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AB202961

Anti-CXCL9 antibody

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(12 Publications)

Rabbit Polyclonal CXCL9 antibody. Suitable for IHC-P and reacts with Mouse, Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human CXCL9 aa 1-100 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

CMK, MIG, SCYB9, CXCL9, C-X-C motif chemokine 9, Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, Small-inducible cytokine B9, HuMIG

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL9 antibody (AB202961)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL9 antibody (AB202961)

Immunohistochemical analysis of formalin-fixed and paraffin embedded Human spleen tissue labeling CXCL9 using ab202961 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL9 antibody (AB202961)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCL9 antibody (AB202961)

Immunohistochemical analysis of formalin-fixed and paraffin embedded Mouse brain tissue labeling CXCL9 using ab202961 at 1/100 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human CXCL9 aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q07325

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>Use at 1/50 - 1/200 with fluorescent detection methods.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>Use at 1/50 - 1/200 with fluorescent detection methods.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXCL9 also known as MIG (monokine induced by gamma interferon) is a small cytokine protein with a molecular weight of approximately 13 kDa. CXCL9 exhibits strong chemotactic properties and is secreted by various cells including endothelial cells macrophages and fibroblasts upon stimulation by interferon-gamma. Its expression primarily occurs in inflamed tissues and is associated with immune responses. Researchers often use tools like a CXCL9 ELISA kit or CXCL9 test to measure its expression levels in biological samples aiding in understanding its role in various conditions.
Biological function summary

This cytokine plays a pivotal role in the immune system by regulating leukocyte trafficking. CXCL9 exerts its function through binding to the CXCR3 receptor attracting T cells towards sites of inflammation or infection. This interaction is significant in mediating immune surveillance and host defense. CXCL9 does not form part of a larger protein complex but its chemokine activity is critical for immune system coordination. Scientific studies often highlight its involvement through CXCL9 function and expression analysis.

Pathways

CXCL9 significantly influences the chemokine signaling pathway and the Th1-type adaptive immune response. Within these pathways it interacts closely with other chemokines like CXCL10 and CXCL11 which also bind to the CXCR3 receptor. These pathways highlight the coordinated mobilization of T cells during immune challenges and inflammation emphasizing how CXCL9 is often examined alongside these related chemokines in research settings.

CXCL9 is notably associated with autoimmune diseases such as rheumatoid arthritis and inflammatory conditions like psoriasis. Its elevated expression is often observed in affected tissues contributing to disease pathogenesis through T cell migration and activation. In these contexts CXCL9 is frequently examined alongside other pro-inflammatory cytokines such as interferon-gamma and TNF-alpha which are known to modulate its expression and activity impacting disease progression and therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
See full target information CXCL9
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Publications (12)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 10:479 PubMed39578426

2024

Systemic tumor regression with synergy therapy: radiotherapy and CAR-T.

Applications

Unspecified application

Species

Unspecified reactive species

Xingyu Ma,Wei Zhang,Miao Zeng,Teeranut Asavasupreechar,Synat Kang,Yisheng Li,Li Yu

BMC gastroenterology 24:417 PubMed39567902

2024

Correlation between PDGF-BB and M1-type macrophage in inflammatory bowel disease: a case-control study.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiyun Fang,Siwen Qu,Xia Ji,Chuwei Zheng,Juanfen Mo,Jianqiu Xu,Jinming Zhang,Haiyan Shen

Cell reports. Medicine 5:101648 PubMed38986624

2024

Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancers.

Applications

Unspecified application

Species

Unspecified reactive species

Lihuan Shang,Xue Jiang,Xinbao Zhao,Xi Huang,Xiaojuan Wang,Xue Jiang,Xiangzhan Kong,Mingkang Yao,Shanping Jiang,Ping-Pui Wong

Cancer research 83:4030-4046 PubMed37768887

2023

FGFR3 Alterations in Bladder Cancer Stimulate Serine Synthesis to Induce Immune-Inert Macrophages That Suppress T-cell Recruitment and Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Ouyang,Ziwei Ou,Wenlong Zhong,Jin Yang,Sha Fu,Nengtai Ouyang,Junyu Chen,Longhao Xu,Daqin Wu,Junan Qian,Yi Lin,Tianxin Lin,Jian Huang

Science advances 9:eade1282 PubMed37075107

2023

Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.

Applications

Unspecified application

Species

Unspecified reactive species

Avital Licht-Murava,Samantha M Meadows,Fernando Palaguachi,Soomin C Song,Stephanie Jackvony,Yaron Bram,Constance Zhou,Robert E Schwartz,Robert C Froemke,Adam L Orr,Anna G Orr

Nutrients 15: PubMed36839245

2023

Iodide Excess Inhibits Thyroid Hormone Synthesis Pathway Involving XBP1-Mediated Regulation.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Yu,Siyi Shen,Ying Yan,Lingxiao Liu,Rongkui Luo,Shengnan Liu,Yuting Wu,Yuying Li,Jingjing Jiang,Hao Ying

Pharmaceutical biology 61:281-287 PubMed36655287

2023

Mechanisms of action of polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9/CXCL10 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Liqian Peng,Yue Lu,Yingming Gu,Bihua Liang,Yanhong Li,Huaping Li,Yanan Ke,Huilan Zhu,Zhenjie Li

Nature communications 13:3155 PubMed35672321

2022

Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx.

Applications

Unspecified application

Species

Unspecified reactive species

Tae Gun Kang,Kee Woong Kwon,Kyungsoo Kim,Insuk Lee,Myeong Joon Kim,Sang-Jun Ha,Sung Jae Shin

Diabetologia 65:1185-1197 PubMed35511238

2022

Human adipose-derived mesenchymal stem cells prevent type 1 diabetes induced by immune checkpoint blockade.

Applications

Unspecified application

Species

Unspecified reactive species

Emi Kawada-Horitani,Shunbun Kita,Tomonori Okita,Yuto Nakamura,Hiroyuki Nishida,Yoichi Honma,Shiro Fukuda,Yuri Tsugawa-Shimizu,Junji Kozawa,Takaaki Sakaue,Yusuke Kawachi,Yuya Fujishima,Hitoshi Nishizawa,Miyuki Azuma,Norikazu Maeda,Iichiro Shimomura

Aging 13:2101-2117 PubMed33323542

2020

miR-588 is a prognostic marker in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yongyi Chen,Jie Zhang,Wangang Gong,Wumin Dai,Xiaohong Xu,Songxiao Xu
View all publications
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Product promise

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