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AB18134

Anti-CXCL5 antibody

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(3 Publications)

Rabbit Polyclonal CXCL5 antibody. Carrier free. Suitable for WB, ELISA and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Cxcl5.

View Alternative Names

Scyb5, Cxcl5, C-X-C motif chemokine 5, Cytokine LIX, Small-inducible cytokine B5

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Mouse

Applications

WB, ELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Cxcl5.

P50228

Specificity

Specific for mouse lipopolysaccharide induced CXC chemokine (LIX).

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Alternative Products

Primary Antibodies

AB9802

Anti-CXCL5 antibody

Sandwich ELISA - Anti-CXCL5 antibody (AB9802)

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Assay Kits

AB264611

Mouse LIX ELISA Kit (CXCL5)

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Sandwich ELISA - Mouse LIX ELISA Kit (CXCL5) (AB264611)

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Proteins & Peptides

AB287930

Recombinant Mouse CXCL5 protein (Active)

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Mass Spectrometry - Recombinant Mouse CXCL5 protein (Active) (AB287930)

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Primary Antibodies

AB7817

Anti-alpha smooth muscle Actin antibody [1A4]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [1A4] (AB7817)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "0.1-0.2 µg/mL", "WB-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "0.5-2 µg/mL", "ELISA-species-notes": "<p>The detection limit is 0.2-0.4ng/well of recombinant mouse LIX</p>" } } }
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Product details

Mouse CXCL5 is the equivalent of human CXCL6 based on genetic and biological evidence as pointed out by Nomiyama et al. (PMID: 20434943).
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Purified by affinity chromatography.
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXCL5 also known as LIX (Liposaccharide-induced CXC chemokine) is a small cytokine belonging to the CXC chemokine family. It plays a significant role in immunological responses by acting as a chemoattractant for neutrophils. CXCL5 has a molecular mass of around 12 kDa. The protein is mainly expressed in neutrophils epithelial cells and endothelial cells. It is often studied alongside its competitors in different therapeutic and diagnostic contexts.
Biological function summary

CXCL5 affects inflammation and the immune response by modulating neutrophil recruitment to sites of infection or injury. It is a part of the larger network of chemokines that direct leukocyte movement throughout the body. While CXCL5 does not form a complex in a traditional sense it does interact dynamically with CXCR2 receptor to exert its effects. These interactions are pivotal to the protein’s role in orchestrating the immune system’s response to diverse stimuli.

Pathways

CXCL5 plays a part in the chemokine signaling pathway and the inflammatory response pathway. These pathways are important in mediating immune surveillance and inflammation. CXCL5 through these pathways has a strong connection to other CXC family proteins like CXCL1 and the receptor CXCR2 which allows for a coordinated response during immune challenges and recovery processes.

CXCL5 is relevant in the context of chronic inflammatory disorders such as rheumatoid arthritis and cancer specifically its role in tumor-related inflammation. In these conditions CXCL5 is linked to the exacerbation of inflammatory states and promotion of tumor growth via angiogenesis. The protein's interactions with CXCR2 play a significant role in these disease processes representing potential therapeutic targets for managing inflammation and modulating cancer progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May participate in the recruitment of inflammatory cells by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-2(9-78) attract neutrophils and are involved in neutrophil activation.
See full target information Cxcl5
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell death and differentiation 32:1200-1213 PubMed40050422

2025

Cancer-intrinsic Cxcl5 orchestrates a global metabolic reprogramming for resistance to oxidative cell death in 3D.

Applications

Unspecified application

Species

Unspecified reactive species

Ramin Seo,Arvie Camille V de Guzman,Sunghyouk Park,Ji Youn Lee,Suk-Jo Kang

Cell discovery 10:109 PubMed39468013

2024

Targeting a chemo-induced adaptive signaling circuit confers therapeutic vulnerabilities in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yohei Saito,Yi Xiao,Jun Yao,Yunhai Li,Wendao Liu,Arseniy E Yuzhalin,Yueh-Ming Shyu,Hongzhong Li,Xiangliang Yuan,Ping Li,Qingling Zhang,Ziyi Li,Yongkun Wei,Xuedong Yin,Jun Zhao,Seyed M Kariminia,Yao-Chung Wu,Jinyang Wang,Jun Yang,Weiya Xia,Yutong Sun,Eek-Hoon Jho,Paul J Chiao,Rosa F Hwang,Haoqiang Ying,Huamin Wang,Zhongming Zhao,Anirban Maitra,Mien-Chie Hung,Ronald A DePinho,Dihua Yu

International journal of cancer 133:2872-83 PubMed23737434

2013

Deficiency of Kruppel-like factor KLF4 in mammary tumor cells inhibits tumor growth and pulmonary metastasis and is accompanied by compromised recruitment of myeloid-derived suppressor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Yu,Ying Shi,Junfeng Wang,Juan Li,Daping Fan,Walden Ai
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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