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AB91511

Anti-CXCL2 antibody

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(7 Publications)

Goat Polyclonal CXCL2 antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human CXCL2 aa 50 to C-terminus.

View Alternative Names

GRO2, GROB, MIP2A, SCYB2, CXCL2, C-X-C motif chemokine 2, Growth-regulated protein beta, Macrophage inflammatory protein 2-alpha, Gro-beta, MIP2-alpha

2 Images
Western blot - Anti-CXCL2 antibody (AB91511)
  • WB

Unknown

Western blot - Anti-CXCL2 antibody (AB91511)

ab91511 (0.03µg/ml) staining of Daudi lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence

All lanes:

Western blot - Anti-CXCL2 antibody (ab91511)

Predicted band size: 11 kDa

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Western blot - Anti-CXCL2 antibody (AB91511)
  • WB

Unknown

Western blot - Anti-CXCL2 antibody (AB91511)

All lanes:

Western blot - Anti-CXCL2 antibody (ab91511) at 0.2 µg/mL

All lanes:

Human duodenum lysate at 35 µg

Predicted band size: 11 kDa

Observed band size: 17 kDa

true

Exposure time: 1hr

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human CXCL2 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P19875

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.03-0.1 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab91511 was purified from goat serum by ammonium sulphate precipitation, followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 0.5% BSA, 0.5% Tris buffered saline
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CXCL2 protein also known as macrophage inflammatory protein 2 (MIP-2) or KC in the mouse model functions as a chemokine. It weighs approximately 7.8 kDa and is part of the CXC chemokine family. CXCL2 is mainly expressed in macrophages neutrophils and certain epithelial cells. It plays an important role in mediating the migration of these cells to sites of inflammation or injury.
Biological function summary

CXCL2 attracts and activates neutrophils as part of the innate immune response. It acts independently not as part of a larger complex to provoke a chemotactic response guiding neutrophils to areas of tissue injury. CXCL2 also promotes the release of other cytokines and enzymes that contribute to inflammation. Its activity is mediated through its interaction with receptors like CXCR2 on target cell surfaces.

Pathways

CXCL2 is involved in inflammatory signaling and leukocyte migration. It holds importance in the chemokine signaling pathway which regulates leukocyte trafficking. CXCL2 interacts with proteins like CXCR2 influencing the inflammation process by activating downstream kinases and other signal transduction molecules such as mitogen-activated protein kinases (MAPKs).

CXCL2 is connected to inflammatory conditions and diseases like sepsis and inflammatory bowel disease (IBD). Elevated levels of CXCL2 can enhance the inflammatory response which is linked to the progression of these conditions. The protein is also associated with tumor necrosis factor-alpha (TNF-alpha) which amplifies inflammation and tissue damage during disease processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.
See full target information CXCL2
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Cell discovery 10:109 PubMed39468013

2024

Targeting a chemo-induced adaptive signaling circuit confers therapeutic vulnerabilities in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yohei Saito,Yi Xiao,Jun Yao,Yunhai Li,Wendao Liu,Arseniy E Yuzhalin,Yueh-Ming Shyu,Hongzhong Li,Xiangliang Yuan,Ping Li,Qingling Zhang,Ziyi Li,Yongkun Wei,Xuedong Yin,Jun Zhao,Seyed M Kariminia,Yao-Chung Wu,Jinyang Wang,Jun Yang,Weiya Xia,Yutong Sun,Eek-Hoon Jho,Paul J Chiao,Rosa F Hwang,Haoqiang Ying,Huamin Wang,Zhongming Zhao,Anirban Maitra,Mien-Chie Hung,Ronald A DePinho,Dihua Yu

NPJ genomic medicine 6:87 PubMed34654834

2021

Single-cell RNA sequencing for the identification of early-stage lung cancer biomarkers from circulating blood.

Applications

Unspecified application

Species

Unspecified reactive species

Jinhong Kim,Zhaolin Xu,Paola A Marignani

The Journal of international medical research 48:300060519896150 PubMed32212883

2020

Characteristics of expression in coronary atherosclerosis and negative regulation by microRNA-421.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Yang,Hu Liu,Qian Cao,Wei Zhong

The Journal of investigative dermatology 139:1171-1181.e6 PubMed30684552

2019

Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2.

Applications

Unspecified application

Species

Unspecified reactive species

Holly N Wilkinson,Christopher Clowes,Kayleigh L Banyard,Paolo Matteuci,Kimberly A Mace,Matthew J Hardman

American journal of translational research 9:155-166 PubMed28123642

2017

Antimetastatic effects of norcantharidin on hepatocellular carcinoma cells by up-regulating FAM46C expression.

Applications

WB

Species

Human

Xu-Ying Wan,Xiao-Feng Zhai,Yi-Ping Jiang,Ting Han,Qiao-Yan Zhang,Hai-Liang Xin

Genes & nutrition 10:482 PubMed26233308

2015

miRNA-regulated gene expression differs in celiac disease patients according to the age of presentation.

Applications

Unspecified application

Species

Unspecified reactive species

Gaia Buoli Comani,Roberto Panceri,Marco Dinelli,Andrea Biondi,Clara Mancuso,Raffaella Meneveri,Donatella Barisani

The American journal of gastroenterology 109:1662-74 PubMed25070052

2014

miRNAs affect the expression of innate and adaptive immunity proteins in celiac disease.

Applications

Unspecified application

Species

Unspecified reactive species

Serena Magni,Gaia Buoli Comani,Luca Elli,Samanta Vanessi,Elisa Ballarini,Gabriella Nicolini,Michela Rusconi,Mirco Castoldi,Raffaella Meneveri,Martina U Muckenthaler,Maria Teresa Bardella,Donatella Barisani
View all publications
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