Goat Polyclonal CXCL2 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human CXCL2 aa 50 to C-terminus.
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Publications
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- NPJ genomic medicine 6:872021Single-cell RNA sequencing for the identification of early-stage lung cancer biomarkers from circulating blood.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJinhong Kim,Zhaolin Xu,Paola A MarignaniPubMed 34654834
- The Journal of international medical research 48:3000605198961502020Characteristics of expression in coronary atherosclerosis and negative regulation by microRNA-421.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJun Yang,Hu Liu,Qian Cao,Wei ZhongPubMed 32212883
- The Journal of investigative dermatology 139:1171-1181.e62019Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHolly N Wilkinson et. al.PubMed 30684552
- American journal of translational research 9:155-1662017Antimetastatic effects of norcantharidin on hepatocellular carcinoma cells by up-regulating FAM46C expression.
- Genes & nutrition 10:4822015miRNA-regulated gene expression differs in celiac disease patients according to the age of presentation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGaia Buoli Comani et. al.PubMed 26233308
- The American journal of gastroenterology 109:1662-742014miRNAs affect the expression of innate and adaptive immunity proteins in celiac disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSerena Magni et. al.PubMed 25070052
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris buffered saline- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human CXCL2 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P19875
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.03000-0.10000 µg/mL | Notes 1 hour primary incubation is recommended for this product. |
Associated Products
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4 products for Alternative Product
Target data
Function
Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.
Alternative names
GRO2, GROB, MIP2A, SCYB2, CXCL2, C-X-C motif chemokine 2, Growth-regulated protein beta, Macrophage inflammatory protein 2-alpha, Gro-beta, MIP2-alpha
Recommended products
Goat Polyclonal CXCL2 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human CXCL2 aa 50 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris buffered saline- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human CXCL2 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P19875
- Purification technique
- Affinity purification Immunogen
- Concentration
- Purification notes
ab91511 was purified from goat serum by ammonium sulphate precipitation, followed by antigen affinity chromatography using the immunizing peptide.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The CXCL2 protein also known as macrophage inflammatory protein 2 (MIP-2) or KC in the mouse model functions as a chemokine. It weighs approximately 7.8 kDa and is part of the CXC chemokine family. CXCL2 is mainly expressed in macrophages neutrophils and certain epithelial cells. It plays an important role in mediating the migration of these cells to sites of inflammation or injury.
- Biological function summary
CXCL2 attracts and activates neutrophils as part of the innate immune response. It acts independently not as part of a larger complex to provoke a chemotactic response guiding neutrophils to areas of tissue injury. CXCL2 also promotes the release of other cytokines and enzymes that contribute to inflammation. Its activity is mediated through its interaction with receptors like CXCR2 on target cell surfaces.
- Pathways
CXCL2 is involved in inflammatory signaling and leukocyte migration. It holds importance in the chemokine signaling pathway which regulates leukocyte trafficking. CXCL2 interacts with proteins like CXCR2 influencing the inflammation process by activating downstream kinases and other signal transduction molecules such as mitogen-activated protein kinases (MAPKs).
- Associated diseases and disorders
CXCL2 is connected to inflammatory conditions and diseases like sepsis and inflammatory bowel disease (IBD). Elevated levels of CXCL2 can enhance the inflammatory response which is linked to the progression of these conditions. The protein is also associated with tumor necrosis factor-alpha (TNF-alpha) which amplifies inflammation and tissue damage during disease processes.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-CXCL2 antibody (ab91511)
All lanes: Western blot - Anti-CXCL2 antibody (ab91511) at 0.2 µg/mL
All lanes: Human duodenum lysate at 35 µg
Developed using the ECL technique.
Predicted band size: 11 kDa
Observed band size: 17 kDa
Exposure time: 1hr
Western blot - Anti-CXCL2 antibody (ab91511)
ab91511 (0.03µg/ml) staining of Daudi lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence
All lanes: Western blot - Anti-CXCL2 antibody (ab91511)
Predicted band size: 11 kDa
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