AB190662

Anti-CXCL13 antibody

Name: Anti-CXCL13 antibody (ab190662) | Abcam
Brand: Abcam Limited
SKU: AB190662
Price: 535 USD
Availability: InStock

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(4 Publications)

Rabbit Polyclonal BCA1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human CXCL13 aa 1-100.

View Alternative Names

BCA1, BLC, SCYB13, CXCL13, C-X-C motif chemokine 13, Angie, B cell-attracting chemokine 1, B lymphocyte chemoattractant, CXC chemokine BLC, Small-inducible cytokine B13, BCA-1

1 Images

Supplier Data

Western blot - Anti-CXCL13 antibody (AB190662)

All lanes:

Western blot - Anti-CXCL13 antibody (ab190662) at 1/500 dilution

All lanes:

mouse spleen cells extract at 30 µg

Predicted band size: 13 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

applications

Immunogen

Synthetic Peptide within Human CXCL13 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

O43927

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXCL13 also known as B cell-attracting chemokine 1 (BCA-1) is a chemokine with a molecular weight of approximately 11 kDa. This protein plays an important mechanical role in the immune system by guiding the movement of B cells via chemotaxis. CXCL13 expression occurs mainly in secondary lymphoid tissues such as the spleen lymph nodes and mucosa-associated lymphoid tissue. Its expression is also noted in certain non-lymphoid tissues under inflammatory conditions.

Biological function summary

In the context of immune response and lymphoid tissue organization CXCL13 attracts B cells by interacting with the chemokine receptor CXCR5. These interactions support the formation of B-cell follicles essential for efficient immune responses. CXCL13 is not known to be part of a larger protein complex but instead works through its specific receptor-ligand interactions. Its role in guiding cell migration is vital for the development of secondary lymphoid structures.

Pathways

CXCL13 is significantly involved in the B-cell receptor signaling pathway. The chemokine facilitates the homing of B cells to follicles an important step in the adaptive immune response. CXCL13 closely associates with CXCR5 its specific receptor playing a part in establishing the spatial organization of lymphoid tissues. Additionally the chemokine influences the germinal center reaction an integral part of the immune pathway for antibody maturation.

CXCL13 levels have been linked to autoimmune diseases like rheumatoid arthritis and certain types of lymphomas. In rheumatoid arthritis increased CXCL13 expression correlates with disease severity related to its role in recruiting B cells that contribute to chronic inflammation. In lymphomas particularly those involving B cells CXCL13 supports the growth and survival of malignant cells. Its association with disease states often involves changes in CXCR5 expression or function contributing to disrupted B-cell localization and abnormal immune responses.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.

See full target information CXCL13

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

The Journal of pharmacology and experimental therapeutics : PubMed38955493

2024

Applications

Unspecified application

Species

Unspecified reactive species

Ingrid L Peterson,Natalie E Scholpa,Kiara J Bachtle,Jennifer B Frye,Sanna H Loppi,Austin D Thompson,Kristian Doyle,Tally Marie Largent-Milnes,Rick G Schnellmann

Virology journal 20:128 PubMed37337294

2023

Comparative characterization of Crimean-Congo hemorrhagic fever virus cell culture systems with application to propagation and titration methods.

Applications

Unspecified application

Species

Unspecified reactive species

Hongzhao Li,Greg Smith,Melissa Goolia,Peter Marszal,Bradley S Pickering

Cell biology international 46:1510-1518 PubMed35670241

2022

Activated microglia promote invasion and barrier dysfunction of brain endothelial cells via regulating the CXCL13/CXCR5 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Qiaolei Zhang,Jinhong Jiang,Yonghua Liu,Guangli Ma,Xiaoqiu Wang,Bingmu Fang

American journal of physiology. Cell physiology 316:C70-C80 PubMed30404560

2018

Micro-RNA-143 inhibits proliferation and promotes apoptosis of thymocytes by targeting CXCL13 in a myasthenia gravis mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Dong-Mei Wu,Xin Wen,Xin-Rui Han,Shan Wang,Yong-Jian Wang,Min Shen,Shao-Hua Fan,Juan Zhuang,Zi-Feng Zhang,Qun Shan,Meng-Qiu Li,Bin Hu,Chun-Hui Sun,Jun Lu,Yuan-Lin Zheng

View all publications

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