AB137541

Anti-CXCL14 antibody

Name: Anti-CXCL14 antibody (ab137541) | Abcam
Brand: Abcam Limited
SKU: AB137541
Price: 450 USD
Availability: InStock
Rating: 5 (1 reviews)

(1 Review)

(11 Publications)

Anti-CXCL14 antibody (ab137541) is a rabbit polyclonal antibody detecting CXCL14 in Western Blot, IHC-P. Suitable for Human, Mouse.

View Alternative Names

MIP2G, NJAC, SCYB14, PSEC0212, UNQ240/PRO273, CXCL14, C-X-C motif chemokine 14, Chemokine BRAK, MIP-2G, Small-inducible cytokine B14

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL14 antibody (AB137541)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL14 antibody (AB137541)

Immunohistochemical analysis of paraffin-embedded Human renal cell carcinoma tissue labelling CXCL14 with ab137541 at 1/100 dilution.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL14 antibody (AB137541)

Immunohistochemical analysis of paraffin-embedded Human renal cell carcinoma tissue labelling CXCL14 with ab137541 at 1/100 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human CXCL14 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O95715

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Reactivity data

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Product details

What is this antibody validated in?
Anti-CXCL14 antibody (ab137541) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human, Mouse samples.

What is the molecular weight of CXCL14?
Anti-CXCL14 (ab137541) specifically detects a band for CXCL14 (UniProt: O95715) at a molecular weight of 13kDa.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CXCL14 protein also known as BRAK is a small cytokine belonging to the CXC chemokine family. It has a molecular mass of 8.9 kDa and is expressed in various tissues with high levels in the kidney lung skin and reproductive tissues. It does not normally circulate in the blood but rather acts in tissues. The protein plays a role in immune system regulation by being involved in the migration of immune cells.

Biological function summary

CXCL14 influences cell signaling pathways that regulate immune responses and tissue homeostasis. It engages in the attraction of immune cells like monocytes and dendritic cells to specific tissues. While CXCL14 is not part of a larger complex its function in modulating local immune environments is significant. This protein’s role in immune surveillance contributes to both normal physiological conditions and response to pathology.

Pathways

Interactions of CXCL14 involve key signaling cascades. The protein is part of pathways that regulate inflammation and cell movement including the MAPK and PI3K signaling pathways. Related proteins such as CXCR4 and CCR2 interact within these pathways to coordinate cell signaling and chemotaxis. These interactions facilitate communication between cells and regulate responses essential for maintaining tissue integrity.

CXCL14 links with conditions like cancer and obesity. Studies suggest that CXCL14 may play a dual role in cancer acting as a tumor suppressor in certain contexts by influencing immune cell infiltration into tumors. In obesity altered expression patterns of CXCL14 have been observed highlighting potential roles in adipose tissue regulation. Proteins like CXCR4 are also connected with CXCL14 in these disease contexts suggesting complex interdependencies within the cellular communication network.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.

See full target information CXCL14

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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 39:e70591 PubMed40392027

2025

CXCL14 Chemokine Exacerbates Acute Viral Hepatitis in Coronavirus MHV-Infected Mice and Is Associated With Human Acute Viral Hepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Christelle Devisme,Claire Piquet-Pellorce,Arnaud Chalin,Benjamin Lefevre,Charlotte Pronier,Vincent Thibault,Jacques Le Seyec,Céline Raguénès-Nicol,Charaf Benarafa,Michel Samson

American journal of translational research 17:1251-1264 PubMed40092086

2025

CXCL14 regulates ovarian endometriosis progression by targeting PCNA.

Applications

Unspecified application

Species

Unspecified reactive species

Meng Liu,Yan Zhang,Yayun Zhang,Ting Fu,Xiaoxue Xi,Shunyu Hou

Cancer immunology, immunotherapy : CII 74:47 PubMed39751958

2025

Distinct immune signatures for predicting the immunotherapy efficacy of esophageal squamous cell carcinoma or adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Wu,Guohui Qin,Jinyan Liu,Qitai Zhao,Xueke Zhao,Xin Song,Lidong Wang,Shengli Yang,Yi Zhang

Molecular neurodegeneration 18:31 PubMed37143090

2023

BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides.

Applications

Unspecified application

Species

Unspecified reactive species

John Zhou,Neeraj Singh,James Galske,Jacob Hudobenko,Xiangyou Hu,Riqiang Yan

Frontiers in oncology 12:833866 PubMed35769715

2022

Plasma CXCL14 as a Candidate Biomarker for the Diagnosis of Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Peng-Fei Tian,Yu-Chen Ma,Dong-Sheng Yue,Fan Liang,Chen-Guang Li,Chen Chen,Hua Zhang,Xiao-Yan Sun,Wu-Hao Huang,Zhen-Fa Zhang,Guang-Biao Zhou,Gui-Zhen Wang,Bin Zhang,Chang-Li Wang

Journal of cellular and molecular medicine 25:4596-4607 PubMed33733587

2021

CDX2 enhances natural killer cell-mediated immunotherapy against head and neck squamous cell carcinoma through up-regulating CXCL14.

Applications

Unspecified application

Species

Unspecified reactive species

Haitao Wang,Shanji Nan,Ying Wang,Chengbi Xu

Scientific reports 10:13939 PubMed32883960

2020

Multi-omic single cell analysis resolves novel stromal cell populations in healthy and diseased human tendon.

Applications

Unspecified application

Species

Unspecified reactive species

Adrian R Kendal,Thomas Layton,Hussein Al-Mossawi,Louise Appleton,Stephanie Dakin,Rick Brown,Constantinos Loizou,Mark Rogers,Robert Sharp,Andrew Carr

Mediators of inflammation 2020:2431705 PubMed32317861

2020

CXCL14 Overexpression Attenuates Sepsis-Associated Acute Kidney Injury by Inhibiting Proinflammatory Cytokine Production.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Lv,Zhi-Lin Wu,Zheng Gan,Ping Gui,Shang-Long Yao

Experimental and therapeutic medicine 18:2385-2392 PubMed31555349

2019

Dexamethasone combined with berberine is an effective therapy for bleomycin-induced pulmonary fibrosis in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Li Li,Qiuhong Li,Lei Wei,Zhongfu Wang,Wei Ma,Fangying Liu,Yanhua Shen,Shanfang Zhang,Xiulian Zhang,Huiping Li,Yechang Qian

Journal of cellular biochemistry 120:13372-13381 PubMed30920024

2019

Chemokine (C-X-C motif) ligand 14 contributes to lipopolysaccharide-induced fibrogenesis in mouse L929 fibroblasts via modulating PPM1A.

Applications

Unspecified application

Species

Unspecified reactive species

Li Li,Qiuhong Li,Lei Wei,Zhongfu Wang,Wei Ma,Fangying Liu,Yanhua Shen,Shanfang Zhang,Xiulian Zhang,Huiping Li,Yechang Qian

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CXCL14 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL14 antibody (AB137541)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL14 antibody (AB137541)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (11)

Product promise