Rabbit Polyclonal CXCL2 antibody. Suitable for ELISA, WB, sELISA, Nucleotide Array, Neut, IHC-Fr and reacts with Rat samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Cxcl2.
| ELISA | WB | sELISA | Nucleotide Array | Neut | IHC-Fr | |
|---|---|---|---|---|---|---|
| Rat | Expected | Expected | Expected | Expected | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes To detect Rat CXCL2 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of ab9777 is required. This antigen affinity purified antibody, in conjunction with an Anti-Rat CXCL2 as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Rat CXCL2. |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes To yield one-half maximal inhibition [ND50] of the biological activity of rGRO beta/MIP-2 (100 ng/ml), a concentration of 3.0 - 5.0 Âμg/ml of this antibody is required. |
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info Use at an assay dependent concentration. | Notes - |
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Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation.
Cinc3, Mip-2, Mip2, Scyb2, Cxcl2, C-X-C motif chemokine 2, Cytokine-induced neutrophil chemoattractant 3, Macrophage inflammatory protein 2, CINC-3, MIP2
Rabbit Polyclonal CXCL2 antibody. Suitable for ELISA, WB, sELISA, Nucleotide Array, Neut, IHC-Fr and reacts with Rat samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Cxcl2.
Although some customers have been successful in IHC we no longer batch test in this application.
The CXCL2 protein also known as macrophage inflammatory protein 2 (MIP-2) or KC in the mouse model functions as a chemokine. It weighs approximately 7.8 kDa and is part of the CXC chemokine family. CXCL2 is mainly expressed in macrophages neutrophils and certain epithelial cells. It plays an important role in mediating the migration of these cells to sites of inflammation or injury.
CXCL2 attracts and activates neutrophils as part of the innate immune response. It acts independently not as part of a larger complex to provoke a chemotactic response guiding neutrophils to areas of tissue injury. CXCL2 also promotes the release of other cytokines and enzymes that contribute to inflammation. Its activity is mediated through its interaction with receptors like CXCR2 on target cell surfaces.
CXCL2 is involved in inflammatory signaling and leukocyte migration. It holds importance in the chemokine signaling pathway which regulates leukocyte trafficking. CXCL2 interacts with proteins like CXCR2 influencing the inflammation process by activating downstream kinases and other signal transduction molecules such as mitogen-activated protein kinases (MAPKs).
CXCL2 is connected to inflammatory conditions and diseases like sepsis and inflammatory bowel disease (IBD). Elevated levels of CXCL2 can enhance the inflammatory response which is linked to the progression of these conditions. The protein is also associated with tumor necrosis factor-alpha (TNF-alpha) which amplifies inflammation and tissue damage during disease processes.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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