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AB9720

Anti-CXCL9 antibody

4

(2 Reviews)

|

(12 Publications)

Rabbit Polyclonal CXCL9 antibody. Suitable for ELISA, WB, sELISA, IHC-P and reacts with Recombinant full length protein - Human, Human samples. Cited in 12 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CXCL9.

View Alternative Names

CMK, MIG, SCYB9, CXCL9, C-X-C motif chemokine 9, Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, Small-inducible cytokine B9, HuMIG

1 Images
Sandwich ELISA - Anti-CXCL9 antibody (AB9720)
  • sELISA

Unknown

Sandwich ELISA - Anti-CXCL9 antibody (AB9720)

Detection of hMIG (human Monokine induced by Interferon-Gamma) by sandwich ELISA (100 μl/well antibody solution). ab9720 as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hMIG.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Light chain type

unknown

Carrier free

No

Reacts with

Human

Applications

IHC-P, ELISA, WB, sELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CXCL9.

Q07325

Reactivity data

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Product details

Although some customers have been successful in IHC we no longer batch test in this application.

Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute with 200µl of sterile water.
Purification technique
Affinity purification Immunogen
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXCL9 also known as MIG (monokine induced by gamma interferon) is a small cytokine protein with a molecular weight of approximately 13 kDa. CXCL9 exhibits strong chemotactic properties and is secreted by various cells including endothelial cells macrophages and fibroblasts upon stimulation by interferon-gamma. Its expression primarily occurs in inflamed tissues and is associated with immune responses. Researchers often use tools like a CXCL9 ELISA kit or CXCL9 test to measure its expression levels in biological samples aiding in understanding its role in various conditions.
Biological function summary

This cytokine plays a pivotal role in the immune system by regulating leukocyte trafficking. CXCL9 exerts its function through binding to the CXCR3 receptor attracting T cells towards sites of inflammation or infection. This interaction is significant in mediating immune surveillance and host defense. CXCL9 does not form part of a larger protein complex but its chemokine activity is critical for immune system coordination. Scientific studies often highlight its involvement through CXCL9 function and expression analysis.

Pathways

CXCL9 significantly influences the chemokine signaling pathway and the Th1-type adaptive immune response. Within these pathways it interacts closely with other chemokines like CXCL10 and CXCL11 which also bind to the CXCR3 receptor. These pathways highlight the coordinated mobilization of T cells during immune challenges and inflammation emphasizing how CXCL9 is often examined alongside these related chemokines in research settings.

CXCL9 is notably associated with autoimmune diseases such as rheumatoid arthritis and inflammatory conditions like psoriasis. Its elevated expression is often observed in affected tissues contributing to disease pathogenesis through T cell migration and activation. In these contexts CXCL9 is frequently examined alongside other pro-inflammatory cytokines such as interferon-gamma and TNF-alpha which are known to modulate its expression and activity impacting disease progression and therapeutic strategies.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
See full target information CXCL9

Publications (12)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 9: PubMed39190494

2024

CXCL9, CXCL10, and CCL19 synergistically recruit T lymphocytes to skin in lichen planus.

Applications

Unspecified application

Species

Unspecified reactive species

Anna E Kersh,Satish Sati,Jianhe Huang,Christina Murphy,Olivia Ahart,Thomas H Leung

Experimental & molecular medicine 55:1713-1719 PubMed37524866

2023

Establishment of a humanized mouse model of keloid diseases following the migration of patient immune cells to the lesion: Patient-derived keloid xenograft (PDKX) model.

Applications

Unspecified application

Species

Unspecified reactive species

A Ram Lee,Seon-Yeong Lee,Jeong Won Choi,In Gyu Um,Hyun Sik Na,Jung Ho Lee,Mi-La Cho

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:2002497 PubMed33643790

2021

Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Won Choi,Young Hwa Kim,Seung Yeop Oh,Kwang Wook Suh,Young-Sam Kim,Ga-Yeon Lee,Jung Eun Yoon,Soon Sang Park,Young-Kyoung Lee,Yoo Jung Park,Hong Seok Kim,So Hyun Park,Jang-Hee Kim,Tae Jun Park

Molecular immunology 128:287-297 PubMed33248399

2020

Identification of key genes involved in JAK/STAT pathway in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyi Yue,Qiang Zhang,Si Wu,Shuang Wang,Changwan Cui,Miao Yu,Zhengrong Sun

Cancer science 111:4041-4050 PubMed32860283

2020

A ceRNA network and a potential regulatory axis in gastric cancer with different degrees of immune cell infiltration.

Applications

Unspecified application

Species

Unspecified reactive species

Kai Zhang,Lei Zhang,Yang Mi,YouCai Tang,FeiFei Ren,Bin Liu,Yi Zhang,PengYuan Zheng

Frontiers in physiology 11:441 PubMed32528301

2020

Exosomal MicroRNA-320a Derived From Mesenchymal Stem Cells Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Activation by Suppressing CXCL9 Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Meng,Bing Qiu

Aging 12:5048-5070 PubMed32181755

2020

Using ESTIMATE algorithm to establish an 8-mRNA signature prognosis prediction system and identify immunocyte infiltration-related genes in Pancreatic adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zibo Meng,Dianyun Ren,Kun Zhang,Jingyuan Zhao,Xin Jin,Heshui Wu

Cancer cell 35:885-900.e10 PubMed31185212

2019

Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Denarda Dangaj,Marine Bruand,Alizée J Grimm,Catherine Ronet,David Barras,Priyanka A Duttagupta,Evripidis Lanitis,Jaikumar Duraiswamy,Janos L Tanyi,Fabian Benencia,Jose Conejo-Garcia,Hena R Ramay,Kathleen T Montone,Daniel J Powell,Phyllis A Gimotty,Andrea Facciabene,Donald G Jackson,Jeffrey S Weber,Scott J Rodig,Stephen F Hodi,Lana E Kandalaft,Melita Irving,Lin Zhang,Periklis Foukas,Sylvie Rusakiewicz,Mauro Delorenzi,George Coukos

Molecular carcinogenesis 58:171-184 PubMed30302818

2018

Disparate roles of CXCR3A and CXCR3B in regulating progressive properties of colorectal cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hai Li,Shikuo Rong,Chao Chen,Yayun Fan,Tuo Chen,Yong Wang,Dongmei Chen,Chun Yang,Jiali Yang

Oncotarget 7:13976-83 PubMed26910919

2016

Elevated expression of IFN-inducible CXCR3 ligands predicts poor prognosis in patients with non-metastatic clear-cell renal cell carcinoma.

Applications

IHC

Species

Unspecified reactive species

Weisi Liu,Yidong Liu,Qiang Fu,Lin Zhou,Yuan Chang,Le Xu,Weijuan Zhang,Jiejie Xu
View all publications

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