long noncoding RNAs and mRNAs in spinal cord of a rat model of paclitaxel-induced peripheral neuropathy identifies potential mechanisms mediating neuroinflammation and pain.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Li,Chengyu Yin,Boyu Liu,Huimin Nie,Jie Wang,Danyi Zeng,Ruixiang Chen,Xiaofen He,Junfan Fang,Junying Du,Yi Liang,Yongliang Jiang,Jianqiao Fang,Boyi Liu

Experimental & molecular medicine 53:223-234 PubMed33547412

2021

Practical prediction model of the clinical response to programmed death-ligand 1 inhibitors in advanced gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Myung-Giun Noh,Youngmin Yoon,Gihyeon Kim,Hyun Kim,Eulgi Lee,Yeongmin Kim,Changho Park,Kyung-Hwa Lee,Hansoo Park

Cancer management and research 13:133-145 PubMed33469358

2021

miR-1298-5p Influences the Malignancy Phenotypes of Breast Cancer Cells by Inhibiting .

Applications

Unspecified application

Species

Unspecified reactive species

Jie Zhang,Dawei Hu

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:2002497 PubMed33643790

2021

Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Won Choi,Young Hwa Kim,Seung Yeop Oh,Kwang Wook Suh,Young-Sam Kim,Ga-Yeon Lee,Jung Eun Yoon,Soon Sang Park,Young-Kyoung Lee,Yoo Jung Park,Hong Seok Kim,So Hyun Park,Jang-Hee Kim,Tae Jun Park

Annals of palliative medicine 9:2079-2089 PubMed32692224

2020

The protective effect of vitexinin septic encephalopathy by reducing leukocyte-endothelial adhesion and inflammatory response.

Applications

Unspecified application

Species

Unspecified reactive species

Haiquan Cao,Xiaojuan Wang,Bing Zhang,Meiping Ren

Molecular medicine reports 21:2522-2532 PubMed32323817

2020

CCL11 increases the proportion of CD4+CD25+Foxp3+ Treg cells and the production of IL‑2 and TGF‑β by CD4+ T cells via the STAT5 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Rong Wang,Keliang Huang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CXCL11 antibody

Western blot - Anti-CXCL11 antibody (AB9955)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Primary Antibodies

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Reconstitution

Purification technique

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (17)

Product promise