Rabbit Polyclonal CXCL14 antibody. Suitable for ELISA, WB, sELISA, IHC-P, ICC/IF and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CXCL14.
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- PloS one 18:e02817982023A three protein signature fails to externally validate as a biomarker to predict surgical outcome in high-grade epithelial ovarian cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAmy Hawarden,Marcus Price,Bryn Russell,Godfrey Wilson,Laura Farrelly,Andrew Embleton-Thirsk,Mahesh Parmar,Richard EdmondsonPubMed 36952534
- Oncogenesis 10:662021Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKun Xu,Runtian Wang,Hui Xie,Longfei Hu,Cong Wang,Jiali Xu,Chengjun Zhu,Yiqiu Liu,Fangyan Gao,Xintong Li,Cenzhu Wang,Jinyi Huang,Wenbin Zhou,Guohua Zhou,Yongqian Shu,Xiaoxiang GuanPubMed 34611125
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34:11257-112712020Two coupled mutations abolished the binding of CEBPB to the promoter of CXCL14 that displayed an antiviral effect on PRRSV by activating IFN signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLizhu Niu,Zhiwei Zheng,Qianjing Xue,Huijun Cheng,Ying Liu,Huanling Wang,Xueying Hu,Anding Zhang,Bang Liu,Xuewen XuPubMed 32648265
- Cancer science 111:2588-25972020High expression of CXCL14 is a biomarker of lung adenocarcinoma with micropapillary pattern.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuki Sata et. al.PubMed 32403160
- The Journal of clinical investigation 128:5235-52502018HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYingying Wang et. al.PubMed 30204129
- Medicine 97:e01012018CXCL14 and NOS1 expression in specimens from patients with stage I-IIIA nonsmall cell lung cancer after curative resection.Applications:IHCReactive species:HumanXiaoqin Ji,Zetian Shen,Benxin Zhao,Xi Yuan,Xixu ZhuPubMed 29517684
- Oncotarget 7:14207-192016Transcriptomic analysis of stage 1 versus advanced adult granulosa cell tumors.Applications:IHCReactive species:Unspecified reactive speciesMaria Alexiadis,Simon Chu,Dilys Leung,Jodee A Gould,Tom Jobling,Peter J FullerPubMed 26893359
- Journal of the National Cancer Institute 106:2014Risk prediction for late-stage ovarian cancer by meta-analysis of 1525 patient samples.
- Cancer science 104:1523-312013Antitumor efficacy of C-X-C motif chemokine ligand 14 in hepatocellular carcinoma in vitro and in vivo.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWeilin Wang et. al.PubMed 24033560
- Breast cancer research and treatment 135:725-352012Expression of CXCL14 and its anticancer role in breast cancer.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
- Standard buffer
- Form
- Lyophilized
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human CXCL14. Database link O95715
Reactivity data
Select an application| ELISA | WB | sELISA | IHC-P | ICC/IF | |
|---|---|---|---|---|---|
| Human | Expected | Expected | Tested | Expected | Expected |
ELISA
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes Detection limit 0.2 - 0.4 ng/well. |
WB
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes Detection limit 1.5 - 3.0 ng/lane under reducing or non-reducing conditions. |
sELISA
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes To detect CXCL14 by sandwich ELISA (using 100 μl/well antibody solution) a concentration of 0.5 - 2.0 μg/ml of this antibody is required. |
IHC-P
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
ICC/IF
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
Associated Products
Select an associated product type
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Target data
Function
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.
Alternative names
MIP2G, NJAC, SCYB14, PSEC0212, UNQ240/PRO273, CXCL14, C-X-C motif chemokine 14, Chemokine BRAK, MIP-2G, Small-inducible cytokine B14
Recommended products
Rabbit Polyclonal CXCL14 antibody. Suitable for ELISA, WB, sELISA, IHC-P, ICC/IF and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CXCL14.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
- Standard buffer
- Form
- Lyophilized
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human CXCL14. Database link O95715
- Purification technique
- Affinity purification Protein A
- Reconstitution
- Reconstitute 100µl sterile water to give a concentration 1 mg/ml. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
Notes
Although some customers have been successful in IHC we no longer batch test in this application.The sterile filtered antibody solution was lyophilized from 0.5xPBS, pH7.4.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The CXCL14 protein also known as BRAK is a small cytokine belonging to the CXC chemokine family. It has a molecular mass of 8.9 kDa and is expressed in various tissues with high levels in the kidney lung skin and reproductive tissues. It does not normally circulate in the blood but rather acts in tissues. The protein plays a role in immune system regulation by being involved in the migration of immune cells.
- Biological function summary
CXCL14 influences cell signaling pathways that regulate immune responses and tissue homeostasis. It engages in the attraction of immune cells like monocytes and dendritic cells to specific tissues. While CXCL14 is not part of a larger complex its function in modulating local immune environments is significant. This protein’s role in immune surveillance contributes to both normal physiological conditions and response to pathology.
- Pathways
Interactions of CXCL14 involve key signaling cascades. The protein is part of pathways that regulate inflammation and cell movement including the MAPK and PI3K signaling pathways. Related proteins such as CXCR4 and CCR2 interact within these pathways to coordinate cell signaling and chemotaxis. These interactions facilitate communication between cells and regulate responses essential for maintaining tissue integrity.
- Associated diseases and disorders
CXCL14 links with conditions like cancer and obesity. Studies suggest that CXCL14 may play a dual role in cancer acting as a tumor suppressor in certain contexts by influencing immune cell infiltration into tumors. In obesity altered expression patterns of CXCL14 have been observed highlighting potential roles in adipose tissue regulation. Proteins like CXCR4 are also connected with CXCL14 in these disease contexts suggesting complex interdependencies within the cellular communication network.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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Sandwich ELISA - Anti-CXCL14 antibody (ab46010)
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