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AB9950

Anti-CXCL2 antibody

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(6 Publications)

Rabbit Polyclonal CXCL2 antibody. Suitable for ELISA, WB, sELISA and reacts with Mouse samples. Cited in 6 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Cxcl2.

View Alternative Names

Mip-2, Mip2, Scyb2, Cxcl2, C-X-C motif chemokine 2, Macrophage inflammatory protein 2, MIP2

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

Unknown

Light chain type

unknown

Carrier free

No

Reacts with

Mouse

Applications

WB, sELISA, ELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Cxcl2.

P10889

Reactivity data

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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute with 200µl of sterile water.
Purification technique
Affinity purification Immunogen
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The CXCL2 protein also known as macrophage inflammatory protein 2 (MIP-2) or KC in the mouse model functions as a chemokine. It weighs approximately 7.8 kDa and is part of the CXC chemokine family. CXCL2 is mainly expressed in macrophages neutrophils and certain epithelial cells. It plays an important role in mediating the migration of these cells to sites of inflammation or injury.
Biological function summary

CXCL2 attracts and activates neutrophils as part of the innate immune response. It acts independently not as part of a larger complex to provoke a chemotactic response guiding neutrophils to areas of tissue injury. CXCL2 also promotes the release of other cytokines and enzymes that contribute to inflammation. Its activity is mediated through its interaction with receptors like CXCR2 on target cell surfaces.

Pathways

CXCL2 is involved in inflammatory signaling and leukocyte migration. It holds importance in the chemokine signaling pathway which regulates leukocyte trafficking. CXCL2 interacts with proteins like CXCR2 influencing the inflammation process by activating downstream kinases and other signal transduction molecules such as mitogen-activated protein kinases (MAPKs).

CXCL2 is connected to inflammatory conditions and diseases like sepsis and inflammatory bowel disease (IBD). Elevated levels of CXCL2 can enhance the inflammatory response which is linked to the progression of these conditions. The protein is also associated with tumor necrosis factor-alpha (TNF-alpha) which amplifies inflammation and tissue damage during disease processes.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst.
See full target information Cxcl2

Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Journal of periodontology 93:1940-1950 PubMed35100435

2022

Macrophage migration inhibitory factor regulates specific innate immune sensor responses in gingival epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Nutthapong Kantrong,Ana M Chang,Shatha Bamashmous,Adeline M Hajjar,Richard J Bucala,Richard P Darveau

Experimental and therapeutic medicine 15:2356-2364 PubMed29456642

2018

Anti-Semaphorin-7A single chain antibody demonstrates beneficial effects on pulmonary inflammation during acute lung injury.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Chen,Hailing Wang,Kui Jia,Hao Wang,Tao Ren

Molecular medicine reports 14:2983-90 PubMed27510583

2016

Toll‑like receptor 4 contributes to acute kidney injury after cardiopulmonary resuscitation in mice.

Applications

Unspecified application

Species

Mouse

Qingsong Zhang,Gang Li,Li Xu,Qian Li,Qianyan Wang,Yue Zhang,Qing Zhang,Peng Sun

Journal of dental research 95:946-52 PubMed27013641

2016

Site-Specific Neutrophil Migration and CXCL2 Expression in Periodontal Tissue.

Applications

Unspecified application

Species

Unspecified reactive species

A Greer,K Irie,A Hashim,B G Leroux,A M Chang,M A Curtis,R P Darveau

Cellular microbiology 15:1419-26 PubMed23433011

2013

Commensal bacteria-dependent select expression of CXCL2 contributes to periodontal tissue homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Camille Zenobia,Xiao Long Luo,Ahmed Hashim,Toshiharu Abe,Lijian Jin,Yucheng Chang,Zhi Chao Jin,Jian Xun Sun,George Hajishengallis,Mike A Curtis,Richard P Darveau

Biochemical and biophysical research communication 424:456-61 PubMed22771802

2012

CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction.

Applications

Neut

Species

Unspecified reactive species

Erika Oue,Ji-Won Lee,Kei Sakamoto,Tadahiro Iimura,Kazuhiro Aoki,Kou Kayamori,Yasuyuki Michi,Masashi Yamashiro,Kiyoshi Harada,Teruo Amagasa,Akira Yamaguchi
View all publications

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