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AB124344

Anti-CXCR1 antibody

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(7 Publications)

Rabbit Polyclonal CXCR1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human CXCR1.

View Alternative Names

CD181, CMKAR1, IL8RA, CXCR1, C-X-C chemokine receptor type 1, CXC-R1, CXCR-1, CDw128a, High affinity interleukin-8 receptor A, IL-8 receptor type 1, IL-8R A

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCR1 antibody (AB124344)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCR1 antibody (AB124344)

ab124344, at 1/100 dilution, staining CXCR1 in formalin-fixed, paraffin-embedded Human fetal tonsil tissue.

Western blot - Anti-CXCR1 antibody (AB124344)
  • WB

Unknown

Western blot - Anti-CXCR1 antibody (AB124344)

All lanes:

Western blot - Anti-CXCR1 antibody (ab124344) at 1/500 dilution

All lanes:

Human fetal skin lysate.

Predicted band size: 40 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human CXCR1. The exact immunogen used to generate this antibody is proprietary information.

P25024

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in 200 µL of water
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXCR1 also known as IL-8 receptor A is a G-protein-coupled receptor with a mass of approximately 40 kDa. It is primarily located on the surface of neutrophils a type of white blood cell and various other immune cells. CXCR1 recognizes and binds interleukin-8 (IL-8) an important chemokine that guides immune cells to sites of inflammation or infection. The binding of IL-8 to CXCR1 induces conformational changes activating intracellular signaling pathways which result in cellular responses like chemotaxis and phagocytosis.
Biological function summary

CXCR1 plays an important role in the immune system's response to infection and inflammation. It binds to IL-8 as part of the body's inflammatory response recruiting neutrophils and other immune cells to infected or damaged tissues. This receptor is not known to be part of a larger protein complex but it interacts with various signaling molecules within the cell to modulate cellular responses. The proper functioning of CXCR1 is essential for a balanced immune response and effective pathogen clearance.

Pathways

CXCR1 is an important component of the chemokine signaling pathway which is essential for the migration of immune cells to sites of inflammation. It also plays a critical role in the NF-kB signaling pathway which is involved in immune response and inflammation. Through these pathways CXCR1 interacts with other proteins like CXCR2 and IL-8 helping coordinate the movement and activation of immune cells necessary for defending against pathogens.

CXCR1 is linked to inflammatory diseases such as chronic obstructive pulmonary disease (COPD) and rheumatoid arthritis. It is involved in the excessive recruitment and activation of neutrophils contributing to tissue damage and disease progression. CXCR1 is also connected to CXCR2 in the context of these diseases as both receptors bind IL-8 and mediate similar inflammatory responses. Understanding CXCR1's role in these conditions can provide insights into developing targeted therapies aimed at reducing inflammation and disease severity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor (PubMed : 1840701). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed : 8662698).
See full target information CXCR1
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Signal transduction and targeted therapy 9:342 PubMed39638994

2024

CXCR1 neutrophil infiltration orchestrates response to third-generation EGFR-TKI in EGFR mutant non-small-cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Haowei Wang,Anwen Xiong,Xiaoxia Chen,Junhong Guo,Zhuoran Tang,Chunyan Wu,Shengxiang Ren,Caicun Zhou,Jian Chen,Likun Hou,Tao Jiang

Journal of extracellular vesicles 13:e12427 PubMed38545803

2024

The small extracellular vesicle-mediated intercellular transformation of CXCR1 to CXCR1 tumour cells promotes the progression of head and neck squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qiaoshi Xu,Aoming Cheng,Bo Li,Xutengyue Tian,Zhengxue Han,Zhien Feng

Bioengineered 12:6083-6095 PubMed34516330

2021

Long non-coding RNA PCED1B antisense RNA 1 promotes gastric cancer progression via modulating microRNA-215-3p / C-X-C motif chemokine receptor 1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Junyu Ren,Ning Xu,Ruize Zhou,Fengchang Huang,Hongbin Zhang,Wenliang Li

Journal of cellular and molecular medicine 25:6511-6523 PubMed34120407

2021

MiR-144-induced KLF2 inhibition and NF-kappaB/CXCR1 activation promote neutrophil extracellular trap-induced transfusion-related acute lung injury.

Applications

Unspecified application

Species

Unspecified reactive species

Aiping Le,Yize Wu,Wei Liu,Chenggao Wu,Piaoping Hu,Juan Zou,Linju Kuang

Histology and histopathology 35:83-96 PubMed31250425

2019

The evaluation of the distribution of CD133, CXCR1 and the tumor associated macrophages in different molecular subtypes of breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Can Ilgın,Erdem Çomut,Çağlar Sarıgül,Selçuk Korkmaz,Enver Vardar,Sevda Fatma Müftüoğlu

International journal of clinical and experimental 11:5327-5334 PubMed31949613

2018

miR-761 inhibits human osteosarcoma progression by targeting CXCR1.

Applications

Unspecified application

Species

Unspecified reactive species

Shaoyun Wang,Jinyu Zhang,Guoping Chen,Suwei Dong

Cytokine 108:96-104 PubMed29587155

2018

CXCL8 hyper-signaling in the aortic abdominal aneurysm.

Applications

IHC-P

Species

Human

Vivianne B C Kokje,Gabor Gäbel,Ron L Dalman,Dave Koole,Bernd H Northoff,Lesca M Holdt,Jaap F Hamming,Jan H N Lindeman
View all publications
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