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AB316784

Anti-CXCL17/DMC antibody [EPR22655-87] - BSA and Azide free (Detector)

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Rabbit Recombinant Monoclonal CXCL17/DMC antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

View Alternative Names

VCC1, UNQ473/PRO842, CXCL17, C-X-C motif chemokine 17, 6-Cys CXCL17, Dendritic cell and monocyte chemokine-like protein, VEGF coregulated chemokine 1, DMC

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Sandwich ELISA - Anti-CXCL17/DMC antibody [EPR22655-87] - BSA and Azide free (Detector) (AB316784)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-CXCL17/DMC antibody [EPR22655-87] - BSA and Azide free (Detector) (AB316784)

Sandwich ELISA of ab316782 with the capture antibody ab316783 dilution at 2 ug/mL and detector antibody ab316784 dilution at 0.5 ug/mL.

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR22655-87

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

ab316784 is a BSA and Azide free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human CXCL17/DMC. The recommended pair for sandwich ELISA is:

Capture: ab316783, Human CXCL17/DMC Capture Antibody (unconjugated)

Detector: ab316784, Human CXCL17/DMC Detector Antibody (unconjugated)

The reference range value is 19.53-1250 pg/mL.

The recommended antibody orientation is based on internal optimization for ELISAbased assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency. The antibodies are provided at an approximate concentration of 1 mg/ml as measured by the protein A280 method. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Constituents: 100% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXCL17 also known as DMC is a chemokine involved in immune cell recruitment. This protein has a molecular mass of about 17 kDa. Researchers found CXCL17 expressed in epithelial tissues including the respiratory tract and gastrointestinal tract. Its expression pattern indicates a role in mucosal immunity where it may attract immune cells to sites requiring defense against pathogens.
Biological function summary

CXCL17 functions to recruit monocytes and dendritic cells to regions where they are needed. It does not appear to form part of a larger protein complex. Its ability to attract specific immune cells suggests it has an important role in organizing immune responses particularly in tissues constantly exposed to external environmental factors. Additionally its presence in mucosal tissues supports the hypothesis that it might participate in the first line of defense against environmental pathogens.

Pathways

CXCL17 fits within the broader chemokine signaling pathways promoting cell migration and adhesion. This signaling integrates with inflammatory pathways such as the NF-kB pathway which regulates the expression of various other chemokines and cytokines. Researchers have noted relationships between CXCL17 and other chemokines like CXCL12 and CXCL8 indicating potential synergistic or regulatory interactions in immune response modulations.

CXCL17 associates with conditions like chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). These connections suggest a role for CXCL17 in chronic inflammatory and fibrotic pathologies of the lungs. In the context of these diseases the protein interacts with inflammatory mediators such as IL-6 contributing to the persistence and exacerbation of inflammation observed in these conditions. Understanding CXCL17's involvement in these diseases might aid in developing targeted therapies to modulate immune function and inflammation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells (PubMed : 16455961, PubMed : 23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed : 16989774, PubMed : 23115081). Acts as an anti-inflammatory in the stomach (PubMed : 23115081). May play a role in the innate defense against infections (PubMed : 17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed : 25411203).. 4-Cys CXCL17. Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
See full target information CXCL17
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Complementary Products

Assay Kits

AB316782

Human CXCL17/DMC Antibody Pair - BSA and Azide free

RabMAb|Recombinant

Sandwich ELISA - Human CXCL17/DMC Antibody Pair - BSA and Azide free (AB316782)

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Product promise

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