AB231102

Anti-CXCL7/PBP antibody

Name: Anti-CXCL7/PBP antibody (ab231102) | Abcam
Brand: Abcam Limited
SKU: AB231102

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(2 Publications)

Rabbit Polyclonal CXCL7/PBP antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 2 publications.

7 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL7/PBP antibody (AB231102)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL7/PBP antibody (AB231102)

Formalin-fixed, paraffin-embedded mouse lung tissue stained for CXCL7/PBP using ab231102 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL7/PBP antibody (AB231102)

Formalin-fixed, paraffin-embedded mouse spleen tissue stained for CXCL7/PBP using ab231102 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL7/PBP antibody (AB231102)

Formalin-fixed, paraffin-embedded mouse testis tissue stained for CXCL7/PBP using ab231102 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-CXCL7/PBP antibody (AB231102)

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Western blot - Anti-CXCL7/PBP antibody (ab231102) at 2 µg/mL

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Mouse spleen lysate

Predicted band size: 14 kDa

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Supplier Data

Western blot - Anti-CXCL7/PBP antibody (AB231102)

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Western blot - Anti-CXCL7/PBP antibody (ab231102) at 2 µg/mL

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Recombinant mouse CXCL7/PBP protein

Predicted band size: 14 kDa

false

Supplier Data

Western blot - Anti-CXCL7/PBP antibody (AB231102)

All lanes:

Western blot - Anti-CXCL7/PBP antibody (ab231102) at 2 µg/mL

All lanes:

Mouse lung lysate

Predicted band size: 14 kDa

false

Supplier Data

Western blot - Anti-CXCL7/PBP antibody (AB231102)

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Western blot - Anti-CXCL7/PBP antibody (ab231102) at 3 µg/mL

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Mouse serum

Predicted band size: 14 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

IHC-P, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

ab231102 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target CXCL7 also known as PBP PBP-172 or PPBP is a chemokine with a molecular mass of around 11 kDa. It is a platelet basic protein (PBP) belonging to the family of CXC chemokines. This protein is extensively expressed in megakaryocytes and stored in the alpha-granules of platelets. Upon platelet activation CXCL7 is released and becomes a potent attractant and activator of neutrophils. It travels through the bloodstream and impacts extracellular signaling processes.

Biological function summary

The chemokine plays a significant role in the regulation of inflammation. CXCL7 is not only an individual entity but can form complexes with glycosaminoglycans on cell surfaces enhancing its functionality. This interaction helps in modulating immune responses by recruiting neutrophils and monocytes to sites of injury or infection. The chemokine contributes to wound healing and tissue repair through its involvement in the inflammatory phase.

Pathways

CXCL7 is involved in the chemokine signaling pathway and is an important mediator in the immune system's response to infections. It is related to other chemokine family proteins like CXCL8 (IL-8) which share similar pathways in inflammatory responses. These proteins interact with specific receptors on leukocytes inducing changes in the cytoskeleton and promoting chemotaxis which is the directed movement towards chemical stimuli.

CXCL7 is associated with various inflammatory conditions and has been implicated in atherosclerosis and rheumatoid arthritis. In these conditions elevated levels of this chemokine correlate with increased recruitment and activation of neutrophils exacerbating inflammation. CXCL7 also shares interactions with other proteins such as CXCL1 affecting the progression and severity of these disorders. The understanding of CXCL7's role in such pathologies offers potential therapeutic avenues for intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

See full target information CXCL7/PBP

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:3517 PubMed38347040

2024

Aqueous humor TGFβ and fibrillin-1 in Tsk mice reveal clues to POAG pathogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

James C Tan,MinHee K Ko,Jeong-Im Woo,Kenneth L Lu,Jonathan A Kelber

Cancer research : PubMed33526510

2021

Host-derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma-induced Osteolysis and Reduces Overall Survival.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Hao Lo,Gemma Shay,Jeremy McGuire,Tao Li,Kenneth Shain,Jun Yong Choi,Rita Fuerst,William R Roush,Anna M Knapinska,Gregg B Fields,Conor C Lynch

View all publications

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