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AB9841

Anti-CXCL2 antibody

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(2 Publications)

Rabbit Polyclonal CXCL2 antibody. Suitable for WB, sELISA and reacts with Recombinant full length protein - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CXCL2.

View Alternative Names

GRO2, GROB, MIP2A, SCYB2, CXCL2, C-X-C motif chemokine 2, Growth-regulated protein beta, Macrophage inflammatory protein 2-alpha, Gro-beta, MIP2-alpha

2 Images
Sandwich ELISA - Anti-CXCL2 antibody (AB9841)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-CXCL2 antibody (AB9841)

To detect human CXCL2 by sandwich ELISA (using 100 μl/well antibody solution) a concentration of 0.5 - 2.0 μg/ml of ab9841 is required. This antigen affinity purified antibody, in conjunction with anti-CXCL2 (Biotin) (ab245843) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant human CXCL2 .

Western blot - Anti-CXCL2 antibody (AB9841)
  • WB

Supplier Data

Western blot - Anti-CXCL2 antibody (AB9841)

To detect human CXCL2 by Western Blot analysis ab9841 can be used at a concentration of 0.1-0.2 μg/ml. When used in conjunction with compatible secondary reagents, the detection limit for recombinant human CXCL2 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Image shown is reducing conditions; Human recombinant CXCL2 protein at 250 - 0.24 ng/ml.

Lane 1 is MW marker, lanes 2-12 human recombinant CXCL2 protein.

All lanes:

Western blot - Anti-CXCL2 antibody (ab9841)

Predicted band size: 11 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Light chain type

unknown

Carrier free

No

Applications

sELISA, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CXCL2.

P19875

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.2 µg/mL", "WB-species-notes": "<p>The detection limit for recombinant human CXCL2 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.</p>", "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "0.5-2 µg/mL", "sELISA-species-notes": "<p>Use 100 μl/well antibody solution. Detects of 0.2 - 0.4 ng/well of recombinant human CXCL2.</p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute with 200µl of sterile water.
Purification technique
Affinity purification Immunogen
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CXCL2 protein also known as macrophage inflammatory protein 2 (MIP-2) or KC in the mouse model functions as a chemokine. It weighs approximately 7.8 kDa and is part of the CXC chemokine family. CXCL2 is mainly expressed in macrophages neutrophils and certain epithelial cells. It plays an important role in mediating the migration of these cells to sites of inflammation or injury.
Biological function summary

CXCL2 attracts and activates neutrophils as part of the innate immune response. It acts independently not as part of a larger complex to provoke a chemotactic response guiding neutrophils to areas of tissue injury. CXCL2 also promotes the release of other cytokines and enzymes that contribute to inflammation. Its activity is mediated through its interaction with receptors like CXCR2 on target cell surfaces.

Pathways

CXCL2 is involved in inflammatory signaling and leukocyte migration. It holds importance in the chemokine signaling pathway which regulates leukocyte trafficking. CXCL2 interacts with proteins like CXCR2 influencing the inflammation process by activating downstream kinases and other signal transduction molecules such as mitogen-activated protein kinases (MAPKs).

CXCL2 is connected to inflammatory conditions and diseases like sepsis and inflammatory bowel disease (IBD). Elevated levels of CXCL2 can enhance the inflammatory response which is linked to the progression of these conditions. The protein is also associated with tumor necrosis factor-alpha (TNF-alpha) which amplifies inflammation and tissue damage during disease processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.
See full target information CXCL2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 26:492 PubMed37854860

2023

MicroRNA‑27a‑3p regulates the proliferation and chemotaxis of pulmonary macrophages in non‑small cell lung carcinoma tissues through CXCL2.

Applications

Unspecified application

Species

Unspecified reactive species

Congying Zhai,Baoliang Liu,Fanggong Kan,Shuhui Zhai,Ronghua Zhang

Microvascular research 68:169-78 PubMed15501236

2004

Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2.

Applications

Unspecified application

Species

Unspecified reactive species

Heike Hall,Jeffrey A Hubbell
View all publications
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Product promise

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